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Microneedle Patches as Drug and Vaccine Delivery Platform.
Curr Med Chem 2017; 24(22):2413-2422CM

Abstract

BACKGROUND

Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery.

METHODS

We reviewed the most of recently published papers on microneedle patches, summarized their evolution, classification, state-of the-art capabilities and discussed promising application in drugs and vaccine delivery.

RESULTS

With the rapid development of nanotechnology, microneedle patches have been improved by switching from undissolving to dissolving microneedles, and their safety has also improved dramatically. As a drug delivery tool, microneedle patches can deliver bioactive molecular of different physical size. Additionally, microneedle patches can be coated or encapsulate with DNA vaccine, subunit antigen, inactivated or live virus vaccine. Combining clinical results with the results of patient interview, microneedle patches are found to be feasible and are predicated to soon be acceptable for the medical service.

CONCLUSION

In this review, we summarized the evolution, current and future application of microneedle patches as delivery vehicle for drugs and vaccines. Compared with traditional delivery tools, microneedle patches have many advantages, such as providing pain-free, non-invasive, convenient route for reagent administration and delivery, with no cold chain required for storage and transportation as well as decreasing sharp medical waste, needle-caused injury and transmission of blood-borne infectious disease in rural area. However, even though there are dramatic progress in preclinical investigation of microneedle patches, further testing will be required for clinical application. Further research should be implemented in multiple fields, such as vaccinology, immunology, and materials science, to improve this delivery platform. Because of their advantages in dose sparing, safety and treatment compliance, microneedle patches are expected to be widely applied in clinical treatment and vaccine administration in near future.

Authors+Show Affiliations

College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China.Center of Emphasis in Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905-2827, United States.College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China.Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan University, Changsha, 410082, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28552053

Citation

Li, Junwei, et al. "Microneedle Patches as Drug and Vaccine Delivery Platform." Current Medicinal Chemistry, vol. 24, no. 22, 2017, pp. 2413-2422.
Li J, Zeng M, Shan H, et al. Microneedle Patches as Drug and Vaccine Delivery Platform. Curr Med Chem. 2017;24(22):2413-2422.
Li, J., Zeng, M., Shan, H., & Tong, C. (2017). Microneedle Patches as Drug and Vaccine Delivery Platform. Current Medicinal Chemistry, 24(22), pp. 2413-2422. doi:10.2174/0929867324666170526124053.
Li J, et al. Microneedle Patches as Drug and Vaccine Delivery Platform. Curr Med Chem. 2017;24(22):2413-2422. PubMed PMID: 28552053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microneedle Patches as Drug and Vaccine Delivery Platform. AU - Li,Junwei, AU - Zeng,Mingtao, AU - Shan,Hu, AU - Tong,Chunyi, PY - 2017/01/25/received PY - 2017/05/10/revised PY - 1970/01/01/accepted PY - 2017/5/30/pubmed PY - 2017/9/13/medline PY - 2017/5/30/entrez KW - Microneedle patches KW - dissolving microneedles KW - drug deliver KW - transcutoneous delivery KW - vaccine SP - 2413 EP - 2422 JF - Current medicinal chemistry JO - Curr. Med. Chem. VL - 24 IS - 22 N2 - BACKGROUND: Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery. METHODS: We reviewed the most of recently published papers on microneedle patches, summarized their evolution, classification, state-of the-art capabilities and discussed promising application in drugs and vaccine delivery. RESULTS: With the rapid development of nanotechnology, microneedle patches have been improved by switching from undissolving to dissolving microneedles, and their safety has also improved dramatically. As a drug delivery tool, microneedle patches can deliver bioactive molecular of different physical size. Additionally, microneedle patches can be coated or encapsulate with DNA vaccine, subunit antigen, inactivated or live virus vaccine. Combining clinical results with the results of patient interview, microneedle patches are found to be feasible and are predicated to soon be acceptable for the medical service. CONCLUSION: In this review, we summarized the evolution, current and future application of microneedle patches as delivery vehicle for drugs and vaccines. Compared with traditional delivery tools, microneedle patches have many advantages, such as providing pain-free, non-invasive, convenient route for reagent administration and delivery, with no cold chain required for storage and transportation as well as decreasing sharp medical waste, needle-caused injury and transmission of blood-borne infectious disease in rural area. However, even though there are dramatic progress in preclinical investigation of microneedle patches, further testing will be required for clinical application. Further research should be implemented in multiple fields, such as vaccinology, immunology, and materials science, to improve this delivery platform. Because of their advantages in dose sparing, safety and treatment compliance, microneedle patches are expected to be widely applied in clinical treatment and vaccine administration in near future. SN - 1875-533X UR - https://www.unboundmedicine.com/medline/citation/28552053/Microneedle_Patches_as_Drug_and_Vaccine_Delivery_Platform_ L2 - http://www.eurekaselect.com/152718/article DB - PRIME DP - Unbound Medicine ER -