Citation
Feart, Catherine, et al. "Associations of Lower Vitamin D Concentrations With Cognitive Decline and Long-term Risk of Dementia and Alzheimer's Disease in Older Adults." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 13, no. 11, 2017, pp. 1207-1216.
Feart C, Helmer C, Merle B, et al. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimers Dement. 2017;13(11):1207-1216.
Feart, C., Helmer, C., Merle, B., Herrmann, F. R., Annweiler, C., Dartigues, J. F., Delcourt, C., & Samieri, C. (2017). Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 13(11), 1207-1216. https://doi.org/10.1016/j.jalz.2017.03.003
Feart C, et al. Associations of Lower Vitamin D Concentrations With Cognitive Decline and Long-term Risk of Dementia and Alzheimer's Disease in Older Adults. Alzheimers Dement. 2017;13(11):1207-1216. PubMed PMID: 28522216.
TY - JOUR
T1 - Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults.
AU - Feart,Catherine,
AU - Helmer,Catherine,
AU - Merle,Bénédicte,
AU - Herrmann,François R,
AU - Annweiler,Cédric,
AU - Dartigues,Jean-François,
AU - Delcourt,Cécile,
AU - Samieri,Cécilia,
Y1 - 2017/05/16/
PY - 2016/10/04/received
PY - 2017/03/02/revised
PY - 2017/03/02/accepted
PY - 2017/5/20/pubmed
PY - 2018/6/19/medline
PY - 2017/5/20/entrez
KW - Alzheimer's disease
KW - Cognitive decline
KW - Dementia
KW - Prospective studies
KW - Risk factors in epidemiology
KW - Vitamin D
SP - 1207
EP - 1216
JF - Alzheimer's & dementia : the journal of the Alzheimer's Association
JO - Alzheimers Dement
VL - 13
IS - 11
N2 - INTRODUCTION: Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent. METHODS: The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years. RESULTS: In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95% confidence interval 1.37-5.97). DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology.
SN - 1552-5279
UR - https://www.unboundmedicine.com/medline/citation/28522216/Associations_of_lower_vitamin_D_concentrations_with_cognitive_decline_and_long_term_risk_of_dementia_and_Alzheimer's_disease_in_older_adults_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(17)30138-3
DB - PRIME
DP - Unbound Medicine
ER -