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The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects.
Eur Respir J. 1988 Dec; 1(10):913-7.ER

Abstract

The relative bronchoconstricting potencies of leukotriene E4 (LTE4) methacholine and histamine have been compared in asthmatic and normal subjects. LTE4 responsiveness in asthmatic subjects, as measured by the dose which produced a 35% fall in specific airways conductance (PD35), ranged from 0.06-24.4 nmol (geom mean 4.1 nmol, n = 20). This was significantly less than the PD35 in normal subjects (range 39.0-370 nmol, geom mean 105 nmol, n= 6; p less than 0.001). There was a correlation between LTE4 and methacholine responsiveness (r = 0.84, p less than 0.001) and between LTE4 and histamine responsiveness (r = 0.79, p less than 0.001). LTE4 was 73 times more potent than methacholine and 112 times more potent than histamine in asthmatic subjects. LTE4 was 20 times more potent than methacholine and 58 times more potent than histamine in normal subjects. LTE4 is a potent bronchoconstrictor agent, and LTE4 responsiveness correlates with both histamine and methacholine responsiveness.

Authors+Show Affiliations

Department of Medicine, United Medical School, Guy's Hospital, London, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2852123

Citation

O'Hickey, S P., et al. "The Relative Responsiveness to Inhaled Leukotriene E4, Methacholine and Histamine in Normal and Asthmatic Subjects." The European Respiratory Journal, vol. 1, no. 10, 1988, pp. 913-7.
O'Hickey SP, Arm JP, Rees PJ, et al. The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects. Eur Respir J. 1988;1(10):913-7.
O'Hickey, S. P., Arm, J. P., Rees, P. J., Spur, B. W., & Lee, T. H. (1988). The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects. The European Respiratory Journal, 1(10), 913-7.
O'Hickey SP, et al. The Relative Responsiveness to Inhaled Leukotriene E4, Methacholine and Histamine in Normal and Asthmatic Subjects. Eur Respir J. 1988;1(10):913-7. PubMed PMID: 2852123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relative responsiveness to inhaled leukotriene E4, methacholine and histamine in normal and asthmatic subjects. AU - O'Hickey,S P, AU - Arm,J P, AU - Rees,P J, AU - Spur,B W, AU - Lee,T H, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 913 EP - 7 JF - The European respiratory journal JO - Eur Respir J VL - 1 IS - 10 N2 - The relative bronchoconstricting potencies of leukotriene E4 (LTE4) methacholine and histamine have been compared in asthmatic and normal subjects. LTE4 responsiveness in asthmatic subjects, as measured by the dose which produced a 35% fall in specific airways conductance (PD35), ranged from 0.06-24.4 nmol (geom mean 4.1 nmol, n = 20). This was significantly less than the PD35 in normal subjects (range 39.0-370 nmol, geom mean 105 nmol, n= 6; p less than 0.001). There was a correlation between LTE4 and methacholine responsiveness (r = 0.84, p less than 0.001) and between LTE4 and histamine responsiveness (r = 0.79, p less than 0.001). LTE4 was 73 times more potent than methacholine and 112 times more potent than histamine in asthmatic subjects. LTE4 was 20 times more potent than methacholine and 58 times more potent than histamine in normal subjects. LTE4 is a potent bronchoconstrictor agent, and LTE4 responsiveness correlates with both histamine and methacholine responsiveness. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/2852123/The_relative_responsiveness_to_inhaled_leukotriene_E4_methacholine_and_histamine_in_normal_and_asthmatic_subjects_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -