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Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort.
Psychol Med 2018; 48(1):61-71PM

Abstract

BACKGROUND

Cognitive reserve (CR) has been associated with better cognitive function and lower risk of depression in older people, yet it remains unclear whether CR moderates the association between mood and cognition. This study aimed to investigate whether a comprehensive indicator of CR, including education, occupation and engagement in cognitive and social activities, acts as a moderator of this association.

METHODS

This was a cross-sectional study utilising baseline data from the Cognitive Function and Ageing Study II (CFAS II), a large population-based cohort of people aged 65+ in England. Complete data on the measures of CR, mood and cognition were available for 6565 dementia-free individuals. Linear regression models were used to investigate the potential modifying effect of CR on the association between cognition and mood with adjustment for age, sex and missing data.

RESULTS

Levels of CR did moderate the negative association between mood and cognition; the difference in cognition between those with and without a clinical level mood disorder was significantly smaller in the middle (-2.28; 95% confidence interval (CI) -3.65 to -0.90) and higher (-1.30; 95% CI -2.46 to -0.15) CR groups compared with the lower CR group (-4.01; 95% CI -5.53 to -2.49). The individual components of CR did not significantly moderate the negative association between mood and cognition.

CONCLUSION

These results demonstrate that CR, indexed by a composite score based on multiple indicators, can moderate the negative association between lowered mood and cognition, emphasising the importance of continuing to build CR across the lifespan in order to maintain cognitive health.

Authors+Show Affiliations

Department of Psychology,Manchester Metropolitan University,Manchester,UK.Institute for Health and Society,Newcastle University,Newcastle,UK.REACH: The Centre for Research in Ageing and Cognitive Health,School of Psychology,University of Exeter,Exeter,UK.DSDC Wales,Bangor University,Bangor,UK.Department of Public Health and Primary Care,Cambridge Institute of Public Health,School of Clinical Medicine,University of Cambridge,Cambridge,UK.REACH: The Centre for Research in Ageing and Cognitive Health,School of Psychology,University of Exeter,Exeter,UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28521844

Citation

Opdebeeck, C, et al. "Cognitive Reserve as a Moderator of the Negative Association Between Mood and Cognition: Evidence From a Population-representative Cohort." Psychological Medicine, vol. 48, no. 1, 2018, pp. 61-71.
Opdebeeck C, Matthews FE, Wu YT, et al. Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort. Psychol Med. 2018;48(1):61-71.
Opdebeeck, C., Matthews, F. E., Wu, Y. T., Woods, R. T., Brayne, C., & Clare, L. (2018). Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort. Psychological Medicine, 48(1), pp. 61-71. doi:10.1017/S003329171700126X.
Opdebeeck C, et al. Cognitive Reserve as a Moderator of the Negative Association Between Mood and Cognition: Evidence From a Population-representative Cohort. Psychol Med. 2018;48(1):61-71. PubMed PMID: 28521844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort. AU - Opdebeeck,C, AU - Matthews,F E, AU - Wu,Y-T, AU - Woods,R T, AU - Brayne,C, AU - Clare,L, Y1 - 2017/05/19/ PY - 2017/5/20/pubmed PY - 2018/8/7/medline PY - 2017/5/20/entrez KW - Anxiety KW - cognitive activity KW - depression KW - education KW - occupation KW - social activity SP - 61 EP - 71 JF - Psychological medicine JO - Psychol Med VL - 48 IS - 1 N2 - BACKGROUND: Cognitive reserve (CR) has been associated with better cognitive function and lower risk of depression in older people, yet it remains unclear whether CR moderates the association between mood and cognition. This study aimed to investigate whether a comprehensive indicator of CR, including education, occupation and engagement in cognitive and social activities, acts as a moderator of this association. METHODS: This was a cross-sectional study utilising baseline data from the Cognitive Function and Ageing Study II (CFAS II), a large population-based cohort of people aged 65+ in England. Complete data on the measures of CR, mood and cognition were available for 6565 dementia-free individuals. Linear regression models were used to investigate the potential modifying effect of CR on the association between cognition and mood with adjustment for age, sex and missing data. RESULTS: Levels of CR did moderate the negative association between mood and cognition; the difference in cognition between those with and without a clinical level mood disorder was significantly smaller in the middle (-2.28; 95% confidence interval (CI) -3.65 to -0.90) and higher (-1.30; 95% CI -2.46 to -0.15) CR groups compared with the lower CR group (-4.01; 95% CI -5.53 to -2.49). The individual components of CR did not significantly moderate the negative association between mood and cognition. CONCLUSION: These results demonstrate that CR, indexed by a composite score based on multiple indicators, can moderate the negative association between lowered mood and cognition, emphasising the importance of continuing to build CR across the lifespan in order to maintain cognitive health. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/28521844/Cognitive_reserve_as_a_moderator_of_the_negative_association_between_mood_and_cognition:_evidence_from_a_population_representative_cohort_ L2 - https://www.cambridge.org/core/product/identifier/S003329171700126X/type/journal_article DB - PRIME DP - Unbound Medicine ER -