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Association of infiltrating cells with microvessel density in oral squamous cell carcinoma.
Pol J Pathol. 2017; 68(1):40-48.PJ

Abstract

Several lines of evidence indicate that immune cells in the tumor microenvironment play an important role in regulating tumor progression. An immunohistochemical method was used to examine the abundance of natural killer (NK) cells, mucosal dendritic cells (DCs), macrophages, mast cells, and microvessel density in 78 cases of oral squamous cell carcinoma (OSCC): with better prognosis - OSCCBP (n = 37), and with poorer prognosis - OSCCPP (n = 41), and 18 controls. The mean numbers of macrophages and microvessels were significantly higher in the OSCCPP group in comparison to both OSCCBP and control groups. The mean number of NK cells, mast cells and DCs was lower in the OSCCPP group in comparison to the OSCCBP group, but there were no statistically significant differences between mean numbers of NK cells in tested groups. Statistically significant correlations between the number of DCs and NK cells and mast cells, as well as between microvessel density and numbers of macrophages, DCs and mast cells were revealed in both OSCCPP and OSCCBP groups. In conclusion, our findings revealed an association between the number of infiltrating cells and oral cancer prognosis. Moreover, our results suggest that the infiltrating cells (macrophages, Langerhans and mast cells) may be involved in the process of angiogenesis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28547979

Citation

Stasikowska-Kanicka, Olga, et al. "Association of Infiltrating Cells With Microvessel Density in Oral Squamous Cell Carcinoma." Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, vol. 68, no. 1, 2017, pp. 40-48.
Stasikowska-Kanicka O, Wągrowska-Danilewicz M, Danilewicz M. Association of infiltrating cells with microvessel density in oral squamous cell carcinoma. Pol J Pathol. 2017;68(1):40-48.
Stasikowska-Kanicka, O., Wągrowska-Danilewicz, M., & Danilewicz, M. (2017). Association of infiltrating cells with microvessel density in oral squamous cell carcinoma. Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists, 68(1), 40-48. https://doi.org/10.5114/pjp.2017.67614
Stasikowska-Kanicka O, Wągrowska-Danilewicz M, Danilewicz M. Association of Infiltrating Cells With Microvessel Density in Oral Squamous Cell Carcinoma. Pol J Pathol. 2017;68(1):40-48. PubMed PMID: 28547979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of infiltrating cells with microvessel density in oral squamous cell carcinoma. AU - Stasikowska-Kanicka,Olga, AU - Wągrowska-Danilewicz,Małgorzata, AU - Danilewicz,Marian, PY - 2017/5/27/entrez PY - 2017/5/27/pubmed PY - 2017/7/27/medline KW - dendritic cells KW - macrophages KW - mast cells KW - natural killers KW - tumor microenvironment KW - oral cancer SP - 40 EP - 48 JF - Polish journal of pathology : official journal of the Polish Society of Pathologists JO - Pol J Pathol VL - 68 IS - 1 N2 - Several lines of evidence indicate that immune cells in the tumor microenvironment play an important role in regulating tumor progression. An immunohistochemical method was used to examine the abundance of natural killer (NK) cells, mucosal dendritic cells (DCs), macrophages, mast cells, and microvessel density in 78 cases of oral squamous cell carcinoma (OSCC): with better prognosis - OSCCBP (n = 37), and with poorer prognosis - OSCCPP (n = 41), and 18 controls. The mean numbers of macrophages and microvessels were significantly higher in the OSCCPP group in comparison to both OSCCBP and control groups. The mean number of NK cells, mast cells and DCs was lower in the OSCCPP group in comparison to the OSCCBP group, but there were no statistically significant differences between mean numbers of NK cells in tested groups. Statistically significant correlations between the number of DCs and NK cells and mast cells, as well as between microvessel density and numbers of macrophages, DCs and mast cells were revealed in both OSCCPP and OSCCBP groups. In conclusion, our findings revealed an association between the number of infiltrating cells and oral cancer prognosis. Moreover, our results suggest that the infiltrating cells (macrophages, Langerhans and mast cells) may be involved in the process of angiogenesis. SN - 1233-9687 UR - https://www.unboundmedicine.com/medline/citation/28547979/Association_of_infiltrating_cells_with_microvessel_density_in_oral_squamous_cell_carcinoma_ L2 - http://www.pjp.termedia.pl/showarticle.php?id=29899 DB - PRIME DP - Unbound Medicine ER -