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Hydrogen Sulfide and Polysulfide Signaling.
Antioxid Redox Signal. 2017 Oct 01; 27(10):619-621.AR

Abstract

Hydrogen sulfide (H2S) has been demonstrated to have physiological roles such as neuromodulation, vascular tone regulation, cytoprotection, oxygen sensing, inflammatory regulation, and cell growth. Recently, hydrogen polysulfides (H2Sn) have been found to be produced by 3-mercaptopyruvate sulfurtransferase and to regulate the activity of ion channels, tumor suppressers, and protein kinases. Furthermore, some of the effects previously reported to be mediated by H2S are now ascribed to H2Sn. Cysteine persulfide and cysteine polysulfide may also be involved in cellular redox regulation. The chemical interaction between H2S and nitric oxide (NO) can also produce H2Sn, nitroxyl, and nitrosopersulfide, suggesting their involvement in the reactions previously thought to be mediated by NO alone. This Forum focuses on and critically discusses the recent progress in the study of H2Sn, H2S, and NO as well as other per- or polysulfide species. Antioxid. Redox Signal. 00, 000-000.

Authors+Show Affiliations

National Institute of Neuroscience, National Center of Neurology and Psychiatry , Kodaira, Japan .

Pub Type(s)

Editorial
Introductory Journal Article

Language

eng

PubMed ID

28558483

Citation

Kimura, Hideo. "Hydrogen Sulfide and Polysulfide Signaling." Antioxidants & Redox Signaling, vol. 27, no. 10, 2017, pp. 619-621.
Kimura H. Hydrogen Sulfide and Polysulfide Signaling. Antioxid Redox Signal. 2017;27(10):619-621.
Kimura, H. (2017). Hydrogen Sulfide and Polysulfide Signaling. Antioxidants & Redox Signaling, 27(10), 619-621. https://doi.org/10.1089/ars.2017.7076
Kimura H. Hydrogen Sulfide and Polysulfide Signaling. Antioxid Redox Signal. 2017 Oct 1;27(10):619-621. PubMed PMID: 28558483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen Sulfide and Polysulfide Signaling. A1 - Kimura,Hideo, Y1 - 2017/06/27/ PY - 2017/6/1/pubmed PY - 2018/3/10/medline PY - 2017/6/1/entrez KW - 3MST KW - hydrogen sulfide KW - nitric oxide KW - polysulfides KW - signaling KW - thiol SP - 619 EP - 621 JF - Antioxidants & redox signaling JO - Antioxid Redox Signal VL - 27 IS - 10 N2 - Hydrogen sulfide (H2S) has been demonstrated to have physiological roles such as neuromodulation, vascular tone regulation, cytoprotection, oxygen sensing, inflammatory regulation, and cell growth. Recently, hydrogen polysulfides (H2Sn) have been found to be produced by 3-mercaptopyruvate sulfurtransferase and to regulate the activity of ion channels, tumor suppressers, and protein kinases. Furthermore, some of the effects previously reported to be mediated by H2S are now ascribed to H2Sn. Cysteine persulfide and cysteine polysulfide may also be involved in cellular redox regulation. The chemical interaction between H2S and nitric oxide (NO) can also produce H2Sn, nitroxyl, and nitrosopersulfide, suggesting their involvement in the reactions previously thought to be mediated by NO alone. This Forum focuses on and critically discusses the recent progress in the study of H2Sn, H2S, and NO as well as other per- or polysulfide species. Antioxid. Redox Signal. 00, 000-000. SN - 1557-7716 UR - https://www.unboundmedicine.com/medline/citation/28558483/Hydrogen_Sulfide_and_Polysulfide_Signaling_ L2 - https://www.liebertpub.com/doi/10.1089/ars.2017.7076?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -