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A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months.
J Nutr. 2017 07; 147(7):1348-1355.JN

Abstract

Background:

Health benefits of a Mediterranean dietary pattern have been shown. However, there are few data on the effects of increased adherence to a Mediterranean diet (MedDiet) in non-Mediterranean countries.

Objective:

We aimed to determine whether adherence to a MedDiet would result in changes in plasma lipids, glucose and insulin, high-sensitivity C-reactive protein (hs-CRP), and F2-isoprostanes (F2-IsoPs) in an Australian population.

Methods:

The study was a 6-mo parallel, randomized, controlled dietary intervention trial. We recruited 166 participants aged ≥65 y. Participants were stratified on body mass index, sex, and age and assigned to receive either a MedDiet or a habitual diet (HabDiet). The primary outcome was cognitive function, reported elsewhere. As secondary outcomes, assessment of fasting total, LDL, and HDL cholesterol; triglycerides (TGs); glucose; insulin; hs-CRP; and F2-IsoPs was completed at baseline and at 3 and 6 mo. The MedDiet group followed a prescribed diet containing 15-45 mL extra-virgin olive oil/d, abundant vegetables, fruit, nuts, legumes, and whole grains, as well as moderate fish, poultry, and dairy foods. Dietary intake was measured by 3-d weighed food records at baseline and at 2 and 4 mo. Results were analyzed by using linear mixed-effects models.

Results:

Compared with the HabDiet, the MedDiet resulted in lower TGs at 3 mo (mean difference: -0.15 mmol/L; 95% CI: -0.23, -0.07 mmol/L; P < 0.001) and 6 mo (mean difference: -0.09 mmol/L; 95% CI: -0.18, -0.01 mmol/L; P = 0.03) and lower F2-IsoPs at 3 mo (mean difference: -103.5 pmol/L; 95% CI: -154.2, -52.7 pmol/L; P < 0.001) and 6 mo (-65.4 pmol/L; 95% CI: -117.1, -13.7 pmol/L; P < 0.001). Lipoprotein, glucose and insulin, and hs-CRP concentrations were not significantly different between groups.

Conclusion:

A high adherence to a MedDiet for 6 mo resulted in a significant reduction in TGs and F2-IsoPs among older Australians. This trial was registered at clinicaltrials.gov as ACTRN12613000602729.

Authors+Show Affiliations

Alliance for Research in Exercise, Nutrition, and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia; courtney.davis@mymail.unisa.edu.au.School of Psychology, Social Work, and Social Policy, University of South Australia, Magill, Adelaide, South Australia, Australia.School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; and.Flinders Centre for Epidemiology and Biostatistics, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.Alliance for Research in Exercise, Nutrition, and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28566524

Citation

Davis, Courtney Rose, et al. "A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides Among Older Australian Men and Women After 6 Months." The Journal of Nutrition, vol. 147, no. 7, 2017, pp. 1348-1355.
Davis CR, Bryan J, Hodgson JM, et al. A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months. J Nutr. 2017;147(7):1348-1355.
Davis, C. R., Bryan, J., Hodgson, J. M., Woodman, R., & Murphy, K. J. (2017). A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months. The Journal of Nutrition, 147(7), 1348-1355. https://doi.org/10.3945/jn.117.248419
Davis CR, et al. A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides Among Older Australian Men and Women After 6 Months. J Nutr. 2017;147(7):1348-1355. PubMed PMID: 28566524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months. AU - Davis,Courtney Rose, AU - Bryan,Janet, AU - Hodgson,Jonathan M, AU - Woodman,Richard, AU - Murphy,Karen J, Y1 - 2017/05/31/ PY - 2017/01/31/received PY - 2017/03/06/revised PY - 2017/05/03/accepted PY - 2017/6/2/pubmed PY - 2017/7/25/medline PY - 2017/6/2/entrez KW - F2-isoprostanes KW - Mediterranean diet KW - cardiovascular risk factors KW - older Australians KW - oxidative stress SP - 1348 EP - 1355 JF - The Journal of nutrition JO - J. Nutr. VL - 147 IS - 7 N2 - Background: Health benefits of a Mediterranean dietary pattern have been shown. However, there are few data on the effects of increased adherence to a Mediterranean diet (MedDiet) in non-Mediterranean countries.Objective: We aimed to determine whether adherence to a MedDiet would result in changes in plasma lipids, glucose and insulin, high-sensitivity C-reactive protein (hs-CRP), and F2-isoprostanes (F2-IsoPs) in an Australian population.Methods: The study was a 6-mo parallel, randomized, controlled dietary intervention trial. We recruited 166 participants aged ≥65 y. Participants were stratified on body mass index, sex, and age and assigned to receive either a MedDiet or a habitual diet (HabDiet). The primary outcome was cognitive function, reported elsewhere. As secondary outcomes, assessment of fasting total, LDL, and HDL cholesterol; triglycerides (TGs); glucose; insulin; hs-CRP; and F2-IsoPs was completed at baseline and at 3 and 6 mo. The MedDiet group followed a prescribed diet containing 15-45 mL extra-virgin olive oil/d, abundant vegetables, fruit, nuts, legumes, and whole grains, as well as moderate fish, poultry, and dairy foods. Dietary intake was measured by 3-d weighed food records at baseline and at 2 and 4 mo. Results were analyzed by using linear mixed-effects models.Results: Compared with the HabDiet, the MedDiet resulted in lower TGs at 3 mo (mean difference: -0.15 mmol/L; 95% CI: -0.23, -0.07 mmol/L; P < 0.001) and 6 mo (mean difference: -0.09 mmol/L; 95% CI: -0.18, -0.01 mmol/L; P = 0.03) and lower F2-IsoPs at 3 mo (mean difference: -103.5 pmol/L; 95% CI: -154.2, -52.7 pmol/L; P < 0.001) and 6 mo (-65.4 pmol/L; 95% CI: -117.1, -13.7 pmol/L; P < 0.001). Lipoprotein, glucose and insulin, and hs-CRP concentrations were not significantly different between groups.Conclusion: A high adherence to a MedDiet for 6 mo resulted in a significant reduction in TGs and F2-IsoPs among older Australians. This trial was registered at clinicaltrials.gov as ACTRN12613000602729. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/28566524/A_Mediterranean_Diet_Reduces_F2_Isoprostanes_and_Triglycerides_among_Older_Australian_Men_and_Women_after_6_Months_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.117.248419 DB - PRIME DP - Unbound Medicine ER -