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Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience.
Am J Clin Pathol. 2017 Jun 01; 147(6):571-579.AJ

Abstract

Objectives

To assess the diagnostic performance of ultrasound-guided fine-needle aspiration (USFNA) in nonpalpable breast lesions (NPBLs) in a multidisciplinary setting.

Methods

In total, 2,601 NPBLs underwent USFNA by a radiologist-pathologist team. Gold-standard diagnosis was based on surgery, core-needle biopsy, or 1-year imaging follow-up. USFNA's diagnostic performance was analyzed in different clinical and imaging subgroups.

Results

USFNA's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were, respectively, 92.6% (95% confidence interval [CI], 90.8%-94.2%), 96.8% (95% CI, 95.8%-97.6%), 94.8% (95% CI, 93.2%-96.1%), and 95.4% (95% CI, 94.3%-96.4%). The best PPV was achieved in Breast-Imaging Reporting and Data System (BI-RADS) categories 4C and 5 and the best NPV in BI-RADS categories 2, 3, and 4A and in patients younger than 50 years. The mitotic count, BI-RADS categories, associated palpable cancer, and age (<50 or ≥50 years) were statistically independent factors (P < .05) between USFNA's false-negative and true-positive results.

Conclusions

USFNA is a robust diagnostic procedure in NPBLs. Age and the BI-RADS category of the lesion are important factors determining its performance.

Authors+Show Affiliations

From the Departments of Tumor Biology.Radiology.Radiology.Radiology.Surgical Oncology.Surgical Oncology.From the Departments of Tumor Biology.From the Departments of Tumor Biology.From the Departments of Tumor Biology.Public Health Department, Institut Curie, Paris, France.Surgical Oncology.From the Departments of Tumor Biology.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28505308

Citation

Farras Roca, Josep A., et al. "Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: the Institut Curie's Experience." American Journal of Clinical Pathology, vol. 147, no. 6, 2017, pp. 571-579.
Farras Roca JA, Tardivon A, Thibault F, et al. Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience. Am J Clin Pathol. 2017;147(6):571-579.
Farras Roca, J. A., Tardivon, A., Thibault, F., El Khoury, C., Alran, S., Fourchotte, V., Marck, V., Alépée, B., Sigal, B., de Rycke, Y., Rouzier, R., & Klijanienko, J. (2017). Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience. American Journal of Clinical Pathology, 147(6), 571-579. https://doi.org/10.1093/ajcp/aqx009
Farras Roca JA, et al. Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: the Institut Curie's Experience. Am J Clin Pathol. 2017 Jun 1;147(6):571-579. PubMed PMID: 28505308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic Performance of Ultrasound-Guided Fine-Needle Aspiration of Nonpalpable Breast Lesions in a Multidisciplinary Setting: The Institut Curie's Experience. AU - Farras Roca,Josep A, AU - Tardivon,Anne, AU - Thibault,Fabienne, AU - El Khoury,Carl, AU - Alran,Séverine, AU - Fourchotte,Virginie, AU - Marck,Véronique, AU - Alépée,Bernard, AU - Sigal,Birigitte, AU - de Rycke,Yann, AU - Rouzier,Roman, AU - Klijanienko,Jerzy, PY - 2017/5/16/pubmed PY - 2017/10/14/medline PY - 2017/5/16/entrez KW - Breast KW - Diagnostic performance KW - Fine-needle aspiration KW - Nonpalpable KW - Ultrasound guided SP - 571 EP - 579 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 147 IS - 6 N2 - Objectives: To assess the diagnostic performance of ultrasound-guided fine-needle aspiration (USFNA) in nonpalpable breast lesions (NPBLs) in a multidisciplinary setting. Methods: In total, 2,601 NPBLs underwent USFNA by a radiologist-pathologist team. Gold-standard diagnosis was based on surgery, core-needle biopsy, or 1-year imaging follow-up. USFNA's diagnostic performance was analyzed in different clinical and imaging subgroups. Results: USFNA's sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were, respectively, 92.6% (95% confidence interval [CI], 90.8%-94.2%), 96.8% (95% CI, 95.8%-97.6%), 94.8% (95% CI, 93.2%-96.1%), and 95.4% (95% CI, 94.3%-96.4%). The best PPV was achieved in Breast-Imaging Reporting and Data System (BI-RADS) categories 4C and 5 and the best NPV in BI-RADS categories 2, 3, and 4A and in patients younger than 50 years. The mitotic count, BI-RADS categories, associated palpable cancer, and age (<50 or ≥50 years) were statistically independent factors (P < .05) between USFNA's false-negative and true-positive results. Conclusions: USFNA is a robust diagnostic procedure in NPBLs. Age and the BI-RADS category of the lesion are important factors determining its performance. SN - 1943-7722 UR - https://www.unboundmedicine.com/medline/citation/28505308/Diagnostic_Performance_of_Ultrasound_Guided_Fine_Needle_Aspiration_of_Nonpalpable_Breast_Lesions_in_a_Multidisciplinary_Setting:_The_Institut_Curie's_Experience_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/aqx009 DB - PRIME DP - Unbound Medicine ER -