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Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake.

Abstract

To evaluate the association between alcohol consumption and breast cancer risk in younger women, overall and by family history of breast cancer and folate intake, we prospectively followed 93,835 US women aged 27-44 years in Nurses' Health Study II who had alcohol consumption data in 1991. Alcohol consumption and folate intake were measured by food frequency questionnaire every 4 years. We documented 2,866 incident cases of invasive breast cancer between 1991 and 2011. Alcohol consumption was not associated with breast cancer risk overall (for intake of ≥10 g/day vs. nondrinking, multivariate hazard ratio = 1.07, 95% confidence interval: 0.94, 1.22). When the association was stratified by family history and folate intake, a positive association between alcohol consumption and breast cancer was found among women with a family history and folate intake less than 400 μg/day (multivariate hazard ratio = 1.82, 95% confidence interval: 1.06, 3.12; P-trend = 0.08). Alcohol consumption was not associated with breast cancer in other categories of family history and folate intake (P-interaction = 0.55). In conclusion, in this population of younger women, higher alcohol consumption was associated with increased risk of breast cancer among those with both a family history of breast cancer and lower folate intake.

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  • Authors

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    Source

    American journal of epidemiology 186:5 2017 Sep 01 pg 524-531

    MeSH

    Adult
    Age Distribution
    Alcohol Drinking
    Body Mass Index
    Breast Neoplasms
    Contraceptives, Oral
    Diet Records
    Female
    Folic Acid
    Humans
    Incidence
    Medical History Taking
    Menarche
    Parity
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28520842

    Citation

    Kim, Hyun Ja, et al. "Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake." American Journal of Epidemiology, vol. 186, no. 5, 2017, pp. 524-531.
    Kim HJ, Jung S, Eliassen AH, et al. Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake. Am J Epidemiol. 2017;186(5):524-531.
    Kim, H. J., Jung, S., Eliassen, A. H., Chen, W. Y., Willett, W. C., & Cho, E. (2017). Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake. American Journal of Epidemiology, 186(5), pp. 524-531. doi:10.1093/aje/kwx137.
    Kim HJ, et al. Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake. Am J Epidemiol. 2017 Sep 1;186(5):524-531. PubMed PMID: 28520842.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol Consumption and Breast Cancer Risk in Younger Women According to Family History of Breast Cancer and Folate Intake. AU - Kim,Hyun Ja, AU - Jung,Seungyoun, AU - Eliassen,A Heather, AU - Chen,Wendy Y, AU - Willett,Walter C, AU - Cho,Eunyoung, PY - 2016/05/29/received PY - 2016/10/17/accepted PY - 2017/5/19/pubmed PY - 2017/10/4/medline PY - 2017/5/19/entrez KW - alcohol drinking KW - breast cancer KW - family history KW - folate KW - women SP - 524 EP - 531 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 186 IS - 5 N2 - To evaluate the association between alcohol consumption and breast cancer risk in younger women, overall and by family history of breast cancer and folate intake, we prospectively followed 93,835 US women aged 27-44 years in Nurses' Health Study II who had alcohol consumption data in 1991. Alcohol consumption and folate intake were measured by food frequency questionnaire every 4 years. We documented 2,866 incident cases of invasive breast cancer between 1991 and 2011. Alcohol consumption was not associated with breast cancer risk overall (for intake of ≥10 g/day vs. nondrinking, multivariate hazard ratio = 1.07, 95% confidence interval: 0.94, 1.22). When the association was stratified by family history and folate intake, a positive association between alcohol consumption and breast cancer was found among women with a family history and folate intake less than 400 μg/day (multivariate hazard ratio = 1.82, 95% confidence interval: 1.06, 3.12; P-trend = 0.08). Alcohol consumption was not associated with breast cancer in other categories of family history and folate intake (P-interaction = 0.55). In conclusion, in this population of younger women, higher alcohol consumption was associated with increased risk of breast cancer among those with both a family history of breast cancer and lower folate intake. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/28520842/Alcohol_Consumption_and_Breast_Cancer_Risk_in_Younger_Women_According_to_Family_History_of_Breast_Cancer_and_Folate_Intake_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwx137 DB - PRIME DP - Unbound Medicine ER -