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Diagnosis and Management of Parkinson's Disease.
Semin Neurol. 2017 04; 37(2):118-126.SN

Abstract

Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of Parkinson's disease (PD) is still based on clinical criteria that include the presence of a combination of cardinal motor features (tremor, rigidity, bradykinesia, and postural instability), other motor features (including freezing of gait and abnormal postures), and numerous nonmotor features. In addition, the presence of atypical features may suggest an alternative diagnosis. Levodopa therapy remains the gold standard in the management of motor features of PD. New formulations of levodopa and novel delivery systems are currently being evaluated and gradually introduced in clinical practice in an attempt to prevent or treat levodopa-related motor complications. Dopamine agonists also play an important role as monotherapy in mild or adjunctive therapy in moderately advanced disease. As the disease progresses and patients develop complications from levodopa therapy, specifically motor fluctuations and dyskinesias, deep brain stimulation becomes an alternative therapeutic option. Clinical trials of experimental therapeutics are currently fueling the PD therapeutic pipeline.

Authors+Show Affiliations

Department of Neurology, Parkinson's Disease Center and Movement Disorder Clinic, Baylor College of Medicine, Houston, Texas.Department of Neurology, Parkinson's Disease Center and Movement Disorder Clinic, Baylor College of Medicine, Houston, Texas.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28511252

Citation

Tarakad, Arjun, and Joseph Jankovic. "Diagnosis and Management of Parkinson's Disease." Seminars in Neurology, vol. 37, no. 2, 2017, pp. 118-126.
Tarakad A, Jankovic J. Diagnosis and Management of Parkinson's Disease. Semin Neurol. 2017;37(2):118-126.
Tarakad, A., & Jankovic, J. (2017). Diagnosis and Management of Parkinson's Disease. Seminars in Neurology, 37(2), 118-126. https://doi.org/10.1055/s-0037-1601888
Tarakad A, Jankovic J. Diagnosis and Management of Parkinson's Disease. Semin Neurol. 2017;37(2):118-126. PubMed PMID: 28511252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis and Management of Parkinson's Disease. AU - Tarakad,Arjun, AU - Jankovic,Joseph, Y1 - 2017/05/16/ PY - 2017/5/17/entrez PY - 2017/5/17/pubmed PY - 2018/5/1/medline SP - 118 EP - 126 JF - Seminars in neurology JO - Semin Neurol VL - 37 IS - 2 N2 - Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of Parkinson's disease (PD) is still based on clinical criteria that include the presence of a combination of cardinal motor features (tremor, rigidity, bradykinesia, and postural instability), other motor features (including freezing of gait and abnormal postures), and numerous nonmotor features. In addition, the presence of atypical features may suggest an alternative diagnosis. Levodopa therapy remains the gold standard in the management of motor features of PD. New formulations of levodopa and novel delivery systems are currently being evaluated and gradually introduced in clinical practice in an attempt to prevent or treat levodopa-related motor complications. Dopamine agonists also play an important role as monotherapy in mild or adjunctive therapy in moderately advanced disease. As the disease progresses and patients develop complications from levodopa therapy, specifically motor fluctuations and dyskinesias, deep brain stimulation becomes an alternative therapeutic option. Clinical trials of experimental therapeutics are currently fueling the PD therapeutic pipeline. SN - 1098-9021 UR - https://www.unboundmedicine.com/medline/citation/28511252/Diagnosis_and_Management_of_Parkinson's_Disease_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0037-1601888 DB - PRIME DP - Unbound Medicine ER -