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Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults.
Alzheimers Dement. 2017 Nov; 13(11):1207-1216.AD

Abstract

INTRODUCTION

Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.

METHODS

The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.

RESULTS

In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97).

DISCUSSION

This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.

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Authors+Show Affiliations

Feart C
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France. Electronic address: Catherine.Feart-Couret@u-bordeaux.fr.
Helmer C
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Merle B
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Herrmann FR
Department of Rehabilitation and Geriatrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
Annweiler C
Pôle de Neurosciences, Service de Gériatrie, Centre Hospitalier Universitaire d'Angers, Centre Mémoire Ressources Recherche, Centre de Recherche sur l'Autonomie et la Longévité (CeRAL), UPRES EA 4638, Université d'Angers, UNAM, Angers, France; Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.
Dartigues JF
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Delcourt C
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.
Samieri C
INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.

MeSH

AgedAged, 80 and overAlzheimer DiseaseCognition DisordersCohort StudiesDementiaFemaleHumansKaplan-Meier EstimateMaleMultivariate AnalysisNeuropsychological TestsVitamin D

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28522216

Citation

Feart, Catherine, et al. "Associations of Lower Vitamin D Concentrations With Cognitive Decline and Long-term Risk of Dementia and Alzheimer's Disease in Older Adults." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 13, no. 11, 2017, pp. 1207-1216.
Feart C, Helmer C, Merle B, et al. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimers Dement. 2017;13(11):1207-1216.
Feart, C., Helmer, C., Merle, B., Herrmann, F. R., Annweiler, C., Dartigues, J. F., Delcourt, C., & Samieri, C. (2017). Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 13(11), 1207-1216. https://doi.org/10.1016/j.jalz.2017.03.003
Feart C, et al. Associations of Lower Vitamin D Concentrations With Cognitive Decline and Long-term Risk of Dementia and Alzheimer's Disease in Older Adults. Alzheimers Dement. 2017;13(11):1207-1216. PubMed PMID: 28522216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. AU - Feart,Catherine, AU - Helmer,Catherine, AU - Merle,Bénédicte, AU - Herrmann,François R, AU - Annweiler,Cédric, AU - Dartigues,Jean-François, AU - Delcourt,Cécile, AU - Samieri,Cécilia, Y1 - 2017/05/16/ PY - 2016/10/04/received PY - 2017/03/02/revised PY - 2017/03/02/accepted PY - 2017/5/20/pubmed PY - 2018/6/19/medline PY - 2017/5/20/entrez KW - Alzheimer's disease KW - Cognitive decline KW - Dementia KW - Prospective studies KW - Risk factors in epidemiology KW - Vitamin D SP - 1207 EP - 1216 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 13 IS - 11 N2 - INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/28522216/Associations_of_lower_vitamin_D_concentrations_with_cognitive_decline_and_long_term_risk_of_dementia_and_Alzheimer's_disease_in_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(17)30138-3 DB - PRIME DP - Unbound Medicine ER -