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Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children.
Eur J Pediatr 2017; 176(7):971-978EJ

Abstract

Children with post-infectious bronchiolitis obliterans (PIBO) are frequently hospitalized with acute exacerbation, but clinical differentiation of PIBO exacerbation from acute bronchiolitis is often challenging, which may result in treatment delay and chronic lung function impairment. We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation. Thirty-seven children admitted with acute exacerbation of PIBO were enrolled and studied retrospectively. Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography. Serum levels of YKL-40, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and platelet-derived growth factor (PDGF)-BB were measured on admission. The biomarkers were also examined in children admitted with acute bronchiolitis serving as positive controls (N = 30) and in age-matched controls (N = 20). Only YKL-40 levels were found to be significantly higher in PIBO patients with exacerbation compared with that in bronchiolitis patients and showed a positive correlation with the severity of disease before diagnosis of PIBO.

CONCLUSION

Our results suggest that measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children. What is Known: • The children with post-infectious BO (PIBO) usually have recurrent wheezing and need frequent hospitalization due to acute exacerbation during the first disease years. • Clinical differentiation of PIBO exacerbation from acute bronchiolitis in young children is often challenging, which may result in treatment delay and chronic lung function impairment. What is New: • Measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, Catholic University of Daegu, Namgu Duryugongwon Ro 17-33, Daegu, 42472, South Korea.Department of Pediatrics, School of Medicine, Catholic University of Daegu, Namgu Duryugongwon Ro 17-33, Daegu, 42472, South Korea.Department of Pediatrics, School of Medicine, Catholic University of Daegu, Namgu Duryugongwon Ro 17-33, Daegu, 42472, South Korea. hlchung@cu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28567534

Citation

Jang, Yoon Young, et al. "Serum YKL-40 Levels May Help Distinguish Exacerbation of Post-infectious Bronchiolitis Obliterans From Acute Bronchiolitis in Young Children." European Journal of Pediatrics, vol. 176, no. 7, 2017, pp. 971-978.
Jang YY, Park HJ, Chung HL. Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. Eur J Pediatr. 2017;176(7):971-978.
Jang, Y. Y., Park, H. J., & Chung, H. L. (2017). Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. European Journal of Pediatrics, 176(7), pp. 971-978. doi:10.1007/s00431-017-2940-x.
Jang YY, Park HJ, Chung HL. Serum YKL-40 Levels May Help Distinguish Exacerbation of Post-infectious Bronchiolitis Obliterans From Acute Bronchiolitis in Young Children. Eur J Pediatr. 2017;176(7):971-978. PubMed PMID: 28567534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children. AU - Jang,Yoon Young, AU - Park,Hye Jin, AU - Chung,Hai Lee, Y1 - 2017/06/01/ PY - 2016/12/08/received PY - 2017/05/22/accepted PY - 2017/05/18/revised PY - 2017/6/2/pubmed PY - 2018/4/5/medline PY - 2017/6/2/entrez KW - Children KW - Growth factor KW - Post-infectious bronchiolitis obliterans KW - YKL-40 SP - 971 EP - 978 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 176 IS - 7 N2 - : Children with post-infectious bronchiolitis obliterans (PIBO) are frequently hospitalized with acute exacerbation, but clinical differentiation of PIBO exacerbation from acute bronchiolitis is often challenging, which may result in treatment delay and chronic lung function impairment. We aimed to examine whether serum YKL-40 and growth factors could be markers for PIBO exacerbation. Thirty-seven children admitted with acute exacerbation of PIBO were enrolled and studied retrospectively. Diagnosis of PIBO was based on clinical history of acute respiratory infection followed by persistent airway obstruction and characteristic findings in high-resolution computed tomography. Serum levels of YKL-40, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, and platelet-derived growth factor (PDGF)-BB were measured on admission. The biomarkers were also examined in children admitted with acute bronchiolitis serving as positive controls (N = 30) and in age-matched controls (N = 20). Only YKL-40 levels were found to be significantly higher in PIBO patients with exacerbation compared with that in bronchiolitis patients and showed a positive correlation with the severity of disease before diagnosis of PIBO. CONCLUSION: Our results suggest that measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children. What is Known: • The children with post-infectious BO (PIBO) usually have recurrent wheezing and need frequent hospitalization due to acute exacerbation during the first disease years. • Clinical differentiation of PIBO exacerbation from acute bronchiolitis in young children is often challenging, which may result in treatment delay and chronic lung function impairment. What is New: • Measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children. SN - 1432-1076 UR - https://www.unboundmedicine.com/medline/citation/28567534/Serum_YKL_40_levels_may_help_distinguish_exacerbation_of_post_infectious_bronchiolitis_obliterans_from_acute_bronchiolitis_in_young_children_ L2 - https://dx.doi.org/10.1007/s00431-017-2940-x DB - PRIME DP - Unbound Medicine ER -