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Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma.
Pathol Res Pract. 2017 Jul; 213(7):842-847.PR

Abstract

Prediction of lymph node metastasis in esophageal squamous cell carcinoma (ESCC) is very important to have prognostic significance. The objective of this study which involved a relatively large number of ESCC patients was to investigate the correlated factors for lymph node metastasis and prognosis in ESCC. We analyzed a retrospective review of 446 patients with ESCC treated by esophagectomy between January 2010 and July 2016. The relationship between lymph node metastasis and clinicopathological parameters were analyzed. The association between overall survival and clinicopathological factors were evaluated using univariate and multivariable Cox regression models. In the present study, 36.8% esophageal squamous cell carcinoma patients were histologically shown to have lymph node metastasis. Lymph node metastasis was closely correlated with tumor differentiation (p=0.016), perineural invasion (p=0.022), advanced stage tumor (p<0.001) and venous invasion (p<0.001). Kaplan-Meier survival analysis revealed that patients with tumor size, higher T stage, perineuronal invasion, lymph node metastasis, N stage and LNR higher than 0.2 had unfavorable prognosis (p<0.05). The univariate analysis revealed for overall survival that tumor size, pathological stage, perineuronal invasion, lymph metastasis, N stage, involved LNR were relevant prognostic indicators. Furthermore, tumor size, lymph metastasis, N stage and LNR could as independent prognostic factors.

Authors+Show Affiliations

The Department of Pathology, First Teaching Hospital of Xinjiang Medical University, Xinjiang, China.The Department of Pathology, The Second Hospital Affiliated to Henan Medical College of Traditional Chinese Medicine, Henan, China.The Department of Pathology, First Teaching Hospital of Xinjiang Medical University, Xinjiang, China.The Department of Pathology, First Teaching Hospital of Xinjiang Medical University, Xinjiang, China. Electronic address: yuqingm0928@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28554754

Citation

Wang, Hui, et al. "Prognostic Significance of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma." Pathology, Research and Practice, vol. 213, no. 7, 2017, pp. 842-847.
Wang H, Deng F, Liu Q, et al. Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma. Pathol Res Pract. 2017;213(7):842-847.
Wang, H., Deng, F., Liu, Q., & Ma, Y. (2017). Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma. Pathology, Research and Practice, 213(7), 842-847. https://doi.org/10.1016/j.prp.2017.01.023
Wang H, et al. Prognostic Significance of Lymph Node Metastasis in Esophageal Squamous Cell Carcinoma. Pathol Res Pract. 2017;213(7):842-847. PubMed PMID: 28554754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of lymph node metastasis in esophageal squamous cell carcinoma. AU - Wang,Hui, AU - Deng,Feiyan, AU - Liu,Qian, AU - Ma,Yuqing, Y1 - 2017/02/03/ PY - 2016/11/14/received PY - 2017/01/30/revised PY - 2017/01/30/accepted PY - 2017/5/31/pubmed PY - 2018/4/3/medline PY - 2017/5/31/entrez KW - Clinicopathological factors KW - Esophageal squamous cell carcinoma KW - Lymph node KW - Perineural invasion KW - Prognosis SP - 842 EP - 847 JF - Pathology, research and practice JO - Pathol Res Pract VL - 213 IS - 7 N2 - Prediction of lymph node metastasis in esophageal squamous cell carcinoma (ESCC) is very important to have prognostic significance. The objective of this study which involved a relatively large number of ESCC patients was to investigate the correlated factors for lymph node metastasis and prognosis in ESCC. We analyzed a retrospective review of 446 patients with ESCC treated by esophagectomy between January 2010 and July 2016. The relationship between lymph node metastasis and clinicopathological parameters were analyzed. The association between overall survival and clinicopathological factors were evaluated using univariate and multivariable Cox regression models. In the present study, 36.8% esophageal squamous cell carcinoma patients were histologically shown to have lymph node metastasis. Lymph node metastasis was closely correlated with tumor differentiation (p=0.016), perineural invasion (p=0.022), advanced stage tumor (p<0.001) and venous invasion (p<0.001). Kaplan-Meier survival analysis revealed that patients with tumor size, higher T stage, perineuronal invasion, lymph node metastasis, N stage and LNR higher than 0.2 had unfavorable prognosis (p<0.05). The univariate analysis revealed for overall survival that tumor size, pathological stage, perineuronal invasion, lymph metastasis, N stage, involved LNR were relevant prognostic indicators. Furthermore, tumor size, lymph metastasis, N stage and LNR could as independent prognostic factors. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/28554754/Prognostic_significance_of_lymph_node_metastasis_in_esophageal_squamous_cell_carcinoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(16)30660-4 DB - PRIME DP - Unbound Medicine ER -