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Effects of various vanadium compounds on cochlear potentials.
Acta Otolaryngol Suppl. 1988; 456:132-6.AO

Abstract

The effects of vanadium compounds, sodium vanadate, ammonium vanadate, potassium vanadate, vanadium oxysulfate, vanadium acetylacetonate, and vanadium trichloride, on endocochlear potential (EP) and cochlear microphonic potential (CM) were examined in the guinea pig cochlea. The perilymphatic space was perfused for 30 min with 1 mM solution of each compound and changes of EP, CM, and negative EP were observed. Upon perfusion with pentavalent vanadium solutions, such as sodium vanadate, ammonium vanadate, and potassium vanadate, the EP showed an overshoot at the beginning of perfusion and then a gradual decrease, while the CM showed only a gradual decrease. The other compounds had no effects on EP and CM. Since the negative EP showed no differences due to perfusion of any compound, it is concluded that the vanadate compounds have inhibitory effects on EP primarily, and on CM only secondarily. The chemical mechanism of the effects of vanadates was discussed concerning the function of the stria vascularis and also its participation in acute hearing loss.

Authors+Show Affiliations

Kagoshima Immaculate Heart College, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2852429

Citation

Nakano, T, and T Morimitsu. "Effects of Various Vanadium Compounds On Cochlear Potentials." Acta Oto-laryngologica. Supplementum, vol. 456, 1988, pp. 132-6.
Nakano T, Morimitsu T. Effects of various vanadium compounds on cochlear potentials. Acta Otolaryngol Suppl. 1988;456:132-6.
Nakano, T., & Morimitsu, T. (1988). Effects of various vanadium compounds on cochlear potentials. Acta Oto-laryngologica. Supplementum, 456, 132-6.
Nakano T, Morimitsu T. Effects of Various Vanadium Compounds On Cochlear Potentials. Acta Otolaryngol Suppl. 1988;456:132-6. PubMed PMID: 2852429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of various vanadium compounds on cochlear potentials. AU - Nakano,T, AU - Morimitsu,T, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 132 EP - 6 JF - Acta oto-laryngologica. Supplementum JO - Acta Otolaryngol Suppl VL - 456 N2 - The effects of vanadium compounds, sodium vanadate, ammonium vanadate, potassium vanadate, vanadium oxysulfate, vanadium acetylacetonate, and vanadium trichloride, on endocochlear potential (EP) and cochlear microphonic potential (CM) were examined in the guinea pig cochlea. The perilymphatic space was perfused for 30 min with 1 mM solution of each compound and changes of EP, CM, and negative EP were observed. Upon perfusion with pentavalent vanadium solutions, such as sodium vanadate, ammonium vanadate, and potassium vanadate, the EP showed an overshoot at the beginning of perfusion and then a gradual decrease, while the CM showed only a gradual decrease. The other compounds had no effects on EP and CM. Since the negative EP showed no differences due to perfusion of any compound, it is concluded that the vanadate compounds have inhibitory effects on EP primarily, and on CM only secondarily. The chemical mechanism of the effects of vanadates was discussed concerning the function of the stria vascularis and also its participation in acute hearing loss. SN - 0365-5237 UR - https://www.unboundmedicine.com/medline/citation/2852429/Effects_of_various_vanadium_compounds_on_cochlear_potentials_ DB - PRIME DP - Unbound Medicine ER -