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Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7).
Methods Find Exp Clin Pharmacol. 1988 Aug; 10(8):513-20.MF

Abstract

Cholecystokinin 7 (CCK 7), a synthetic analogue of cholecystokinin/pancreozymin (CCK 33), increased in a dose-dependent manner the tone of the guinea-pig ileal, gastric and gall bladder smooth muscle preparations. In all these preparations CCK 7 was more potent than CCK 8 and CCK 33 and all three cholecystokinins were more potent than acetylcholine (ACH). Atropine and tetrodotoxin (TTX) did not influence the CCK 7 action in fundus and gall bladder muscle strips but reduced non-competitively its effect in ileal muscle strips. Neither GE 410 nor dbcGMP affected the ACH and histamine (His) response of the muscle strips but both antagonists shifted the dose-response curve of CCK 7 to the right, GE 410 (cholecystokinin antagonist) being a much more potent antagonist of CCK 7 as compared to dbcGMP. In all muscle strips a competitive action on the CCK 7 responses was found for GE 410. In gastric muscle strips a competitive influence on the CCK 7 responses was found for dbcGMP at low concentration (1 x 10(-5)M) and a non-competitive influence at high concentration (5 x 10(-4)M). The results suggest that the contractile effects of CCK 7 in the isolated ileal smooth muscle are realized by cholinergic and direct myogenic mechanisms, whereas in the isolated gall bladder and gastric smooth muscles, by a direct myogenic mechanism only.

Authors+Show Affiliations

Institute of Drug Research, Academy of Sciences, Berlin-GDR.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2852288

Citation

Nieber, K, et al. "Responses of Guinea-pig Gastric, Ileal and Gall Bladder Smooth Muscle to Desamino-cholecystokinin-octapeptide (CCK 7)." Methods and Findings in Experimental and Clinical Pharmacology, vol. 10, no. 8, 1988, pp. 513-20.
Nieber K, Milenov K, Rakovska A, et al. Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7). Methods Find Exp Clin Pharmacol. 1988;10(8):513-20.
Nieber, K., Milenov, K., Rakovska, A., Henklein, P., & Oehme, P. (1988). Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7). Methods and Findings in Experimental and Clinical Pharmacology, 10(8), 513-20.
Nieber K, et al. Responses of Guinea-pig Gastric, Ileal and Gall Bladder Smooth Muscle to Desamino-cholecystokinin-octapeptide (CCK 7). Methods Find Exp Clin Pharmacol. 1988;10(8):513-20. PubMed PMID: 2852288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Responses of guinea-pig gastric, ileal and gall bladder smooth muscle to desamino-cholecystokinin-octapeptide (CCK 7). AU - Nieber,K, AU - Milenov,K, AU - Rakovska,A, AU - Henklein,P, AU - Oehme,P, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 513 EP - 20 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 10 IS - 8 N2 - Cholecystokinin 7 (CCK 7), a synthetic analogue of cholecystokinin/pancreozymin (CCK 33), increased in a dose-dependent manner the tone of the guinea-pig ileal, gastric and gall bladder smooth muscle preparations. In all these preparations CCK 7 was more potent than CCK 8 and CCK 33 and all three cholecystokinins were more potent than acetylcholine (ACH). Atropine and tetrodotoxin (TTX) did not influence the CCK 7 action in fundus and gall bladder muscle strips but reduced non-competitively its effect in ileal muscle strips. Neither GE 410 nor dbcGMP affected the ACH and histamine (His) response of the muscle strips but both antagonists shifted the dose-response curve of CCK 7 to the right, GE 410 (cholecystokinin antagonist) being a much more potent antagonist of CCK 7 as compared to dbcGMP. In all muscle strips a competitive action on the CCK 7 responses was found for GE 410. In gastric muscle strips a competitive influence on the CCK 7 responses was found for dbcGMP at low concentration (1 x 10(-5)M) and a non-competitive influence at high concentration (5 x 10(-4)M). The results suggest that the contractile effects of CCK 7 in the isolated ileal smooth muscle are realized by cholinergic and direct myogenic mechanisms, whereas in the isolated gall bladder and gastric smooth muscles, by a direct myogenic mechanism only. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/2852288/Responses_of_guinea_pig_gastric_ileal_and_gall_bladder_smooth_muscle_to_desamino_cholecystokinin_octapeptide__CCK_7__ DB - PRIME DP - Unbound Medicine ER -