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Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis.
Med Sci Monit. 2017 May 30; 23:2619-2624.MS

Abstract

BACKGROUND

Ankylosing spondylitis (AS) is a chronic autoimmune disease that involves the imbalance of peripheral tolerance possibly caused by the negative signal of activated T cells. The polymorphisms in the human protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene have been pointed out to be related to the pathogenesis of AS, but conclusions over this issue remain contradictory. We attempted to give a more precise conclusion about the effects of PTPN22 polymorphisms on AS risk by means of a meta-analysis. MATERIAL AND

METHODS

PubMed, Embase, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies published in the English or Chinese language. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed- or random-effects model to evaluate the correlation between PTPN22 rs2488457, rs1217414, and rs2476601 polymorphisms and AS susceptibility. Sensitivity analysis was also carried out to detect the stability of the results.

RESULTS

The present meta-analysis showed a positive correlation of both PTPN22 rs2488457 and rs1217414 polymorphisms with AS risk under CC vs. GG, CC + GC vs. GG, CC vs. GC + GG, allele C vs. allele G (OR=1.39, 95% CI=1.04-1.85, P=0.646; OR=1.29, 95% CI=1.03-1.62, P=0.426; OR=1.26, 95% CI=1.02-1.56, P=0.971; OR=1.20, 95% CI=1.05-1.38, P=0.571), and TT vs. CC and TT vs. CT + CC models (OR=3.83, 95% CI=1.11-13.24, P=0.196; OR=3.83, 95% CI=1.09-13.42, P=0.244), respectively.

CONCLUSIONS

PTPN22 rs2488457 and rs1217414 polymorphisms may be risk factors for AS occurrence.

Authors+Show Affiliations

Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China (mainland).

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28555069

Citation

Wang, Weiming, et al. "Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: a Meta-analysis." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 23, 2017, pp. 2619-2624.
Wang W, Meng X, Liu Y, et al. Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis. Med Sci Monit. 2017;23:2619-2624.
Wang, W., Meng, X., Liu, Y., Ma, X., Zhang, Q., Li, C., Li, C., & Ren, L. (2017). Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 2619-2624.
Wang W, et al. Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: a Meta-analysis. Med Sci Monit. 2017 May 30;23:2619-2624. PubMed PMID: 28555069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Protein Tyrosine Phosphatase Non-Receptor Type 22 (PTPN22) Polymorphisms and Risk of Ankylosing Spondylitis: A Meta-analysis. AU - Wang,Weiming, AU - Meng,Xiantao, AU - Liu,Yupeng, AU - Ma,Xiaojun, AU - Zhang,Qian, AU - Li,Chunhui, AU - Li,Chenye, AU - Ren,Liubao, Y1 - 2017/05/30/ PY - 2017/5/31/entrez PY - 2017/5/31/pubmed PY - 2018/3/27/medline SP - 2619 EP - 2624 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 23 N2 - BACKGROUND Ankylosing spondylitis (AS) is a chronic autoimmune disease that involves the imbalance of peripheral tolerance possibly caused by the negative signal of activated T cells. The polymorphisms in the human protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene have been pointed out to be related to the pathogenesis of AS, but conclusions over this issue remain contradictory. We attempted to give a more precise conclusion about the effects of PTPN22 polymorphisms on AS risk by means of a meta-analysis. MATERIAL AND METHODS PubMed, Embase, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies published in the English or Chinese language. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed- or random-effects model to evaluate the correlation between PTPN22 rs2488457, rs1217414, and rs2476601 polymorphisms and AS susceptibility. Sensitivity analysis was also carried out to detect the stability of the results. RESULTS The present meta-analysis showed a positive correlation of both PTPN22 rs2488457 and rs1217414 polymorphisms with AS risk under CC vs. GG, CC + GC vs. GG, CC vs. GC + GG, allele C vs. allele G (OR=1.39, 95% CI=1.04-1.85, P=0.646; OR=1.29, 95% CI=1.03-1.62, P=0.426; OR=1.26, 95% CI=1.02-1.56, P=0.971; OR=1.20, 95% CI=1.05-1.38, P=0.571), and TT vs. CC and TT vs. CT + CC models (OR=3.83, 95% CI=1.11-13.24, P=0.196; OR=3.83, 95% CI=1.09-13.42, P=0.244), respectively. CONCLUSIONS PTPN22 rs2488457 and rs1217414 polymorphisms may be risk factors for AS occurrence. SN - 1643-3750 UR - https://www.unboundmedicine.com/medline/citation/28555069/Association_Between_Protein_Tyrosine_Phosphatase_Non_Receptor_Type_22__PTPN22__Polymorphisms_and_Risk_of_Ankylosing_Spondylitis:_A_Meta_analysis_ L2 - https://www.medscimonit.com/download/index/idArt/901083 DB - PRIME DP - Unbound Medicine ER -