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Increased incidence of prolonged ileus after colectomy for inflammatory bowel diseases under ERAS protocol: a cohort analysis.
J Surg Res 2017; 212:86-93JS

Abstract

BACKGROUND

Postoperative ileus is a common problem after colorectal surgery. The aim of the study was to investigate the incidence and risk factors for prolonged postoperative ileus (POI) after colectomy for inflammatory bowel diseases (IBDs).

METHODS

Consecutive patients who underwent colorectal resection for IBD versus colorectal cancer (CRC) patients under enhanced recovery after surgery protocol were retrospectively analyzed. Primary assessment end point is the incidence of prolonged POI (>4 days); secondary end points were GI-2 recovery (time to first toleration of solid food and first bowel movement), nasogastric tube reinsertion, and postoperative length of stay. Risk factors for prolonged POI in IBD patients were assessed by multiple logistic regression analysis with P score matching.

RESULTS

The incidence of prolonged POI was higher in IBD versus CRC group (28.8% versus 14.8%, P < 0.001). Patients with IBD had a longer time to GI-2 recovery (4.8 ± 2.1 versus 3.7 ± 1.4 d, P < 0.001), postoperative length of stay (10.7 ± 6.2 versus 7.9 ± 5.3 d, P < 0.001), higher incidence of nasogastric tube reinsertion (9.8% versus 4.0%, P = 0.02). After propensity-score matching analysis, the differences were still significant. Preoperative steroid use >20 mg/d (odds ratio, [OR] = 2.19, P = 0.048), hypoalbuminemia (<35 g/L; OR 2.72, P = 0.03), systemic inflammatory response syndrome status (OR 4.91, P = 0.03), and postoperative intraabdominal sepsis (OR 9.31, P = 0.001) were independent risk factors for prolonged POI in IBD patients.

CONCLUSIONS

In the setting of enhanced recovery after surgery, colectomy for IBD is associated with delayed gastrointestinal function recovery and higher incidence of prolonged POI compared to CRC patients. Normalizing preoperative albumin level, weaning off steroids, reducing preoperative systemic inflammatory response syndrome, and early management of postoperative intraabdominal sepsis may reduce POI in IBD population.

Authors+Show Affiliations

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of General Surgery, Jinling Hospital Affiliated to Southern Medical University, Nanjing, China.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Department of General Surgery, Jinling Hospital Affiliated to Southern Medical University, Nanjing, China. Electronic address: gongjianfeng@aliyun.com.Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28550927

Citation

Dai, Xujie, et al. "Increased Incidence of Prolonged Ileus After Colectomy for Inflammatory Bowel Diseases Under ERAS Protocol: a Cohort Analysis." The Journal of Surgical Research, vol. 212, 2017, pp. 86-93.
Dai X, Ge X, Yang J, et al. Increased incidence of prolonged ileus after colectomy for inflammatory bowel diseases under ERAS protocol: a cohort analysis. J Surg Res. 2017;212:86-93.
Dai, X., Ge, X., Yang, J., Zhang, T., Xie, T., Gao, W., ... Zhu, W. (2017). Increased incidence of prolonged ileus after colectomy for inflammatory bowel diseases under ERAS protocol: a cohort analysis. The Journal of Surgical Research, 212, pp. 86-93. doi:10.1016/j.jss.2016.12.031.
Dai X, et al. Increased Incidence of Prolonged Ileus After Colectomy for Inflammatory Bowel Diseases Under ERAS Protocol: a Cohort Analysis. J Surg Res. 2017 05 15;212:86-93. PubMed PMID: 28550927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased incidence of prolonged ileus after colectomy for inflammatory bowel diseases under ERAS protocol: a cohort analysis. AU - Dai,Xujie, AU - Ge,Xiaolong, AU - Yang,Jianbo, AU - Zhang,Tenghui, AU - Xie,Tingbin, AU - Gao,Wen, AU - Gong,Jianfeng, AU - Zhu,Weiming, Y1 - 2016/12/29/ PY - 2016/10/26/received PY - 2016/12/13/revised PY - 2016/12/22/accepted PY - 2017/5/29/entrez PY - 2017/5/30/pubmed PY - 2017/9/14/medline KW - Colorectal cancer KW - Colorectal surgery KW - Enhanced recovery after surgery KW - Inflammatory bowel diseases KW - Postoperative ileus SP - 86 EP - 93 JF - The Journal of surgical research JO - J. Surg. Res. VL - 212 N2 - BACKGROUND: Postoperative ileus is a common problem after colorectal surgery. The aim of the study was to investigate the incidence and risk factors for prolonged postoperative ileus (POI) after colectomy for inflammatory bowel diseases (IBDs). METHODS: Consecutive patients who underwent colorectal resection for IBD versus colorectal cancer (CRC) patients under enhanced recovery after surgery protocol were retrospectively analyzed. Primary assessment end point is the incidence of prolonged POI (>4 days); secondary end points were GI-2 recovery (time to first toleration of solid food and first bowel movement), nasogastric tube reinsertion, and postoperative length of stay. Risk factors for prolonged POI in IBD patients were assessed by multiple logistic regression analysis with P score matching. RESULTS: The incidence of prolonged POI was higher in IBD versus CRC group (28.8% versus 14.8%, P < 0.001). Patients with IBD had a longer time to GI-2 recovery (4.8 ± 2.1 versus 3.7 ± 1.4 d, P < 0.001), postoperative length of stay (10.7 ± 6.2 versus 7.9 ± 5.3 d, P < 0.001), higher incidence of nasogastric tube reinsertion (9.8% versus 4.0%, P = 0.02). After propensity-score matching analysis, the differences were still significant. Preoperative steroid use >20 mg/d (odds ratio, [OR] = 2.19, P = 0.048), hypoalbuminemia (<35 g/L; OR 2.72, P = 0.03), systemic inflammatory response syndrome status (OR 4.91, P = 0.03), and postoperative intraabdominal sepsis (OR 9.31, P = 0.001) were independent risk factors for prolonged POI in IBD patients. CONCLUSIONS: In the setting of enhanced recovery after surgery, colectomy for IBD is associated with delayed gastrointestinal function recovery and higher incidence of prolonged POI compared to CRC patients. Normalizing preoperative albumin level, weaning off steroids, reducing preoperative systemic inflammatory response syndrome, and early management of postoperative intraabdominal sepsis may reduce POI in IBD population. SN - 1095-8673 UR - https://www.unboundmedicine.com/medline/citation/28550927/Increased_incidence_of_prolonged_ileus_after_colectomy_for_inflammatory_bowel_diseases_under_ERAS_protocol:_a_cohort_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-4804(16)30581-9 DB - PRIME DP - Unbound Medicine ER -