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Effects of Coating Materials and Processing Conditions on Flow Enhancement of Cohesive Acetaminophen Powders by High-Shear Processing With Pharmaceutical Lubricants.
J Pharm Sci. 2017 10; 106(10):3022-3032.JP

Abstract

This study has investigated the surface coating efficiency and powder flow improvement of a model cohesive acetaminophen powder by high-shear processing with pharmaceutical lubricants through 2 common equipment, conical comil and high-shear mixer. Effects of coating materials and processing parameters on powder flow and surface coating coverage were evaluated. Both Carr's index and shear cell data indicated that processing with the lubricants using comil or high-shear mixer substantially improved the flow of the cohesive acetaminophen powder. Flow improvement was most pronounced for those processed with 1% wt/wt magnesium stearate, from "cohesive" for the V-blended sample to "easy flowing" for the optimally coated sample. Qualitative and quantitative characterizations demonstrated a greater degree of surface coverage for high-shear mixing compared with comilling; nevertheless, flow properties of the samples at the corresponding optimized conditions were comparable between 2 techniques. Scanning electron microscopy images demonstrated different coating mechanisms with magnesium stearate or l-leucine (magnesium stearate forms a coating layer and leucine coating increases surface roughness). Furthermore, surface coating with hydrophobic magnesium stearate did not retard the dissolution kinetics of acetaminophen. Future studies are warranted to evaluate tableting behavior of such dry-coated pharmaceutical powders.

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Authors+Show Affiliations

Wei G
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091; Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning, China.
Mangal S
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091.
Denman J
Future Industries Institute, University of South Australia, Mawson Lakes, South Australia, Australia.
Gengenbach T
CSIRO Manufacturing, Bayview Avenue, Clayton, Victoria, Australia.
Lee Bonar K
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091.
Khan RI
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091.
Qu L
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Li T
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091.
Zhou QT
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907-2091. Electronic address: tonyzhou@purdue.edu.

MeSH

AcetaminophenChemistry, PharmaceuticalDrug CompoundingExcipientsHydrophobic and Hydrophilic InteractionsKineticsLeucineLubricantsPowdersStearic AcidsSurface PropertiesTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28551425

Citation

Wei, Guoguang, et al. "Effects of Coating Materials and Processing Conditions On Flow Enhancement of Cohesive Acetaminophen Powders By High-Shear Processing With Pharmaceutical Lubricants." Journal of Pharmaceutical Sciences, vol. 106, no. 10, 2017, pp. 3022-3032.
Wei G, Mangal S, Denman J, et al. Effects of Coating Materials and Processing Conditions on Flow Enhancement of Cohesive Acetaminophen Powders by High-Shear Processing With Pharmaceutical Lubricants. J Pharm Sci. 2017;106(10):3022-3032.
Wei, G., Mangal, S., Denman, J., Gengenbach, T., Lee Bonar, K., Khan, R. I., Qu, L., Li, T., & Zhou, Q. T. (2017). Effects of Coating Materials and Processing Conditions on Flow Enhancement of Cohesive Acetaminophen Powders by High-Shear Processing With Pharmaceutical Lubricants. Journal of Pharmaceutical Sciences, 106(10), 3022-3032. https://doi.org/10.1016/j.xphs.2017.05.020
Wei G, et al. Effects of Coating Materials and Processing Conditions On Flow Enhancement of Cohesive Acetaminophen Powders By High-Shear Processing With Pharmaceutical Lubricants. J Pharm Sci. 2017;106(10):3022-3032. PubMed PMID: 28551425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Coating Materials and Processing Conditions on Flow Enhancement of Cohesive Acetaminophen Powders by High-Shear Processing With Pharmaceutical Lubricants. AU - Wei,Guoguang, AU - Mangal,Sharad, AU - Denman,John, AU - Gengenbach,Thomas, AU - Lee Bonar,Kevin, AU - Khan,Rubayat I, AU - Qu,Li, AU - Li,Tonglei, AU - Zhou,Qi Tony, Y1 - 2017/05/24/ PY - 2017/03/01/received PY - 2017/04/20/revised PY - 2017/05/04/accepted PY - 2017/5/30/pubmed PY - 2018/5/15/medline PY - 2017/5/29/entrez KW - comil KW - dissolution KW - high-shear mix KW - powder flow KW - surface coating SP - 3022 EP - 3032 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 106 IS - 10 N2 - This study has investigated the surface coating efficiency and powder flow improvement of a model cohesive acetaminophen powder by high-shear processing with pharmaceutical lubricants through 2 common equipment, conical comil and high-shear mixer. Effects of coating materials and processing parameters on powder flow and surface coating coverage were evaluated. Both Carr's index and shear cell data indicated that processing with the lubricants using comil or high-shear mixer substantially improved the flow of the cohesive acetaminophen powder. Flow improvement was most pronounced for those processed with 1% wt/wt magnesium stearate, from "cohesive" for the V-blended sample to "easy flowing" for the optimally coated sample. Qualitative and quantitative characterizations demonstrated a greater degree of surface coverage for high-shear mixing compared with comilling; nevertheless, flow properties of the samples at the corresponding optimized conditions were comparable between 2 techniques. Scanning electron microscopy images demonstrated different coating mechanisms with magnesium stearate or l-leucine (magnesium stearate forms a coating layer and leucine coating increases surface roughness). Furthermore, surface coating with hydrophobic magnesium stearate did not retard the dissolution kinetics of acetaminophen. Future studies are warranted to evaluate tableting behavior of such dry-coated pharmaceutical powders. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/28551425/Effects_of_Coating_Materials_and_Processing_Conditions_on_Flow_Enhancement_of_Cohesive_Acetaminophen_Powders_by_High_Shear_Processing_With_Pharmaceutical_Lubricants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3549(17)30374-X DB - PRIME DP - Unbound Medicine ER -