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Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study.
Clin Sci (Lond). 1988 Nov; 75(5):477-80.CS

Abstract

1. Membrane fluidity of erythrocytes and cultured vascular smooth muscle cells was studied in spontaneously hypertensive rats (SHR; Okamoto and Aoki strains) by means of an electron spin resonance (e.s.r.) and a spin-label technique. 2. The values of outer hyperfine splitting (2T') and of the order parameter (S) determined from e.s.r. spectra for a fatty acid spin-label agent (5-nitroxy stearate) were significantly higher in erythrocytes of SHR (4 and 10-13 weeks of age) than in those of age-matched Wistar-Kyoto rats (WKY). This finding suggests that the membrane fluidity of erythrocytes might be decreased in SHR. 3. The fluidity of cultured vascular smooth muscle cells obtained from 10-13-week-old SHR was also reduced compared with that from WKY. 4. These results suggest that the decreased membrane fluidity might be a genetically determined abnormality of the cell membranes in SHR.

Authors+Show Affiliations

Department of Medicine, Wakayama Medical College, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2855477

Citation

Tsuda, K, et al. "Decreased Membrane Fluidity of Erythrocytes and Cultured Vascular Smooth Muscle Cells in Spontaneously Hypertensive Rats: an Electron Spin Resonance Study." Clinical Science (London, England : 1979), vol. 75, no. 5, 1988, pp. 477-80.
Tsuda K, Tsuda S, Minatogawa Y, et al. Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study. Clin Sci (Lond). 1988;75(5):477-80.
Tsuda, K., Tsuda, S., Minatogawa, Y., Iwahashi, H., Kido, R., & Masuyama, Y. (1988). Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study. Clinical Science (London, England : 1979), 75(5), 477-80.
Tsuda K, et al. Decreased Membrane Fluidity of Erythrocytes and Cultured Vascular Smooth Muscle Cells in Spontaneously Hypertensive Rats: an Electron Spin Resonance Study. Clin Sci (Lond). 1988;75(5):477-80. PubMed PMID: 2855477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study. AU - Tsuda,K, AU - Tsuda,S, AU - Minatogawa,Y, AU - Iwahashi,H, AU - Kido,R, AU - Masuyama,Y, PY - 1988/11/1/pubmed PY - 1988/11/1/medline PY - 1988/11/1/entrez SP - 477 EP - 80 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 75 IS - 5 N2 - 1. Membrane fluidity of erythrocytes and cultured vascular smooth muscle cells was studied in spontaneously hypertensive rats (SHR; Okamoto and Aoki strains) by means of an electron spin resonance (e.s.r.) and a spin-label technique. 2. The values of outer hyperfine splitting (2T') and of the order parameter (S) determined from e.s.r. spectra for a fatty acid spin-label agent (5-nitroxy stearate) were significantly higher in erythrocytes of SHR (4 and 10-13 weeks of age) than in those of age-matched Wistar-Kyoto rats (WKY). This finding suggests that the membrane fluidity of erythrocytes might be decreased in SHR. 3. The fluidity of cultured vascular smooth muscle cells obtained from 10-13-week-old SHR was also reduced compared with that from WKY. 4. These results suggest that the decreased membrane fluidity might be a genetically determined abnormality of the cell membranes in SHR. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/2855477/Decreased_membrane_fluidity_of_erythrocytes_and_cultured_vascular_smooth_muscle_cells_in_spontaneously_hypertensive_rats:_an_electron_spin_resonance_study_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/cs0750477 DB - PRIME DP - Unbound Medicine ER -