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Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial.
Nutr J 2017; 16(1):33NJ

Abstract

BACKGROUND

Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status.

METHODS

In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA).

RESULTS

Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet.

CONCLUSION

The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance.

TRIAL REGISTRATION

ClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014.

Authors+Show Affiliations

Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK. Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK. Present address: School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK. Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.Animal, Dairy and Food Chain Sciences, University of Reading, Reading, RG6 6AP, UK.MRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK. NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, Cambridge, CB2 0QQ, UK.Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.MRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.MRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.Animal, Dairy and Food Chain Sciences, University of Reading, Reading, RG6 6AP, UK.Department of Mathematics and Statistics, School of Mathematical, Physical and Computational Sciences, University of Reading, Reading, RG6 6AX, UK.Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK. Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.Institute for Food, Nutrition and Health, University of Reading, Reading, RG6 6AR, UK.Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK. j.a.lovegrove@reading.ac.uk. Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK. j.a.lovegrove@reading.ac.uk. Institute for Food, Nutrition and Health, University of Reading, Reading, RG6 6AR, UK. j.a.lovegrove@reading.ac.uk.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28535777

Citation

Markey, Oonagh, et al. "Plasma Phospholipid Fatty Acid Profile Confirms Compliance to a Novel Saturated Fat-reduced, Monounsaturated Fat-enriched Dairy Product Intervention in Adults at Moderate Cardiovascular Risk: a Randomized Controlled Trial." Nutrition Journal, vol. 16, no. 1, 2017, p. 33.
Markey O, Vasilopoulou D, Kliem KE, et al. Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial. Nutr J. 2017;16(1):33.
Markey, O., Vasilopoulou, D., Kliem, K. E., Koulman, A., Fagan, C. C., Summerhill, K., ... Lovegrove, J. A. (2017). Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial. Nutrition Journal, 16(1), p. 33. doi:10.1186/s12937-017-0249-2.
Markey O, et al. Plasma Phospholipid Fatty Acid Profile Confirms Compliance to a Novel Saturated Fat-reduced, Monounsaturated Fat-enriched Dairy Product Intervention in Adults at Moderate Cardiovascular Risk: a Randomized Controlled Trial. Nutr J. 2017 May 23;16(1):33. PubMed PMID: 28535777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial. AU - Markey,Oonagh, AU - Vasilopoulou,Dafni, AU - Kliem,Kirsty E, AU - Koulman,Albert, AU - Fagan,Colette C, AU - Summerhill,Keith, AU - Wang,Laura Y, AU - Grandison,Alistair S, AU - Humphries,David J, AU - Todd,Susan, AU - Jackson,Kim G, AU - Givens,David I, AU - Lovegrove,Julie A, Y1 - 2017/05/23/ PY - 2017/02/10/received PY - 2017/05/03/accepted PY - 2017/5/25/entrez PY - 2017/5/26/pubmed PY - 2018/4/13/medline KW - Cardiovascular disease KW - Dairy products KW - Dietary fat composition KW - Fatty acids KW - Food-exchange model KW - Monounsaturated fatty acids KW - Nutrition assessment KW - Phospholipids KW - Saturated fatty acids SP - 33 EP - 33 JF - Nutrition journal JO - Nutr J VL - 16 IS - 1 N2 - BACKGROUND: Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. METHODS: In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). RESULTS: Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. CONCLUSION: The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/28535777/Plasma_phospholipid_fatty_acid_profile_confirms_compliance_to_a_novel_saturated_fat_reduced_monounsaturated_fat_enriched_dairy_product_intervention_in_adults_at_moderate_cardiovascular_risk:_a_randomized_controlled_trial_ L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-017-0249-2 DB - PRIME DP - Unbound Medicine ER -