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Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes.
Virchows Arch 2017; 471(1):65-76VA

Abstract

Intraductal papillary epithelial neoplasms of the pancreatobiliary system (intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN)) seem to share many clinicopathological features; however, IPNB has not been fully characterized. In order to understand the clinicopathological/immunohistochemical features of IPNB better, we compared 52 cases of IPNB with 42 cases of IPMNs with mural nodules. The IPNB cases were divided into two groups according to their histological similarity and according to five key histological findings. All IPNB and IPMN cases mainly affected middle-aged to elderly people, predominantly men. Mucin hypersecretion was less frequent in IPNB compared to IPMN. Group 2 IPNB more frequently had a higher histopathological grade and more extensive stromal invasion than IPMN. Group 1 IPNB and IPMN were further classified into four subtypes (gastric, intestinal, pancreatobiliary, and oncocytic). Although each subtype of IPNB and IPMN showed similar histology, the immunohistochemical results were different. The gastric type of IPNB was less frequently positive for CDX2, and intestinal IPNB was more frequently positive for MUC1 and less frequently positive for MUC2, MUC5AC, and CDX2 compared to each subtype of IPMN, respectively. In conclusion, IPNB and IPMN have some clinicopathological features in common, but mucin hypersecretion was less frequent both in IPNBs than in IPMN. Group 2 IPNB differed from IPMN in several parameters of tumor aggressiveness. Additional clinicopathological and molecular studies should be performed with respect to the subtypes of IPNB and IPMN.

Authors+Show Affiliations

Department of Human Pathology, School of Medicine, Juntendo University, Hongo 2-1-1, Tokyo, 113-8421, Japan. yfuku@juntendo.ac.jp.Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.Department of Diagnostic Pathology, Shizuoka Cancer Center, Shizuoka, Japan.Department of Clinical Laboratory, Koshigaya Municipal Hospital, Saitama, Japan.Department of Human Pathology, School of Medicine, Juntendo University, Hongo 2-1-1, Tokyo, 113-8421, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28550497

Citation

Fukumura, Yuki, et al. "Clinicopathological Features of Intraductal Papillary Neoplasms of the Bile Duct: a Comparison With Intraductal Papillary Mucinous Neoplasm of the Pancreas With Reference to Subtypes." Virchows Archiv : an International Journal of Pathology, vol. 471, no. 1, 2017, pp. 65-76.
Fukumura Y, Nakanuma Y, Kakuda Y, et al. Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes. Virchows Arch. 2017;471(1):65-76.
Fukumura, Y., Nakanuma, Y., Kakuda, Y., Takase, M., & Yao, T. (2017). Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes. Virchows Archiv : an International Journal of Pathology, 471(1), pp. 65-76. doi:10.1007/s00428-017-2144-9.
Fukumura Y, et al. Clinicopathological Features of Intraductal Papillary Neoplasms of the Bile Duct: a Comparison With Intraductal Papillary Mucinous Neoplasm of the Pancreas With Reference to Subtypes. Virchows Arch. 2017;471(1):65-76. PubMed PMID: 28550497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological features of intraductal papillary neoplasms of the bile duct: a comparison with intraductal papillary mucinous neoplasm of the pancreas with reference to subtypes. AU - Fukumura,Yuki, AU - Nakanuma,Yasuni, AU - Kakuda,Yuko, AU - Takase,Masaru, AU - Yao,Takashi, Y1 - 2017/05/26/ PY - 2016/02/18/received PY - 2017/05/04/accepted PY - 2017/03/30/revised PY - 2017/5/28/pubmed PY - 2017/9/19/medline PY - 2017/5/28/entrez KW - Intraductal papillary neoplasm KW - Mucin secretion KW - Mucus core protein KW - Pancreatobiliary system SP - 65 EP - 76 JF - Virchows Archiv : an international journal of pathology JO - Virchows Arch. VL - 471 IS - 1 N2 - Intraductal papillary epithelial neoplasms of the pancreatobiliary system (intraductal papillary neoplasm of the bile duct (IPNB) and intraductal papillary mucinous neoplasm (IPMN)) seem to share many clinicopathological features; however, IPNB has not been fully characterized. In order to understand the clinicopathological/immunohistochemical features of IPNB better, we compared 52 cases of IPNB with 42 cases of IPMNs with mural nodules. The IPNB cases were divided into two groups according to their histological similarity and according to five key histological findings. All IPNB and IPMN cases mainly affected middle-aged to elderly people, predominantly men. Mucin hypersecretion was less frequent in IPNB compared to IPMN. Group 2 IPNB more frequently had a higher histopathological grade and more extensive stromal invasion than IPMN. Group 1 IPNB and IPMN were further classified into four subtypes (gastric, intestinal, pancreatobiliary, and oncocytic). Although each subtype of IPNB and IPMN showed similar histology, the immunohistochemical results were different. The gastric type of IPNB was less frequently positive for CDX2, and intestinal IPNB was more frequently positive for MUC1 and less frequently positive for MUC2, MUC5AC, and CDX2 compared to each subtype of IPMN, respectively. In conclusion, IPNB and IPMN have some clinicopathological features in common, but mucin hypersecretion was less frequent both in IPNBs than in IPMN. Group 2 IPNB differed from IPMN in several parameters of tumor aggressiveness. Additional clinicopathological and molecular studies should be performed with respect to the subtypes of IPNB and IPMN. SN - 1432-2307 UR - https://www.unboundmedicine.com/medline/citation/28550497/Clinicopathological_features_of_intraductal_papillary_neoplasms_of_the_bile_duct:_a_comparison_with_intraductal_papillary_mucinous_neoplasm_of_the_pancreas_with_reference_to_subtypes_ L2 - https://dx.doi.org/10.1007/s00428-017-2144-9 DB - PRIME DP - Unbound Medicine ER -