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Sodium Channels and Venom Peptide Pharmacology.
Adv Pharmacol. 2017; 79:67-116.AP

Abstract

Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads. Here, we review our understanding of the basic function of mammalian voltage-gated sodium channel isoforms as well as the pharmacology of venom peptides that act at these key transmembrane proteins.

Authors+Show Affiliations

Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia. Electronic address: j.deuis@uq.edu.au.Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia; School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia. Electronic address: i.vetter@uq.edu.au.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28528674

Citation

Israel, Mathilde R., et al. "Sodium Channels and Venom Peptide Pharmacology." Advances in Pharmacology (San Diego, Calif.), vol. 79, 2017, pp. 67-116.
Israel MR, Tay B, Deuis JR, et al. Sodium Channels and Venom Peptide Pharmacology. Adv Pharmacol. 2017;79:67-116.
Israel, M. R., Tay, B., Deuis, J. R., & Vetter, I. (2017). Sodium Channels and Venom Peptide Pharmacology. Advances in Pharmacology (San Diego, Calif.), 79, 67-116. https://doi.org/10.1016/bs.apha.2017.01.004
Israel MR, et al. Sodium Channels and Venom Peptide Pharmacology. Adv Pharmacol. 2017;79:67-116. PubMed PMID: 28528674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sodium Channels and Venom Peptide Pharmacology. AU - Israel,Mathilde R, AU - Tay,Bryan, AU - Deuis,Jennifer R, AU - Vetter,Irina, Y1 - 2017/04/08/ PY - 2017/5/23/entrez PY - 2017/5/23/pubmed PY - 2017/12/21/medline KW - Conotoxins KW - Gating modifier toxins KW - Pore blockers KW - Scorpion toxins KW - Spider venom peptides KW - Venom peptide KW - Voltage-gated sodium channel SP - 67 EP - 116 JF - Advances in pharmacology (San Diego, Calif.) JO - Adv. Pharmacol. VL - 79 N2 - Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have evolved a myriad of components in their venoms that target the opening and/or closing of voltage-gated sodium channels to cause devastating effects on the neuromuscular systems of predators and prey. These venom peptides, through design and serendipity, have not only contributed significantly to our understanding of sodium channel pharmacology and structure, but they also represent some of the most phyla- and isoform-selective molecules that are useful as valuable tool compounds and drug leads. Here, we review our understanding of the basic function of mammalian voltage-gated sodium channel isoforms as well as the pharmacology of venom peptides that act at these key transmembrane proteins. SN - 1557-8925 UR - https://www.unboundmedicine.com/medline/citation/28528674/Sodium_Channels_and_Venom_Peptide_Pharmacology_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1054-3589(17)30004-2 DB - PRIME DP - Unbound Medicine ER -