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Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study.
Int J Chron Obstruct Pulmon Dis. 2017; 12:1415-1425.IJ

Abstract

BACKGROUND

The aim of this study was to evaluate the efficiency of a simple prototype device for training respiratory muscles in lung function, respiratory muscle strength, walking capacity, quality of life (QOL), dyspnea, and oxidative stress in patients with COPD.

METHODS

Thirty COPD patients with moderate severity of the disease were randomized into three groups: control (n=10, 6 males and 4 females), standard training (n=10, 4 males and 6 females), and prototype device (n=10, 5 males and 5 females). Respiratory muscle strength (maximal inspiratory pressure [PImax] and maximal expiratory pressure [PEmax]), lung function (forced vital capacity [FVC], percentage of FVC, forced expiratory volume in 1 second [FEV1], percentage of FEV1 [FEV1%], and FEV1/FVC), 6-minute walking distance (6MWD), QOL, and oxidative stress markers (total antioxidant capacity [TAC]), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were evaluated before and after 6 weeks of training. Moreover, dyspnea scores were assessed before; during week 2, 4, and 6 of training; and at rest after training.

RESULTS

All parameters between the groups had no statistical difference before training, and no statistical change in the control group after week 6. FVC, FEV1/FVC, PImax, PEmax, QOL, MDA, and NO showed significant changes after 6 weeks of training with either the standard or prototype device, compared to pre-training. FEV1, FEV1%, 6MWD, TAC, and GSH data did not change statistically. Furthermore, the results of significant changes in all parameters were not statistically different between training groups using the standard and prototype device. The peak dyspnea scores increased significantly in week 4 and 6 when applying the standard or prototype device, and then lowered significantly at rest after 6 weeks of training, compared to pre-training.

CONCLUSION

This study proposes that a simple prototype device can be used clinically in COPD patients as a standard device to train respiratory muscles, improving lung function and QOL, as well as involving MDA and NO levels.

Authors+Show Affiliations

Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai.Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai.Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen.Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28553094

Citation

Leelarungrayub, Jirakrit, et al. "Effects of a Simple Prototype Respiratory Muscle Trainer On Respiratory Muscle Strength, Quality of Life and Dyspnea, and Oxidative Stress in COPD Patients: a Preliminary Study." International Journal of Chronic Obstructive Pulmonary Disease, vol. 12, 2017, pp. 1415-1425.
Leelarungrayub J, Pinkaew D, Puntumetakul R, et al. Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study. Int J Chron Obstruct Pulmon Dis. 2017;12:1415-1425.
Leelarungrayub, J., Pinkaew, D., Puntumetakul, R., & Klaphajone, J. (2017). Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study. International Journal of Chronic Obstructive Pulmonary Disease, 12, 1415-1425. https://doi.org/10.2147/COPD.S131062
Leelarungrayub J, et al. Effects of a Simple Prototype Respiratory Muscle Trainer On Respiratory Muscle Strength, Quality of Life and Dyspnea, and Oxidative Stress in COPD Patients: a Preliminary Study. Int J Chron Obstruct Pulmon Dis. 2017;12:1415-1425. PubMed PMID: 28553094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a simple prototype respiratory muscle trainer on respiratory muscle strength, quality of life and dyspnea, and oxidative stress in COPD patients: a preliminary study. AU - Leelarungrayub,Jirakrit, AU - Pinkaew,Decha, AU - Puntumetakul,Rungthip, AU - Klaphajone,Jakkrit, Y1 - 2017/05/12/ PY - 2017/5/30/entrez PY - 2017/5/30/pubmed PY - 2018/3/20/medline KW - COPD KW - PImax KW - lung function KW - oxidative stress KW - prototype simple training device KW - quality of life SP - 1415 EP - 1425 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 12 N2 - BACKGROUND: The aim of this study was to evaluate the efficiency of a simple prototype device for training respiratory muscles in lung function, respiratory muscle strength, walking capacity, quality of life (QOL), dyspnea, and oxidative stress in patients with COPD. METHODS: Thirty COPD patients with moderate severity of the disease were randomized into three groups: control (n=10, 6 males and 4 females), standard training (n=10, 4 males and 6 females), and prototype device (n=10, 5 males and 5 females). Respiratory muscle strength (maximal inspiratory pressure [PImax] and maximal expiratory pressure [PEmax]), lung function (forced vital capacity [FVC], percentage of FVC, forced expiratory volume in 1 second [FEV1], percentage of FEV1 [FEV1%], and FEV1/FVC), 6-minute walking distance (6MWD), QOL, and oxidative stress markers (total antioxidant capacity [TAC]), glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) were evaluated before and after 6 weeks of training. Moreover, dyspnea scores were assessed before; during week 2, 4, and 6 of training; and at rest after training. RESULTS: All parameters between the groups had no statistical difference before training, and no statistical change in the control group after week 6. FVC, FEV1/FVC, PImax, PEmax, QOL, MDA, and NO showed significant changes after 6 weeks of training with either the standard or prototype device, compared to pre-training. FEV1, FEV1%, 6MWD, TAC, and GSH data did not change statistically. Furthermore, the results of significant changes in all parameters were not statistically different between training groups using the standard and prototype device. The peak dyspnea scores increased significantly in week 4 and 6 when applying the standard or prototype device, and then lowered significantly at rest after 6 weeks of training, compared to pre-training. CONCLUSION: This study proposes that a simple prototype device can be used clinically in COPD patients as a standard device to train respiratory muscles, improving lung function and QOL, as well as involving MDA and NO levels. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/28553094/Effects_of_a_simple_prototype_respiratory_muscle_trainer_on_respiratory_muscle_strength_quality_of_life_and_dyspnea_and_oxidative_stress_in_COPD_patients:_a_preliminary_study_ DB - PRIME DP - Unbound Medicine ER -