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Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice.
Pharmacol Biochem Behav. 1988 Oct; 31(2):405-9.PB

Abstract

The role of cholinergic and GABAergic neuronal systems on the cycloheximide (CXM)-induced amnesia was investigated using the step-down-type passive avoidance task in mice. CXM (7.5-120 mg/kg, SC) given just after the training caused amnesia (indicated by short latency to step down from the platform on the grid floor) in the retention test conducted 24 hr later in a dose-dependent fashion. In the CXM (60 mg/kg)-treated mice, a choline esterase inhibitor, physostigmine (PHY; 0.125 and 0.25 mg/kg, IP), or GABA agonists, muscimol (1 and 2 mg/kg, IP) and baclofen (6 and 12 mg/kg, IP), given just after training markedly prolonged step down latency (SDL), indicating reversal of amnesia. The antiamnesic action of PHY (0.125 mg/kg) was almost completely antagonized by a central acetylcholine antagonist, scopolamine (3 mg/kg, SC), but not by a peripheral acetylcholine antagonist, butylscopolamine (3 mg/kg, SC). Furthermore, the antiamnesic action of muscimol (2 mg/kg) was reversed by GABA antagonists, picrotoxin (0.5 mg/kg, SC) and bicuculline (0.5 mg/kg, SC), while the effect of baclofen (12 mg/kg) was reversed by picrotoxin (0.5 mg/kg), but not by bicuculline (0.5 mg/kg). These results suggest that the dysfunction of cholinergic and GABAergic neuronal systems play an important role in the CXM-induced memory impairment on the passive avoidance task.

Authors+Show Affiliations

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2854264

Citation

Nabeshima, T, et al. "Role of Cholinergic and GABAergic Neuronal Systems in Cycloheximide-induced Amnesia in Mice." Pharmacology, Biochemistry, and Behavior, vol. 31, no. 2, 1988, pp. 405-9.
Nabeshima T, Noda Y, Itoh K, et al. Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice. Pharmacol Biochem Behav. 1988;31(2):405-9.
Nabeshima, T., Noda, Y., Itoh, K., & Kameyama, T. (1988). Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice. Pharmacology, Biochemistry, and Behavior, 31(2), 405-9.
Nabeshima T, et al. Role of Cholinergic and GABAergic Neuronal Systems in Cycloheximide-induced Amnesia in Mice. Pharmacol Biochem Behav. 1988;31(2):405-9. PubMed PMID: 2854264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice. AU - Nabeshima,T, AU - Noda,Y, AU - Itoh,K, AU - Kameyama,T, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 405 EP - 9 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 31 IS - 2 N2 - The role of cholinergic and GABAergic neuronal systems on the cycloheximide (CXM)-induced amnesia was investigated using the step-down-type passive avoidance task in mice. CXM (7.5-120 mg/kg, SC) given just after the training caused amnesia (indicated by short latency to step down from the platform on the grid floor) in the retention test conducted 24 hr later in a dose-dependent fashion. In the CXM (60 mg/kg)-treated mice, a choline esterase inhibitor, physostigmine (PHY; 0.125 and 0.25 mg/kg, IP), or GABA agonists, muscimol (1 and 2 mg/kg, IP) and baclofen (6 and 12 mg/kg, IP), given just after training markedly prolonged step down latency (SDL), indicating reversal of amnesia. The antiamnesic action of PHY (0.125 mg/kg) was almost completely antagonized by a central acetylcholine antagonist, scopolamine (3 mg/kg, SC), but not by a peripheral acetylcholine antagonist, butylscopolamine (3 mg/kg, SC). Furthermore, the antiamnesic action of muscimol (2 mg/kg) was reversed by GABA antagonists, picrotoxin (0.5 mg/kg, SC) and bicuculline (0.5 mg/kg, SC), while the effect of baclofen (12 mg/kg) was reversed by picrotoxin (0.5 mg/kg), but not by bicuculline (0.5 mg/kg). These results suggest that the dysfunction of cholinergic and GABAergic neuronal systems play an important role in the CXM-induced memory impairment on the passive avoidance task. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/2854264/Role_of_cholinergic_and_GABAergic_neuronal_systems_in_cycloheximide_induced_amnesia_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(88)90366-8 DB - PRIME DP - Unbound Medicine ER -