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Adverse effects of consuming high fat-sugar diets on cognition: implications for understanding obesity.
Proc Nutr Soc 2017; 76(4):455-465PN

Abstract

There is increasing evidence for important roles of key cognitive processes, including attention, memory and learning, in the short-term decision making about eating. There is parallel evidence that people who are overweight or obese tend to perform worse on a variety of cognitive tasks. In this review, the evidence for these two ideas is summarised and then the idea that overconsumption of Western-style high-fat (HF)-high-sugar diets may underlie the association between obesity and poorer cognitive performance is explored. In particular, evidence in animals and human subjects that repeated consumption of HF or HF and sugar (HFS) diets leads to specific impairments in the functioning of the hippocampus, which underpin the consequent changes in cognition is summarised. These findings lead into the vicious cycle model (VCM), which suggests that these cognitive changes have knock-on negative effects for future appetite control, and evidence that altered hippocampal function is also associated with impaired appetite control is explored. The review concludes that there is consistent evidence in the animal literature and emerging evidence from human studies that supports this VCM. It is also noted, however, that to date studies lack the nutritional specificity needed to be able to translate these basic research findings into clear nutritional effects, and concludes that there is an urgent need for additional research to clarify the precise nature of the apparent effects of consuming HFS diets on cognition.

Authors+Show Affiliations

School of Psychology,University of Sussex,Brighton BN1 9QH,UK.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28514983

Citation

Yeomans, Martin R.. "Adverse Effects of Consuming High Fat-sugar Diets On Cognition: Implications for Understanding Obesity." The Proceedings of the Nutrition Society, vol. 76, no. 4, 2017, pp. 455-465.
Yeomans MR. Adverse effects of consuming high fat-sugar diets on cognition: implications for understanding obesity. Proc Nutr Soc. 2017;76(4):455-465.
Yeomans, M. R. (2017). Adverse effects of consuming high fat-sugar diets on cognition: implications for understanding obesity. The Proceedings of the Nutrition Society, 76(4), pp. 455-465. doi:10.1017/S0029665117000805.
Yeomans MR. Adverse Effects of Consuming High Fat-sugar Diets On Cognition: Implications for Understanding Obesity. Proc Nutr Soc. 2017;76(4):455-465. PubMed PMID: 28514983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse effects of consuming high fat-sugar diets on cognition: implications for understanding obesity. A1 - Yeomans,Martin R, Y1 - 2017/05/18/ PY - 2017/5/19/pubmed PY - 2018/7/6/medline PY - 2017/5/19/entrez KW - BDNF brain-derived neurotrophic factor KW - DFS Dietary Fat and Free Sugar Questionnaire KW - HF high-fat diet KW - HFS high fat and high sugar diet KW - SF saturated fat KW - VCM vicious cycle model KW - Cognition KW - Diet KW - Memory KW - Obesity SP - 455 EP - 465 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 76 IS - 4 N2 - There is increasing evidence for important roles of key cognitive processes, including attention, memory and learning, in the short-term decision making about eating. There is parallel evidence that people who are overweight or obese tend to perform worse on a variety of cognitive tasks. In this review, the evidence for these two ideas is summarised and then the idea that overconsumption of Western-style high-fat (HF)-high-sugar diets may underlie the association between obesity and poorer cognitive performance is explored. In particular, evidence in animals and human subjects that repeated consumption of HF or HF and sugar (HFS) diets leads to specific impairments in the functioning of the hippocampus, which underpin the consequent changes in cognition is summarised. These findings lead into the vicious cycle model (VCM), which suggests that these cognitive changes have knock-on negative effects for future appetite control, and evidence that altered hippocampal function is also associated with impaired appetite control is explored. The review concludes that there is consistent evidence in the animal literature and emerging evidence from human studies that supports this VCM. It is also noted, however, that to date studies lack the nutritional specificity needed to be able to translate these basic research findings into clear nutritional effects, and concludes that there is an urgent need for additional research to clarify the precise nature of the apparent effects of consuming HFS diets on cognition. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/28514983/Adverse_effects_of_consuming_high_fat_sugar_diets_on_cognition:_implications_for_understanding_obesity_ L2 - https://www.cambridge.org/core/product/identifier/S0029665117000805/type/journal_article DB - PRIME DP - Unbound Medicine ER -