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B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort.
Nutrients 2017; 9(5)N

Abstract

Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009-2016) were included, with a median follow-up time of 4.2 years. Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of 8000 supplements was developed. Associations were characterized by multivariable Cox models, and 462 incident breast cancers were diagnosed. Dietary (HRQ4vs.Q1 = 0.74 (0.55, 0.99), P-trend = 0.05), supplemental (HRQ4vs.Q1 = 0.61 (0.38, 0.98), P-trend = 0.05), and total (HRQ4vs.Q1 = 0.67 (0.50, 0.91), P-trend = 0.01) pyridoxine intakes were inversely associated with breast cancer risk. Total thiamin intake was borderline inversely associated with breast cancer risk (HRper 1-unit increment = 0.78 (0.61, 1.00), P = 0.05). Statistically significant interactions between alcohol consumption and B-vitamin (thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, folate, and cobalamin) supplemental intake were observed, the latter being inversely associated with breast cancer risk in non-to-low alcohol drinkers but not in higher drinkers. This large prospective study, including quantitative assessment of supplemental intake, suggests a potential protective effect of pyridoxine and thiamin on breast cancer risk in middle-aged women.

Authors+Show Affiliations

Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. manon.egnell@agroparistech.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. p.fassier@eren.smbh.univ-paris13.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. p.fassier@eren.smbh.univ-paris13.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. l.lecuyer@eren.smbh.univ-paris13.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. l.lecuyer@eren.smbh.univ-paris13.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. laurent.zelek@avc.aphp.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. laurent.zelek@avc.aphp.fr. Oncology Department, Avicenne Hospital, 93017 Bobigny, France. laurent.zelek@avc.aphp.fr.French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. m-paule.vasson@udamail.fr. UFR Pharmacie, Inra, UMR 1019, CRNH Auvergne, Centre Jean-Perrin, CHU Gabriel-Montpied, Unité de Nutrition, Clermont Université, Université d'Auvergne, 63000 Clermont-Ferrand, France. m-paule.vasson@udamail.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. s.hercberg@eren.smbh.univ-paris13.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. s.hercberg@eren.smbh.univ-paris13.fr. Public Health Department, Avicenne Hospital, 93017 Bobigny, France. s.hercberg@eren.smbh.univ-paris13.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. paule.martel@jouy.inra.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. paule.martel@jouy.inra.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. p.galan@eren.smbh.univ-paris13.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. m.deschasaux@eren.smbh.univ-paris13.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. m.deschasaux@eren.smbh.univ-paris13.fr.Sorbonne Paris Cité Epidemiology and Statistics Research Center (CRESS), Inserm U1153, Inra U1125, Cnam, Paris 13 University, Nutritional Epidemiology Research Team (EREN), 74 rue Marcel Cachin, 93017 Bobigny, France. m.touvier@eren.smbh.univ-paris13.fr. French Network for Nutrition and Cancer Research (NACRe Network), 78352 Jouy-en-Josas, France. m.touvier@eren.smbh.univ-paris13.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28505069

Citation

Egnell, Manon, et al. "B-Vitamin Intake From Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results From the Prospective NutriNet-Santé Cohort." Nutrients, vol. 9, no. 5, 2017.
Egnell M, Fassier P, Lécuyer L, et al. B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort. Nutrients. 2017;9(5).
Egnell, M., Fassier, P., Lécuyer, L., Zelek, L., Vasson, M. P., Hercberg, S., ... Touvier, M. (2017). B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort. Nutrients, 9(5), doi:10.3390/nu9050488.
Egnell M, et al. B-Vitamin Intake From Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results From the Prospective NutriNet-Santé Cohort. Nutrients. 2017 May 13;9(5) PubMed PMID: 28505069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort. AU - Egnell,Manon, AU - Fassier,Philippine, AU - Lécuyer,Lucie, AU - Zelek,Laurent, AU - Vasson,Marie-Paule, AU - Hercberg,Serge, AU - Latino-Martel,Paule, AU - Galan,Pilar, AU - Deschasaux,Mélanie, AU - Touvier,Mathilde, Y1 - 2017/05/13/ PY - 2017/03/02/received PY - 2017/05/09/revised PY - 2017/05/10/accepted PY - 2017/5/16/entrez PY - 2017/5/16/pubmed PY - 2018/3/27/medline KW - B-vitamins KW - breast cancer risk KW - diet KW - dietary supplements KW - prospective cohort JF - Nutrients JO - Nutrients VL - 9 IS - 5 N2 - Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009-2016) were included, with a median follow-up time of 4.2 years. Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of 8000 supplements was developed. Associations were characterized by multivariable Cox models, and 462 incident breast cancers were diagnosed. Dietary (HRQ4vs.Q1 = 0.74 (0.55, 0.99), P-trend = 0.05), supplemental (HRQ4vs.Q1 = 0.61 (0.38, 0.98), P-trend = 0.05), and total (HRQ4vs.Q1 = 0.67 (0.50, 0.91), P-trend = 0.01) pyridoxine intakes were inversely associated with breast cancer risk. Total thiamin intake was borderline inversely associated with breast cancer risk (HRper 1-unit increment = 0.78 (0.61, 1.00), P = 0.05). Statistically significant interactions between alcohol consumption and B-vitamin (thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, folate, and cobalamin) supplemental intake were observed, the latter being inversely associated with breast cancer risk in non-to-low alcohol drinkers but not in higher drinkers. This large prospective study, including quantitative assessment of supplemental intake, suggests a potential protective effect of pyridoxine and thiamin on breast cancer risk in middle-aged women. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28505069/B_Vitamin_Intake_from_Diet_and_Supplements_and_Breast_Cancer_Risk_in_Middle_Aged_Women:_Results_from_the_Prospective_NutriNet_Santé_Cohort_ L2 - http://www.mdpi.com/resolver?pii=nu9050488 DB - PRIME DP - Unbound Medicine ER -