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Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels.
Nutr Metab Cardiovasc Dis. 2017 Jul; 27(7):601-608.NM

Abstract

BACKGROUND AND AIMS

A link between increased blood viscosity and type 2 diabetes has been previously reported. Herein, we investigated the association of blood viscosity with prediabetes, identified by glycated hemoglobin A1c (HbA1c) according to the new American Diabetes Association criteria, and subclinical atherosclerosis.

METHODS AND RESULTS

The study cohort includes 1136 non-diabetic adults submitted to anthropometrical evaluation, an oral glucose tolerance test and ultrasound measurement of carotid intima-media thickness (IMT). Whole blood viscosity was estimated using a validated formula based on hematocrit and total plasma proteins. After adjusting for age, and gender, individuals with HbA1c-defined prediabetes (HbA1c 5.7-6.4% [39-47 mmol/mol]) exhibited significantly higher values of hematocrit, and predicted blood viscosity as compared with controls. Increased levels of IMT were observed in subjects with HbA1c-defined prediabetes in comparison to controls. Predicted blood viscosity was positively correlated with age, waist circumference, blood pressure, cholesterol, triglycerides, fibrinogen, white blood cell, HbA1c, fasting and 2-h post-load glucose levels, fasting insulin, IMT and inversely correlated with HDL and Matsuda index of insulin sensitivity. Of the three glycemic parameters, i.e. HbA1c, fasting and 2-h post-load glucose, only HbA1c showed a significant correlation with predicted blood viscosity (β = 0.054, P = 0.04) in a multivariate regression analysis model including multiple atherosclerosis risk factors.

CONCLUSION

The study shows that individuals with HbA1c-defined prediabetes have increased predicted blood viscosity and IMT. The HbA1c criterion may be helpful to capture individuals with an increased risk of diabetes and cardiovascular disease who may benefit from an intensive lifestyle intervention.

Authors+Show Affiliations

Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.Department of Medical and Surgical Sciences, University Magna-Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy. Electronic address: sesti@unicz.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28511905

Citation

Marini, M A., et al. "Hemorheological Alterations in Adults With Prediabetes Identified By Hemoglobin A1c Levels." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 27, no. 7, 2017, pp. 601-608.
Marini MA, Fiorentino TV, Andreozzi F, et al. Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels. Nutr Metab Cardiovasc Dis. 2017;27(7):601-608.
Marini, M. A., Fiorentino, T. V., Andreozzi, F., Mannino, G. C., Succurro, E., Sciacqua, A., Perticone, F., & Sesti, G. (2017). Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 27(7), 601-608. https://doi.org/10.1016/j.numecd.2017.04.001
Marini MA, et al. Hemorheological Alterations in Adults With Prediabetes Identified By Hemoglobin A1c Levels. Nutr Metab Cardiovasc Dis. 2017;27(7):601-608. PubMed PMID: 28511905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemorheological alterations in adults with prediabetes identified by hemoglobin A1c levels. AU - Marini,M A, AU - Fiorentino,T V, AU - Andreozzi,F, AU - Mannino,G C, AU - Succurro,E, AU - Sciacqua,A, AU - Perticone,F, AU - Sesti,G, Y1 - 2017/04/21/ PY - 2017/01/24/received PY - 2017/04/11/revised PY - 2017/04/11/accepted PY - 2017/5/18/pubmed PY - 2017/9/12/medline PY - 2017/5/18/entrez KW - Blood viscosity KW - Cardiovascular risk KW - HbA1c KW - Hematocrit KW - Prediabetes SP - 601 EP - 608 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 27 IS - 7 N2 - BACKGROUND AND AIMS: A link between increased blood viscosity and type 2 diabetes has been previously reported. Herein, we investigated the association of blood viscosity with prediabetes, identified by glycated hemoglobin A1c (HbA1c) according to the new American Diabetes Association criteria, and subclinical atherosclerosis. METHODS AND RESULTS: The study cohort includes 1136 non-diabetic adults submitted to anthropometrical evaluation, an oral glucose tolerance test and ultrasound measurement of carotid intima-media thickness (IMT). Whole blood viscosity was estimated using a validated formula based on hematocrit and total plasma proteins. After adjusting for age, and gender, individuals with HbA1c-defined prediabetes (HbA1c 5.7-6.4% [39-47 mmol/mol]) exhibited significantly higher values of hematocrit, and predicted blood viscosity as compared with controls. Increased levels of IMT were observed in subjects with HbA1c-defined prediabetes in comparison to controls. Predicted blood viscosity was positively correlated with age, waist circumference, blood pressure, cholesterol, triglycerides, fibrinogen, white blood cell, HbA1c, fasting and 2-h post-load glucose levels, fasting insulin, IMT and inversely correlated with HDL and Matsuda index of insulin sensitivity. Of the three glycemic parameters, i.e. HbA1c, fasting and 2-h post-load glucose, only HbA1c showed a significant correlation with predicted blood viscosity (β = 0.054, P = 0.04) in a multivariate regression analysis model including multiple atherosclerosis risk factors. CONCLUSION: The study shows that individuals with HbA1c-defined prediabetes have increased predicted blood viscosity and IMT. The HbA1c criterion may be helpful to capture individuals with an increased risk of diabetes and cardiovascular disease who may benefit from an intensive lifestyle intervention. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/28511905/Hemorheological_alterations_in_adults_with_prediabetes_identified_by_hemoglobin_A1c_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(17)30064-9 DB - PRIME DP - Unbound Medicine ER -