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Muscle wasting in chronic kidney disease.
Pediatr Nephrol. 2018 05; 33(5):789-798.PN

Abstract

Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases. However, data regarding cachexia/PEW and muscle wasting in children with CKD is scarce due to lack of consensus in diagnostic criteria and an appropriate investigative methodology. Further research is urgently needed to address this important complication in the pediatric CKD setting, which may have fundamental impact on clinical outcomes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Oliveira EA
Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, MC 0630, La Jolla, CA, 92093-0630, USA. Pediatric Nephrourology Division, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Cheung WW
Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, MC 0630, La Jolla, CA, 92093-0630, USA.
Toma KG
Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, MC 0630, La Jolla, CA, 92093-0630, USA.
Mak RH
Division of Pediatric Nephrology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, MC 0630, La Jolla, CA, 92093-0630, USA. romak@ucsd.edu.

MeSH

AdolescentCachexiaChildChild, PreschoolFemaleHumansMaleRenal Insufficiency, ChronicRisk FactorsYoung Adult

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

28508131

Citation

Oliveira, Eduardo A., et al. "Muscle Wasting in Chronic Kidney Disease." Pediatric Nephrology (Berlin, Germany), vol. 33, no. 5, 2018, pp. 789-798.
Oliveira EA, Cheung WW, Toma KG, et al. Muscle wasting in chronic kidney disease. Pediatr Nephrol. 2018;33(5):789-798.
Oliveira, E. A., Cheung, W. W., Toma, K. G., & Mak, R. H. (2018). Muscle wasting in chronic kidney disease. Pediatric Nephrology (Berlin, Germany), 33(5), 789-798. https://doi.org/10.1007/s00467-017-3684-6
Oliveira EA, et al. Muscle Wasting in Chronic Kidney Disease. Pediatr Nephrol. 2018;33(5):789-798. PubMed PMID: 28508131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Muscle wasting in chronic kidney disease. AU - Oliveira,Eduardo A, AU - Cheung,Wai W, AU - Toma,Kalodiah G, AU - Mak,Robert H, Y1 - 2017/05/15/ PY - 2017/01/30/received PY - 2017/04/18/accepted PY - 2017/04/17/revised PY - 2017/5/17/pubmed PY - 2019/6/14/medline PY - 2017/5/17/entrez KW - Cachexia KW - Children KW - Chronic kidney disease KW - Muscle wasting KW - Protein energy wasting SP - 789 EP - 798 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 33 IS - 5 N2 - Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death. Children with CKD have many risk factors for lean mass and muscle wasting, including poor appetite, inflammation, growth hormone resistance, and metabolic acidosis. Mortality risks in patients with CKD increases as body mass index (BMI) and weight decreases. However, data regarding cachexia/PEW and muscle wasting in children with CKD is scarce due to lack of consensus in diagnostic criteria and an appropriate investigative methodology. Further research is urgently needed to address this important complication in the pediatric CKD setting, which may have fundamental impact on clinical outcomes. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/28508131/Muscle_wasting_in_chronic_kidney_disease_ L2 - https://dx.doi.org/10.1007/s00467-017-3684-6 DB - PRIME DP - Unbound Medicine ER -