Citation
Crnošija, Luka, et al. "Differences in Neurohumoral and Hemodynamic Response to Prolonged Head-up Tilt Between Patients With High and Normal Standing Norepinephrine Forms of Postural Orthostatic Tachycardia Syndrome." Autonomic Neuroscience : Basic & Clinical, vol. 205, 2017, pp. 110-114.
Crnošija L, Krbot Skorić M, Lovrić M, et al. Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome. Auton Neurosci. 2017;205:110-114.
Crnošija, L., Krbot Skorić, M., Lovrić, M., Junaković, A., Miletić, V., Alfirev, R. Š., Pavelić, A., Adamec, I., & Habek, M. (2017). Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome. Autonomic Neuroscience : Basic & Clinical, 205, 110-114. https://doi.org/10.1016/j.autneu.2017.05.007
Crnošija L, et al. Differences in Neurohumoral and Hemodynamic Response to Prolonged Head-up Tilt Between Patients With High and Normal Standing Norepinephrine Forms of Postural Orthostatic Tachycardia Syndrome. Auton Neurosci. 2017;205:110-114. PubMed PMID: 28522107.
TY - JOUR
T1 - Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome.
AU - Crnošija,Luka,
AU - Krbot Skorić,Magdalena,
AU - Lovrić,Mila,
AU - Junaković,Anamari,
AU - Miletić,Vladimir,
AU - Alfirev,Rujana Šprljan,
AU - Pavelić,Antun,
AU - Adamec,Ivan,
AU - Habek,Mario,
Y1 - 2017/05/11/
PY - 2016/12/28/received
PY - 2017/04/18/revised
PY - 2017/05/10/accepted
PY - 2017/5/20/pubmed
PY - 2017/12/13/medline
PY - 2017/5/20/entrez
KW - Dopamine
KW - Epinephrine
KW - High standing NE
KW - Norepinephrine
KW - Postural orthostatic tachycardia syndrome
SP - 110
EP - 114
JF - Autonomic neuroscience : basic & clinical
JO - Auton Neurosci
VL - 205
N2 - OBJECTIVE: To investigate the optimal timing for blood sample collection of catecholamines and the possible correlations between neurohumoral and hemodynamic responses to prolonged head-up tilt (HUT) in postural orthostatic tachycardia syndrome (POTS). METHODS: Nineteen patients underwent a 30-minute, 70° HUT test. Blood samples (norepinephrine (NE), epinephrine and dopamine) were taken in the 10th minute of supine, and 10th, 20th and 30th minutes of HUT. RESULTS: There were no significant differences in the proportion of high and normal standing NE patients in the different time points. Mean NE (nmol/L) values in 10th, 20th and 30th minute of HUT were 4.37, 4.87, and 4.35 in the high standing NE, and 2.49, 2.59 and 2.88 in the normal standing NE group. High standing NE patients had higher blood pressure (BP) during the first 6min of HUT (2nd minute after the HUT systolic BP (sBP): 118.29±15.65 vs. 95.70±13.43, p=0.004; diastolic BP (dBP): 78.71±6.68 vs. 65.10±9.04, p=0.003), while normal standing NE patients exhibited a drop in BP compared to resting values during the same time period. The normal standing NE group exhibited a progressive increase in norepinephrine values during the HUT. CONCLUSION: One blood sample taken at the 10th minute of HUT correctly identifies high and normal standing NE POTS patients, but a small number of patients (1 out of 19, 5.2%) can be misidentified. High and normal standing NE POTS patients display distinctly different neurohumoral and hemodynamic responses to HUT.
SN - 1872-7484
UR - https://www.unboundmedicine.com/medline/citation/28522107/Differences_in_neurohumoral_and_hemodynamic_response_to_prolonged_head_up_tilt_between_patients_with_high_and_normal_standing_norepinephrine_forms_of_postural_orthostatic_tachycardia_syndrome_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(16)30310-1
DB - PRIME
DP - Unbound Medicine
ER -
