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Acute nutritional axonal neuropathy.
Muscle Nerve. 2018 Jan; 57(1):33-39.MN

Abstract

INTRODUCTION

This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia.

METHODS

Retrospective analysis of clinical, electrodiagnostic, and laboratory data of patients with acute axonal neuropathy.

RESULTS

Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2-12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein. Vitamin B6 was low in half and thiamine was low in all patients when obtained before supplementation. Patients improved with weight gain and vitamin supplementation, with motor greater than sensory recovery.

DISCUSSION

We suggest that acute or subacute axonal neuropathy in patients with weight loss or vomiting associated with alcohol abuse, BS, or dietary deficiency is one syndrome, caused by micronutrient deficiencies. Muscle Nerve 57: 33-39, 2018.

Authors+Show Affiliations

University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, 14642, USA.University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, 14642, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28556429

Citation

Hamel, Johanna, and Eric L. Logigian. "Acute Nutritional Axonal Neuropathy." Muscle & Nerve, vol. 57, no. 1, 2018, pp. 33-39.
Hamel J, Logigian EL. Acute nutritional axonal neuropathy. Muscle Nerve. 2018;57(1):33-39.
Hamel, J., & Logigian, E. L. (2018). Acute nutritional axonal neuropathy. Muscle & Nerve, 57(1), 33-39. https://doi.org/10.1002/mus.25702
Hamel J, Logigian EL. Acute Nutritional Axonal Neuropathy. Muscle Nerve. 2018;57(1):33-39. PubMed PMID: 28556429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute nutritional axonal neuropathy. AU - Hamel,Johanna, AU - Logigian,Eric L, Y1 - 2017/06/19/ PY - 2017/01/14/received PY - 2017/05/21/revised PY - 2017/05/23/accepted PY - 2017/5/31/pubmed PY - 2017/12/13/medline PY - 2017/5/31/entrez KW - Guillain-Barre syndrome KW - alcohol KW - neuropathic pain KW - nutritional KW - peripheral neuropathy SP - 33 EP - 39 JF - Muscle & nerve JO - Muscle Nerve VL - 57 IS - 1 N2 - INTRODUCTION: This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia. METHODS: Retrospective analysis of clinical, electrodiagnostic, and laboratory data of patients with acute axonal neuropathy. RESULTS: Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2-12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein. Vitamin B6 was low in half and thiamine was low in all patients when obtained before supplementation. Patients improved with weight gain and vitamin supplementation, with motor greater than sensory recovery. DISCUSSION: We suggest that acute or subacute axonal neuropathy in patients with weight loss or vomiting associated with alcohol abuse, BS, or dietary deficiency is one syndrome, caused by micronutrient deficiencies. Muscle Nerve 57: 33-39, 2018. SN - 1097-4598 UR - https://www.unboundmedicine.com/medline/citation/28556429/Acute_nutritional_axonal_neuropathy_ L2 - https://doi.org/10.1002/mus.25702 DB - PRIME DP - Unbound Medicine ER -