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Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors.
Drug Test Anal. 2018 Feb; 10(2):372-378.DT

Abstract

Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them. By using complementary analytical techniques (i.e. one- and two-dimensional NMR, FT-IR, GC-MS, HRMS and HPLC-UV), this study investigates the detection, identification and full characterization of 1-(4-methylphenyl)-2-(methylamino)pentanone (4-methylpentedrone, 4-MPD), 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)hexanone (4F-PHP) and 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (bk-EPDP), three emerging cathinone derivatives.

Authors+Show Affiliations

Analytical & Environmental Sciences Division, King's College London, London, UK.TICTAC Communications Ltd, Room 1.159 Jenner Wing, St George's University of London, London, UK.TICTAC Communications Ltd, Room 1.159 Jenner Wing, St George's University of London, London, UK.Analytical & Environmental Sciences Division, King's College London, London, UK. Drug Control Centre, King's College London, London, UK.Institute of Pharmaceutical Science, King's College London, London, UK.Analytical & Environmental Sciences Division, King's College London, London, UK.Drug Control Centre, King's College London, London, UK. Institute of Pharmaceutical Science, King's College London, London, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28544816

Citation

Apirakkan, Orapan, et al. "Analytical Characterization of Three Cathinone Derivatives, 4-MPD, 4F-PHP and bk-EPDP, Purchased as Bulk Powder From Online Vendors." Drug Testing and Analysis, vol. 10, no. 2, 2018, pp. 372-378.
Apirakkan O, Frinculescu A, Shine T, et al. Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors. Drug Test Anal. 2018;10(2):372-378.
Apirakkan, O., Frinculescu, A., Shine, T., Parkin, M. C., Cilibrizzi, A., Frascione, N., & Abbate, V. (2018). Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors. Drug Testing and Analysis, 10(2), 372-378. https://doi.org/10.1002/dta.2218
Apirakkan O, et al. Analytical Characterization of Three Cathinone Derivatives, 4-MPD, 4F-PHP and bk-EPDP, Purchased as Bulk Powder From Online Vendors. Drug Test Anal. 2018;10(2):372-378. PubMed PMID: 28544816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors. AU - Apirakkan,Orapan, AU - Frinculescu,Anca, AU - Shine,Trevor, AU - Parkin,Mark C, AU - Cilibrizzi,Agostino, AU - Frascione,Nunzianda, AU - Abbate,Vincenzo, Y1 - 2017/07/18/ PY - 2017/01/30/received PY - 2017/05/17/revised PY - 2017/05/18/accepted PY - 2017/5/26/pubmed PY - 2018/9/19/medline PY - 2017/5/26/entrez KW - 4-MPD KW - 4F-PHP KW - bk-EPDP KW - new psychoactive substances KW - synthetic cathinones SP - 372 EP - 378 JF - Drug testing and analysis JO - Drug Test Anal VL - 10 IS - 2 N2 - Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them. By using complementary analytical techniques (i.e. one- and two-dimensional NMR, FT-IR, GC-MS, HRMS and HPLC-UV), this study investigates the detection, identification and full characterization of 1-(4-methylphenyl)-2-(methylamino)pentanone (4-methylpentedrone, 4-MPD), 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)hexanone (4F-PHP) and 1-(1,3-benzodioxol-5-yl)-2-(ethylamino)-1-pentanone (bk-EPDP), three emerging cathinone derivatives. SN - 1942-7611 UR - https://www.unboundmedicine.com/medline/citation/28544816/Analytical_characterization_of_three_cathinone_derivatives_4_MPD_4F_PHP_and_bk_EPDP_purchased_as_bulk_powder_from_online_vendors_ L2 - https://doi.org/10.1002/dta.2218 DB - PRIME DP - Unbound Medicine ER -