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The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
J Allergy Clin Immunol. 2017 Jul; 140(1):145-153.e8.JA

Abstract

BACKGROUND

The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse.

OBJECTIVE

This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years.

METHODS

HealthNuts is a population-based cohort study with baseline recruitment of 5276 one-year-old children who underwent skin prick test (SPT) to 4 food allergens and those with detectable SPT results had formal food challenges. At age 4 years, parents completed a questionnaire (81.3% completed) and those who previously attended the HealthNuts clinic at age 1 year or reported symptoms of a new food allergy were invited for an assessment that included SPT and oral food challenges. Data on asthma, eczema, and allergic rhinitis were captured by validated International Study of Asthma and Allergies in Childhood questionnaires.

RESULTS

The prevalence of challenge-confirmed food allergy at age 1 and 4 years was 11.0% and 3.8%, respectively. At age 4 years, peanut allergy prevalence was 1.9% (95% CI, 1.6% to 2.3%), egg allergy was 1.2% (95% CI, 0.9% to 1.6%), and sesame allergy was 0.4% (95% CI, 0.3% to 0.6%). Late-onset peanut allergy at age 4 years was rare (0.2%). The prevalence of current asthma was 10.8% (95% CI, 9.7% to 12.1%), current eczema was 16.0% (95% CI, 14.7% to 17.4%), and current allergic rhinitis was 8.3% (95% CI, 7.2% to 9.4%). Forty percent to 50% of this population-based cohort experienced symptoms of an allergic disease in the first 4 years of their life.

CONCLUSIONS

Although the prevalence of food allergy decreased between age 1 year and age 4 years in this population-based cohort, the prevalence of any allergic disease among 4-year-old children in Melbourne, Australia, is remarkably high.

Authors+Show Affiliations

Murdoch Childrens Research Institute, Parkville, Australia.Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Carlton, Australia.School of Population and Global Health, University of Melbourne, Carlton, Australia.School of Population and Global Health, University of Melbourne, Carlton, Australia.Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Paediatrics and the Liggins Institute, The University of Auckland, Auckland, New Zealand.Murdoch Childrens Research Institute, Parkville, Australia; School of Population and Global Health, University of Melbourne, Carlton, Australia.Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia.School of Population and Global Health, University of Melbourne, Carlton, Australia.School of Population and Global Health, University of Melbourne, Carlton, Australia.Murdoch Childrens Research Institute, Parkville, Australia; George Institute for Global Health, University of Oxford, Oxford, United Kingdom.Murdoch Childrens Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Allergy and Immunology, Royal Children's Hospital, Parkville, Australia; Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom. Electronic address: katie.allen@rch.org.au.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28514997

Citation

Peters, Rachel L., et al. "The Prevalence of Food Allergy and Other Allergic Diseases in Early Childhood in a Population-based Study: HealthNuts Age 4-year Follow-up." The Journal of Allergy and Clinical Immunology, vol. 140, no. 1, 2017, pp. 145-153.e8.
Peters RL, Koplin JJ, Gurrin LC, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. J Allergy Clin Immunol. 2017;140(1):145-153.e8.
Peters, R. L., Koplin, J. J., Gurrin, L. C., Dharmage, S. C., Wake, M., Ponsonby, A. L., Tang, M. L. K., Lowe, A. J., Matheson, M., Dwyer, T., & Allen, K. J. (2017). The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. The Journal of Allergy and Clinical Immunology, 140(1), 145-e8. https://doi.org/10.1016/j.jaci.2017.02.019
Peters RL, et al. The Prevalence of Food Allergy and Other Allergic Diseases in Early Childhood in a Population-based Study: HealthNuts Age 4-year Follow-up. J Allergy Clin Immunol. 2017;140(1):145-153.e8. PubMed PMID: 28514997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. AU - Peters,Rachel L, AU - Koplin,Jennifer J, AU - Gurrin,Lyle C, AU - Dharmage,Shyamali C, AU - Wake,Melissa, AU - Ponsonby,Anne-Louise, AU - Tang,Mimi L K, AU - Lowe,Adrian J, AU - Matheson,Melanie, AU - Dwyer,Terence, AU - Allen,Katrina J, AU - ,, Y1 - 2017/05/14/ PY - 2016/09/26/received PY - 2017/01/31/revised PY - 2017/02/03/accepted PY - 2017/5/19/pubmed PY - 2017/8/30/medline PY - 2017/5/19/entrez KW - Allergy KW - HealthNuts KW - allergic rhinitis KW - asthma KW - eczema KW - egg allergy KW - food allergy KW - longitudinal study KW - peanut allergy KW - population-based study KW - prevalence KW - sesame allergy SP - 145 EP - 153.e8 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 140 IS - 1 N2 - BACKGROUND: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. OBJECTIVE: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years. METHODS: HealthNuts is a population-based cohort study with baseline recruitment of 5276 one-year-old children who underwent skin prick test (SPT) to 4 food allergens and those with detectable SPT results had formal food challenges. At age 4 years, parents completed a questionnaire (81.3% completed) and those who previously attended the HealthNuts clinic at age 1 year or reported symptoms of a new food allergy were invited for an assessment that included SPT and oral food challenges. Data on asthma, eczema, and allergic rhinitis were captured by validated International Study of Asthma and Allergies in Childhood questionnaires. RESULTS: The prevalence of challenge-confirmed food allergy at age 1 and 4 years was 11.0% and 3.8%, respectively. At age 4 years, peanut allergy prevalence was 1.9% (95% CI, 1.6% to 2.3%), egg allergy was 1.2% (95% CI, 0.9% to 1.6%), and sesame allergy was 0.4% (95% CI, 0.3% to 0.6%). Late-onset peanut allergy at age 4 years was rare (0.2%). The prevalence of current asthma was 10.8% (95% CI, 9.7% to 12.1%), current eczema was 16.0% (95% CI, 14.7% to 17.4%), and current allergic rhinitis was 8.3% (95% CI, 7.2% to 9.4%). Forty percent to 50% of this population-based cohort experienced symptoms of an allergic disease in the first 4 years of their life. CONCLUSIONS: Although the prevalence of food allergy decreased between age 1 year and age 4 years in this population-based cohort, the prevalence of any allergic disease among 4-year-old children in Melbourne, Australia, is remarkably high. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/28514997/The_prevalence_of_food_allergy_and_other_allergic_diseases_in_early_childhood_in_a_population_based_study:_HealthNuts_age_4_year_follow_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(17)30412-8 DB - PRIME DP - Unbound Medicine ER -