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Laparoscopic Roux-en-Y gastric bypass versus laparoscopic mini gastric bypass in the treatment of obesity: study protocol for a randomized controlled trial.
Trials. 2017 05 22; 18(1):226.T

Abstract

BACKGROUND

Laparoscopic Roux-en-Y gastric bypass (LRYGB) is considered the gold standard in bariatric surgery, achieving durable long-term weight loss with improvement of obesity-related comorbidities. Lately, the laparoscopic mini gastric bypass (LMGB) has gained worldwide popularity with similar results to LRYGB in terms of weight loss and comorbidity resolution. However, there is a lack of randomized controlled trials (RCT) comparing LMGB and LRYGB. This article describes the design and protocol of a randomized controlled trial comparing the outcomes of these two bariatric procedures.

METHODS/DESIGN

The trial is designed as a single center, randomized, patient and observer blinded trial. The relevant ethics committee has approved the trial protocol. To demonstrate that LMGB is not inferior to LRYGB in terms of excess weight loss (EWL) the study is conducted as a non-inferiority trial with the sample-size calculations performed accordingly. EWL 12 months after surgery is the primary endpoint, whereas 3-year EWL, morbidity, mortality, remission of obesity related comorbidities, quality of life (QOL) and hormonal and lipid profile changes are secondary endpoints. Eighty patients, 18 years or older and with a body mass index (BMI) between 35 and 50 kg/m2 who meet the Swiss guidelines for the surgical treatment of morbid obesity will be randomized. The endpoints and baseline measurements will be assessed pre-surgery, peri-surgery and post-surgery (fixed follow up measurements are at discharge and at the time points 6 weeks and 12 and 36 months postoperatively).

DISCUSSION

With its 3-year follow up time, this RCT will provide important data on the impact of LMGB and LRYGB on EWL, remission of comorbidities, QOL and hormonal and lipid profile changes.

TRIAL REGISTRATION

ClinicalTrials.gov, NCT02601092 . Registered on 28 September 2015.

Authors+Show Affiliations

Department of General Surgery, University Hospital Basel, 4031, Basel, Switzerland. marko.kraljevic@gmail.com.Department of General Surgery, University Hospital Basel, 4031, Basel, Switzerland.Department of General Surgery, Limmattal Hospital, 8952, Zurich-Schlieren, Switzerland.IFNH Laboratory of Translational Nutrition Biology, ETH Zurich, 8603, Schwerzenbach, Switzerland.Institute of Veterinary Physiology, Vetsuisse Faculty and Centre of Integrative Human Physiology, University of Zurich, 8057, Zurich, Switzerland.Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, 4031, Basel, Switzerland.Department of General Surgery, University Hospital Basel, 4031, Basel, Switzerland.Department of General Surgery, Ipswich General Hospital, Ipswich, Queensland, 4305, Australia.Department of General Surgery, University Hospital Basel, 4031, Basel, Switzerland.Department of General Surgery, Limmattal Hospital, 8952, Zurich-Schlieren, Switzerland.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28532499

Citation

Kraljević, Marko, et al. "Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Mini Gastric Bypass in the Treatment of Obesity: Study Protocol for a Randomized Controlled Trial." Trials, vol. 18, no. 1, 2017, p. 226.
Kraljević M, Delko T, Köstler T, et al. Laparoscopic Roux-en-Y gastric bypass versus laparoscopic mini gastric bypass in the treatment of obesity: study protocol for a randomized controlled trial. Trials. 2017;18(1):226.
Kraljević, M., Delko, T., Köstler, T., Osto, E., Lutz, T., Thommen, S., Droeser, R. A., Rothwell, L., Oertli, D., & Zingg, U. (2017). Laparoscopic Roux-en-Y gastric bypass versus laparoscopic mini gastric bypass in the treatment of obesity: study protocol for a randomized controlled trial. Trials, 18(1), 226. https://doi.org/10.1186/s13063-017-1957-9
Kraljević M, et al. Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Mini Gastric Bypass in the Treatment of Obesity: Study Protocol for a Randomized Controlled Trial. Trials. 2017 05 22;18(1):226. PubMed PMID: 28532499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic Roux-en-Y gastric bypass versus laparoscopic mini gastric bypass in the treatment of obesity: study protocol for a randomized controlled trial. AU - Kraljević,Marko, AU - Delko,Tarik, AU - Köstler,Thomas, AU - Osto,Elena, AU - Lutz,Thomas, AU - Thommen,Sarah, AU - Droeser,Raoul A, AU - Rothwell,Lincoln, AU - Oertli,Daniel, AU - Zingg,Urs, Y1 - 2017/05/22/ PY - 2016/11/09/received PY - 2017/04/27/accepted PY - 2017/5/24/entrez PY - 2017/5/24/pubmed PY - 2018/3/20/medline KW - Excess weight loss KW - Mini gastric bypass KW - Outcome KW - Randomized controlled trial KW - Roux-en-Y gastric bypass SP - 226 EP - 226 JF - Trials JO - Trials VL - 18 IS - 1 N2 - BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is considered the gold standard in bariatric surgery, achieving durable long-term weight loss with improvement of obesity-related comorbidities. Lately, the laparoscopic mini gastric bypass (LMGB) has gained worldwide popularity with similar results to LRYGB in terms of weight loss and comorbidity resolution. However, there is a lack of randomized controlled trials (RCT) comparing LMGB and LRYGB. This article describes the design and protocol of a randomized controlled trial comparing the outcomes of these two bariatric procedures. METHODS/DESIGN: The trial is designed as a single center, randomized, patient and observer blinded trial. The relevant ethics committee has approved the trial protocol. To demonstrate that LMGB is not inferior to LRYGB in terms of excess weight loss (EWL) the study is conducted as a non-inferiority trial with the sample-size calculations performed accordingly. EWL 12 months after surgery is the primary endpoint, whereas 3-year EWL, morbidity, mortality, remission of obesity related comorbidities, quality of life (QOL) and hormonal and lipid profile changes are secondary endpoints. Eighty patients, 18 years or older and with a body mass index (BMI) between 35 and 50 kg/m2 who meet the Swiss guidelines for the surgical treatment of morbid obesity will be randomized. The endpoints and baseline measurements will be assessed pre-surgery, peri-surgery and post-surgery (fixed follow up measurements are at discharge and at the time points 6 weeks and 12 and 36 months postoperatively). DISCUSSION: With its 3-year follow up time, this RCT will provide important data on the impact of LMGB and LRYGB on EWL, remission of comorbidities, QOL and hormonal and lipid profile changes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02601092 . Registered on 28 September 2015. SN - 1745-6215 UR - https://www.unboundmedicine.com/medline/citation/28532499/Laparoscopic_Roux_en_Y_gastric_bypass_versus_laparoscopic_mini_gastric_bypass_in_the_treatment_of_obesity:_study_protocol_for_a_randomized_controlled_trial_ L2 - https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-1957-9 DB - PRIME DP - Unbound Medicine ER -