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Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials.
Eur J Clin Nutr. 2017 09; 71(9):1033-1039.EJ

Abstract

Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations. A systematic search was performed in several databases including SCOPUS, PubMed-Medline and Google Scholar until 16 June 2016. We used a random-effects model in combination with weight mean difference (WMD) and 95% confidence intervals (CI) for data analysis. Standard methods were used for the assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias. The meta-analysis of seven RCTs (10 treatment arms) showed a significant reduction of circulating CRP levels (WMD: -0.33 mg/l; 95% CI: -0.50 to -0.15; P<0.001) following quercetin supplementation. In the subgroup analysis, a significant reducing effect was observed in trials with ⩾500 mg/day dosage (WMD: -0.34 mg/l; 95% CI: -0.52, -0.16; P⩽0.001) and in those with CRP <3 mg/l (WMD: -0.34 mg/l; 95% CI: -0.51, -0.18; P⩽0.001). In meta-regression, there was no association between changes in CRP concentrations, dose of supplementation and CRP baseline values. Our findings showed a significant effect of quercetin supplementation on the C-reactive protein-especially at doses above 500 mg/day and in patients with CRP <3 mg/l.

Authors+Show Affiliations

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28537580

Citation

Mohammadi-Sartang, M, et al. "Effects of Supplementation With Quercetin On Plasma C-reactive Protein Concentrations: a Systematic Review and Meta-analysis of Randomized Controlled Trials." European Journal of Clinical Nutrition, vol. 71, no. 9, 2017, pp. 1033-1039.
Mohammadi-Sartang M, Mazloom Z, Sherafatmanesh S, et al. Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2017;71(9):1033-1039.
Mohammadi-Sartang, M., Mazloom, Z., Sherafatmanesh, S., Ghorbani, M., & Firoozi, D. (2017). Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. European Journal of Clinical Nutrition, 71(9), 1033-1039. https://doi.org/10.1038/ejcn.2017.55
Mohammadi-Sartang M, et al. Effects of Supplementation With Quercetin On Plasma C-reactive Protein Concentrations: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Eur J Clin Nutr. 2017;71(9):1033-1039. PubMed PMID: 28537580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of supplementation with quercetin on plasma C-reactive protein concentrations: a systematic review and meta-analysis of randomized controlled trials. AU - Mohammadi-Sartang,M, AU - Mazloom,Z, AU - Sherafatmanesh,S, AU - Ghorbani,M, AU - Firoozi,Donya, Y1 - 2017/05/24/ PY - 2016/11/04/received PY - 2017/03/12/revised PY - 2017/03/15/accepted PY - 2017/5/26/pubmed PY - 2018/5/19/medline PY - 2017/5/25/entrez SP - 1033 EP - 1039 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 71 IS - 9 N2 - Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations. A systematic search was performed in several databases including SCOPUS, PubMed-Medline and Google Scholar until 16 June 2016. We used a random-effects model in combination with weight mean difference (WMD) and 95% confidence intervals (CI) for data analysis. Standard methods were used for the assessment of heterogeneity, meta-regression, sensitivity analysis and publication bias. The meta-analysis of seven RCTs (10 treatment arms) showed a significant reduction of circulating CRP levels (WMD: -0.33 mg/l; 95% CI: -0.50 to -0.15; P<0.001) following quercetin supplementation. In the subgroup analysis, a significant reducing effect was observed in trials with ⩾500 mg/day dosage (WMD: -0.34 mg/l; 95% CI: -0.52, -0.16; P⩽0.001) and in those with CRP <3 mg/l (WMD: -0.34 mg/l; 95% CI: -0.51, -0.18; P⩽0.001). In meta-regression, there was no association between changes in CRP concentrations, dose of supplementation and CRP baseline values. Our findings showed a significant effect of quercetin supplementation on the C-reactive protein-especially at doses above 500 mg/day and in patients with CRP <3 mg/l. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/28537580/Effects_of_supplementation_with_quercetin_on_plasma_C_reactive_protein_concentrations:_a_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - http://dx.doi.org/10.1038/ejcn.2017.55 DB - PRIME DP - Unbound Medicine ER -