Tags

Type your tag names separated by a space and hit enter

Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up.
J Nutr Health Aging. 2017; 21(6):681-685.JN

Abstract

OBJECTIVE

Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance.

DESIGN

Single-arm Interventional Human Study.

PARTICIPANTS

23 female subjects (Body Mass Index (BMI) 29-39, aged between 28-42years).

SETTING

Follow-up is designed as 12 months of CR, after which there was a month of IF and 11 months of CR again, to be totally 24 months. Subjects' daily diets were aligned as low calorie diet during CR and during the IF period, the same subjects fasted for 15 hours in a day for a month and there was no daily calorie restriction. Nutritional pattern was changed as 1 meal in the evening and a late supper before sleeping and no eating and drinking during the day light hours in the IF model. Subjects made brisk walking twice a day during the whole follow-up including both CR and IF periods. BMI, Blood glucose, insulin, TSH, GH, HbA1c, IGF-1, Homa-IR and urinary acetoacetate levels were monitored once in three months and twice in the fasting month.

MEASUREMENTS AND RESULTS

While subjects lost 1250 ± 372g monthly during the CR, in the IF period, weight loss was decreased to 473 ± 146 g. BMI of all subjects decreased gradually and as the BMI decreased, glucose, HbA1c, insulin, Homa-IR and TSH levels were decreased. GH levels were at baseline at the beginning, increased in the first six months and stayed steady during the CR and IF period than began decreasing after the IF period, while IGF-I increased gradually during the CR period and beginning with the 7th day of IF period, it decreased and kept on decreasing till the end of the follow-up. Urinary acetoacetate levels were higher during the IF period suggesting a constant lipid catabolism.

CONCLUSION

Our results suggest that, CR affects metabolic parameters positively which will help especially pre-diabetic and insulin resistant patients without any pharmacological approach. In addition IF without calorie restriction can enhance health and cellular resistance to disease without losing weight and those effects may be attributed to different signalling pathways and circulating ketones during IF. Changes observed during IF are probably due to the changes in eating and sleeping pattern and thus changes in metabolic rhythm.

Authors+Show Affiliations

Fehime Benli Aksungar, MD, Prof. Acıbadem Labmed Clinical Laboratories, Acıbadem University, İçerenköy Kayışdağı Caddesi, 34752 Ataşehir, Istanbul, Turkey, e-mail: fehime.aksungar@acibadem.edu.tr, Tel: +90 532 172 7854.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

28537332

Citation

Aksungar, F B., et al. "Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: a Two Year Follow-Up." The Journal of Nutrition, Health & Aging, vol. 21, no. 6, 2017, pp. 681-685.
Aksungar FB, Sarıkaya M, Coskun A, et al. Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up. J Nutr Health Aging. 2017;21(6):681-685.
Aksungar, F. B., Sarıkaya, M., Coskun, A., Serteser, M., & Unsal, I. (2017). Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up. The Journal of Nutrition, Health & Aging, 21(6), 681-685. https://doi.org/10.1007/s12603-016-0786-y
Aksungar FB, et al. Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: a Two Year Follow-Up. J Nutr Health Aging. 2017;21(6):681-685. PubMed PMID: 28537332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Intermittent Fasting Versus Caloric Restriction in Obese Subjects: A Two Year Follow-Up. AU - Aksungar,F B, AU - Sarıkaya,M, AU - Coskun,A, AU - Serteser,M, AU - Unsal,I, PY - 2017/5/25/entrez PY - 2017/5/26/pubmed PY - 2017/11/29/medline KW - Fasting KW - calorie restriction KW - insulin resistance KW - intermittent fasting KW - low carbohydrate SP - 681 EP - 685 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 21 IS - 6 N2 - OBJECTIVE: Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance. DESIGN: Single-arm Interventional Human Study. PARTICIPANTS: 23 female subjects (Body Mass Index (BMI) 29-39, aged between 28-42years). SETTING: Follow-up is designed as 12 months of CR, after which there was a month of IF and 11 months of CR again, to be totally 24 months. Subjects' daily diets were aligned as low calorie diet during CR and during the IF period, the same subjects fasted for 15 hours in a day for a month and there was no daily calorie restriction. Nutritional pattern was changed as 1 meal in the evening and a late supper before sleeping and no eating and drinking during the day light hours in the IF model. Subjects made brisk walking twice a day during the whole follow-up including both CR and IF periods. BMI, Blood glucose, insulin, TSH, GH, HbA1c, IGF-1, Homa-IR and urinary acetoacetate levels were monitored once in three months and twice in the fasting month. MEASUREMENTS AND RESULTS: While subjects lost 1250 ± 372g monthly during the CR, in the IF period, weight loss was decreased to 473 ± 146 g. BMI of all subjects decreased gradually and as the BMI decreased, glucose, HbA1c, insulin, Homa-IR and TSH levels were decreased. GH levels were at baseline at the beginning, increased in the first six months and stayed steady during the CR and IF period than began decreasing after the IF period, while IGF-I increased gradually during the CR period and beginning with the 7th day of IF period, it decreased and kept on decreasing till the end of the follow-up. Urinary acetoacetate levels were higher during the IF period suggesting a constant lipid catabolism. CONCLUSION: Our results suggest that, CR affects metabolic parameters positively which will help especially pre-diabetic and insulin resistant patients without any pharmacological approach. In addition IF without calorie restriction can enhance health and cellular resistance to disease without losing weight and those effects may be attributed to different signalling pathways and circulating ketones during IF. Changes observed during IF are probably due to the changes in eating and sleeping pattern and thus changes in metabolic rhythm. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/28537332/Comparison_of_Intermittent_Fasting_Versus_Caloric_Restriction_in_Obese_Subjects:_A_Two_Year_Follow_Up_ L2 - https://doi.org/10.1007/s12603-016-0786-y DB - PRIME DP - Unbound Medicine ER -