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Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.
Bioorg Med Chem. 2017 07 01; 25(13):3567-3573.BM

Abstract

A novel series of acyl selenoureido benzensulfonamides was evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, VII and IX, which are involved in a variety of diseases such as glaucoma, retinitis pigmentosa, epilepsy and tumors etc. These compounds showed excellent inhibitory activity for these isoforms, with several low nanomolar derivatives identified against all of them. Furthermore, the selenoureido group may provide an antioxidant activity to these enzyme inhibitors.

Authors+Show Affiliations

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28522267

Citation

Angeli, Andrea, et al. "Synthesis of Novel Acyl Selenoureido Benzensulfonamides as Carbonic Anhydrase I, II, VII and IX Inhibitors." Bioorganic & Medicinal Chemistry, vol. 25, no. 13, 2017, pp. 3567-3573.
Angeli A, Carta F, Bartolucci G, et al. Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors. Bioorg Med Chem. 2017;25(13):3567-3573.
Angeli, A., Carta, F., Bartolucci, G., & Supuran, C. T. (2017). Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors. Bioorganic & Medicinal Chemistry, 25(13), 3567-3573. https://doi.org/10.1016/j.bmc.2017.05.014
Angeli A, et al. Synthesis of Novel Acyl Selenoureido Benzensulfonamides as Carbonic Anhydrase I, II, VII and IX Inhibitors. Bioorg Med Chem. 2017 07 1;25(13):3567-3573. PubMed PMID: 28522267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors. AU - Angeli,Andrea, AU - Carta,Fabrizio, AU - Bartolucci,Gianluca, AU - Supuran,Claudiu T, Y1 - 2017/05/09/ PY - 2017/03/29/received PY - 2017/05/03/revised PY - 2017/05/05/accepted PY - 2017/5/20/pubmed PY - 2017/8/5/medline PY - 2017/5/20/entrez KW - Acylseleno-urea KW - Carbonic anhydrase KW - Inhibitors KW - Metalloenzymes KW - Selenium SP - 3567 EP - 3573 JF - Bioorganic & medicinal chemistry JO - Bioorg. Med. Chem. VL - 25 IS - 13 N2 - A novel series of acyl selenoureido benzensulfonamides was evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, VII and IX, which are involved in a variety of diseases such as glaucoma, retinitis pigmentosa, epilepsy and tumors etc. These compounds showed excellent inhibitory activity for these isoforms, with several low nanomolar derivatives identified against all of them. Furthermore, the selenoureido group may provide an antioxidant activity to these enzyme inhibitors. SN - 1464-3391 UR - https://www.unboundmedicine.com/medline/citation/28522267/Synthesis_of_novel_acyl_selenoureido_benzensulfonamides_as_carbonic_anhydrase_I_II_VII_and_IX_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0968-0896(17)30656-9 DB - PRIME DP - Unbound Medicine ER -