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Role of SDF-1α/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma.
Biosci Rep 2017; 37(4)BR

Abstract

The present study aims to explore the role of stromal cell-derived factor-1α (SDF-1α)/stromal cell-derived factor receptor-4 (CXCR4) signaling pathway to the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2009 to December 2010, 102 patients with NPC and 80 patients with chronic nasopharyngitis were enrolled for the study. Immunohistochemical staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting were employed to determine the expressions of SDF-1α and CXCR4 proteins in NPC tissues and chronic nasopharyngitis tissues. Chi-square test was conducted to analyze the associations of the expressions of SDF-1α and CXCR4 proteins with the clinicopathological features of NPC patients. Spearman rank correlation analysis was used to analyze the correlation between the SDF-1α protein expression and CXCR4 protein expression. The mRNA and protein expressions of SDF-1α and CXCR4 in NPC tissues were significantly higher than those in chronic nasopharyngitis tissues. The expressions of SDF-1α and CXCR4 proteins showed associations with T staging, N staging, tumor node metastasis (TNM) staging, skull base invasion, and cervical lymph node metastasis of NPC patients. Compared with NPC patients showing negative expressions of SDF-1α and CXCR4 proteins, those with positive expressions of SDF-1α and CXCR4 proteins had a significantly shorter survival time. SDF-1α protein, CXCR4 protein, EBV-IgG status, T staging, N staging, TNM staging, skull base invasion, and cervical lymph node metastasis were independent risk factors for the prognosis of NPC. The findings indicated that SDF-1α/CXCR4 signaling pathway might be associated with the clinicopathological features and prognosis of patients with NPC.

Authors+Show Affiliations

Department of ENT, Linyi People's Hospital, Linyi City 276003, P.R. China.Department of ENT, Linyi People's Hospital, Linyi City 276003, P.R. China.Department of Genetic Laboratory, Women and Children's Hospital of Linyi, Linyi City 276016, P.R. China lihuafeng_lhf6@163.com.Department of ENT, Linyi People's Hospital, Linyi City 276003, P.R. China.Department of ENT, Linyi People's Hospital, Linyi City 276003, P.R. China.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

28559386

Citation

Li, Yun-Ling, et al. "Role of SDF-1α/CXCR4 Signaling Pathway in Clinicopathological Features and Prognosis of Patients With Nasopharyngeal Carcinoma." Bioscience Reports, vol. 37, no. 4, 2017.
Li YL, Li YF, Li HF, et al. Role of SDF-1α/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. Biosci Rep. 2017;37(4).
Li, Y. L., Li, Y. F., Li, H. F., Lv, H. Q., & Sun, D. Z. (2017). Role of SDF-1α/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. Bioscience Reports, 37(4), doi:10.1042/BSR20170144.
Li YL, et al. Role of SDF-1α/CXCR4 Signaling Pathway in Clinicopathological Features and Prognosis of Patients With Nasopharyngeal Carcinoma. Biosci Rep. 2017 Aug 31;37(4) PubMed PMID: 28559386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of SDF-1α/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma. AU - Li,Yun-Ling, AU - Li,Yu-Fen, AU - Li,Hua-Feng, AU - Lv,Huai-Qing, AU - Sun,De-Zhong, Y1 - 2017/07/12/ PY - 2017/02/15/received PY - 2017/05/22/revised PY - 2017/05/30/accepted PY - 2017/6/1/pubmed PY - 2018/4/6/medline PY - 2017/6/1/entrez KW - Clinicopathological features KW - Nasopharyngeal carcinoma KW - Prognosis KW - Signaling pathway KW - Stromal cell derived factor receptor-4 KW - Stromal cell derived factor-1α JF - Bioscience reports JO - Biosci. Rep. VL - 37 IS - 4 N2 - The present study aims to explore the role of stromal cell-derived factor-1α (SDF-1α)/stromal cell-derived factor receptor-4 (CXCR4) signaling pathway to the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2009 to December 2010, 102 patients with NPC and 80 patients with chronic nasopharyngitis were enrolled for the study. Immunohistochemical staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting were employed to determine the expressions of SDF-1α and CXCR4 proteins in NPC tissues and chronic nasopharyngitis tissues. Chi-square test was conducted to analyze the associations of the expressions of SDF-1α and CXCR4 proteins with the clinicopathological features of NPC patients. Spearman rank correlation analysis was used to analyze the correlation between the SDF-1α protein expression and CXCR4 protein expression. The mRNA and protein expressions of SDF-1α and CXCR4 in NPC tissues were significantly higher than those in chronic nasopharyngitis tissues. The expressions of SDF-1α and CXCR4 proteins showed associations with T staging, N staging, tumor node metastasis (TNM) staging, skull base invasion, and cervical lymph node metastasis of NPC patients. Compared with NPC patients showing negative expressions of SDF-1α and CXCR4 proteins, those with positive expressions of SDF-1α and CXCR4 proteins had a significantly shorter survival time. SDF-1α protein, CXCR4 protein, EBV-IgG status, T staging, N staging, TNM staging, skull base invasion, and cervical lymph node metastasis were independent risk factors for the prognosis of NPC. The findings indicated that SDF-1α/CXCR4 signaling pathway might be associated with the clinicopathological features and prognosis of patients with NPC. SN - 1573-4935 UR - https://www.unboundmedicine.com/medline/citation/28559386/Role_of_SDF_1α/CXCR4_signaling_pathway_in_clinicopathological_features_and_prognosis_of_patients_with_nasopharyngeal_carcinoma_ L2 - http://www.bioscirep.org/cgi/pmidlookup?view=long&pmid=28559386 DB - PRIME DP - Unbound Medicine ER -