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Analysis of electroencephalogram characteristics of anti-NMDA receptor encephalitis patients in China.
Clin Neurophysiol. 2017 07; 128(7):1227-1233.CN

Abstract

OBJECTIVE

To explore the characteristics of electroencephalogram (EEG) in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis.

METHODS

Anti-NMDAR encephalitis patients admitted to the Department of Neurology between January 2012 and June 2016 were enrolled. All patients underwent electroencephalogram (EEG) at least once in the disease peak stage, and received tumor screening, symptomatic therapy, and immunotherapy. Patients received outcome evaluation every 6months after the immunotherapy, and modified Rankin scale (mRS) 0-2 was defined as favorable outcome.

RESULTS

This study enrolled 62 cases of anti-NMDAR encephalitis patients, including 29 males (46.8%) and 33 females (53.2%). The patient ages were between 10 and 59 (mean 26.3±11.3) years. A total of 93 instances of EEG monitoring were performed on 62 patients. At the peak stage, EEG presentations showed 61 cases (98.4%) were abnormal, cranial MRI showed 29 cases (46.8%) were abnormal among all 62 patients. The main presentations of abnormal EEG were diffuse slowing (25 cases, 40.3%), epileptiform discharges (11 cases, 17.7%), extreme delta brush (EDB) (10 cases, 16.1%), polymorphic delta rhythm (6 cases, 9.7%), focal slowing (5 cases, 8.1%), and diffuse beta activities (4 cases, 6.5%). Patients with normal background, epileptiform discharges, polymorphic delta rhythm, and diffuse beta activity in EEG all had favorable long-term outcome.

CONCLUSIONS

The majority of anti-NMDAR encephalitis patients had abnormal EEG. EEG could sensitively reflect the abnormal brain functions of patients and could assist with early clinical diagnosis and prognosis prediction.

SIGNIFICANCE

Diffuse slowing was the most common presentation on the EEG in patients with anti-NMDAR encephalitis. The EEG pattern of normal background, epileptiform discharges, polymorphic delta rhythm, and diffuse beta activities at the peak stage might suggest favorable long-term prognosis.

Authors+Show Affiliations

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address: zhangyanxwyy@sina.com.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28527387

Citation

Zhang, Yan, et al. "Analysis of Electroencephalogram Characteristics of anti-NMDA Receptor Encephalitis Patients in China." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 128, no. 7, 2017, pp. 1227-1233.
Zhang Y, Liu G, Jiang MD, et al. Analysis of electroencephalogram characteristics of anti-NMDA receptor encephalitis patients in China. Clin Neurophysiol. 2017;128(7):1227-1233.
Zhang, Y., Liu, G., Jiang, M. D., Li, L. P., & Su, Y. Y. (2017). Analysis of electroencephalogram characteristics of anti-NMDA receptor encephalitis patients in China. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 128(7), 1227-1233. https://doi.org/10.1016/j.clinph.2017.04.015
Zhang Y, et al. Analysis of Electroencephalogram Characteristics of anti-NMDA Receptor Encephalitis Patients in China. Clin Neurophysiol. 2017;128(7):1227-1233. PubMed PMID: 28527387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of electroencephalogram characteristics of anti-NMDA receptor encephalitis patients in China. AU - Zhang,Yan, AU - Liu,Gang, AU - Jiang,Meng Di, AU - Li,Li Ping, AU - Su,Ying Ying, Y1 - 2017/05/04/ PY - 2016/12/31/received PY - 2017/03/11/revised PY - 2017/04/19/accepted PY - 2017/5/21/pubmed PY - 2017/8/22/medline PY - 2017/5/21/entrez KW - Anti-N-methyl-d-aspartate receptor encephalitis KW - Characteristics KW - Electroencephalogram KW - Prognosis SP - 1227 EP - 1233 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 128 IS - 7 N2 - OBJECTIVE: To explore the characteristics of electroencephalogram (EEG) in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. METHODS: Anti-NMDAR encephalitis patients admitted to the Department of Neurology between January 2012 and June 2016 were enrolled. All patients underwent electroencephalogram (EEG) at least once in the disease peak stage, and received tumor screening, symptomatic therapy, and immunotherapy. Patients received outcome evaluation every 6months after the immunotherapy, and modified Rankin scale (mRS) 0-2 was defined as favorable outcome. RESULTS: This study enrolled 62 cases of anti-NMDAR encephalitis patients, including 29 males (46.8%) and 33 females (53.2%). The patient ages were between 10 and 59 (mean 26.3±11.3) years. A total of 93 instances of EEG monitoring were performed on 62 patients. At the peak stage, EEG presentations showed 61 cases (98.4%) were abnormal, cranial MRI showed 29 cases (46.8%) were abnormal among all 62 patients. The main presentations of abnormal EEG were diffuse slowing (25 cases, 40.3%), epileptiform discharges (11 cases, 17.7%), extreme delta brush (EDB) (10 cases, 16.1%), polymorphic delta rhythm (6 cases, 9.7%), focal slowing (5 cases, 8.1%), and diffuse beta activities (4 cases, 6.5%). Patients with normal background, epileptiform discharges, polymorphic delta rhythm, and diffuse beta activity in EEG all had favorable long-term outcome. CONCLUSIONS: The majority of anti-NMDAR encephalitis patients had abnormal EEG. EEG could sensitively reflect the abnormal brain functions of patients and could assist with early clinical diagnosis and prognosis prediction. SIGNIFICANCE: Diffuse slowing was the most common presentation on the EEG in patients with anti-NMDAR encephalitis. The EEG pattern of normal background, epileptiform discharges, polymorphic delta rhythm, and diffuse beta activities at the peak stage might suggest favorable long-term prognosis. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/28527387/Analysis_of_electroencephalogram_characteristics_of_anti_NMDA_receptor_encephalitis_patients_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(17)30161-X DB - PRIME DP - Unbound Medicine ER -