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Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis.
Clin Exp Hypertens. 2017; 39(6):553-561.CE

Abstract

Hypertensive crisis is a common clinical situation that presents a high rate of morbidity and mortality and it is characterized by symptomatic rise of blood pressure (BP), systolic (SBP) ≥ 180 mmHg and/or diastolic (DBP) ≥ 120 mmHg. It is classified as emergency (HE) or hypertensive urgency (HU). There is no description of laboratory findings in patients who present acute BP elevation. Thus, this study had the objective to assess the biochemical-metabolic parameters of patients with HC. We studied 74 normotensive individuals (NT), 74 controlled hypertensive patients (ContrHT), 50 subjects with HU, and 78 with HE for evaluating biochemical-metabolic parameters. HE occurs in older individuals and more frequently in those with known hypertension. More patients with HE had dyslipidemia than those with HU (58% vs. 38%). The diastolic BP and heart rate were higher in the HE group (120 mmHg and 87 bpm) compared to ContrHT (71 mmHg and 71 bpm; p < 0.0001) and NT groups (75 mmHg and 68 bpm; p < 0.0001). Glycemia was higher in HE vs. NT and ContrHT (p < 0.05). HDL cholesterol was lower in HE than NT (p = 0.0088). Potassium was lower in HE vs. NT, ContrHT and HU groups (p < 0.05). Creatinine was higher in the HC group vs. NT and ContrHT (p < 0.05). The GFR was significantly lower in HE group vs. HU, ContrHT and NT (p < 0.001). In conclusion, individuals with HC show biochemical alterations when compared to ContrHT and NT. Acute BP elevations are associated with hyperglycemia, dyslipidemia, and higher potassium and creatinine levels and lower renal function. Abbreviations BMI = body mass index BP = blood pressure CH = hypertensive crisis ContrHT = controlled hypertensive DBP = diastolic blood pressure GFR = glomerular filtration rate HbA1c = glycated hemoglobin HDLc = high-density lipoprotein cholesterol HE = hypertensive emergency HPLC = high-performance liquid chromatography HR = heart rate HU = hypertensive urgency JNC 7 = VII Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure LDLc = low-density lipoprotein cholesterol MDRD = Modification of Diet in Renal Disease NT = normotensive RASB = renin-angiotensin system blockers SBP = systolic blood pressure TC = total cholesterol TG = triglycerides.

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a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

c Cardiology and Cardiovascular Surgery Department , Medical School at São José do Rio Preto (FAMERP) , São Paulo , Brazil.

b Molecular Biology Department , State Medical School at São José do Rio Preto (FAMERP) , São Paulo , Brazil.

Vilela-Martin JF

a State Medical School at São José do Rio Preto (FAMERP) , Internal Medicine Department, Hypertension Clinic of FAMERP and Hospital de Base , São José do Rio Preto , São Paulo , Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28569557

Citation

Andrade, Days Oliveira, et al. "Effects of Acute Blood Pressure Elevation On Biochemical-metabolic Parameters in Individuals With Hypertensive Crisis." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 39, no. 6, 2017, pp. 553-561.

Andrade DO, Santos SPO, Pinhel MAS, et al. Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis. Clin Exp Hypertens. 2017;39(6):553-561.

Andrade, D. O., Santos, S. P. O., Pinhel, M. A. S., Valente, F. M., Giannini, M. C., Gregório, M. L., De Godoy, M. F., Souza, D. R. S., & Vilela-Martin, J. F. (2017). Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 39(6), 553-561. https://doi.org/10.1080/10641963.2017.1291661

Andrade DO, et al. Effects of Acute Blood Pressure Elevation On Biochemical-metabolic Parameters in Individuals With Hypertensive Crisis. Clin Exp Hypertens. 2017;39(6):553-561. PubMed PMID: 28569557.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Effects of acute blood pressure elevation on biochemical-metabolic parameters in individuals with hypertensive crisis. AU - Andrade,Days Oliveira, AU - Santos,Sara Patrícia O, AU - Pinhel,Marcela Augusta S, AU - Valente,Flávia Mariana, AU - Giannini,Marcela Cavichiolo, AU - Gregório,Michele Lima, AU - De Godoy,Moacir Fernandes, AU - Souza,Dorotéia Rossi S, AU - Vilela-Martin,José Fernando, Y1 - 2017/06/01/ PY - 2017/6/2/pubmed PY - 2018/4/4/medline PY - 2017/6/2/entrez KW - Biochemistry KW - hypertensive crisis KW - hypertensive emergency KW - hypertensive urgency KW - metabolic changes SP - 553 EP - 561 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin Exp Hypertens VL - 39 IS - 6 N2 - Hypertensive crisis is a common clinical situation that presents a high rate of morbidity and mortality and it is characterized by symptomatic rise of blood pressure (BP), systolic (SBP) ≥ 180 mmHg and/or diastolic (DBP) ≥ 120 mmHg. It is classified as emergency (HE) or hypertensive urgency (HU). There is no description of laboratory findings in patients who present acute BP elevation. Thus, this study had the objective to assess the biochemical-metabolic parameters of patients with HC. We studied 74 normotensive individuals (NT), 74 controlled hypertensive patients (ContrHT), 50 subjects with HU, and 78 with HE for evaluating biochemical-metabolic parameters. HE occurs in older individuals and more frequently in those with known hypertension. More patients with HE had dyslipidemia than those with HU (58% vs. 38%). The diastolic BP and heart rate were higher in the HE group (120 mmHg and 87 bpm) compared to ContrHT (71 mmHg and 71 bpm; p < 0.0001) and NT groups (75 mmHg and 68 bpm; p < 0.0001). Glycemia was higher in HE vs. NT and ContrHT (p < 0.05). HDL cholesterol was lower in HE than NT (p = 0.0088). Potassium was lower in HE vs. NT, ContrHT and HU groups (p < 0.05). Creatinine was higher in the HC group vs. NT and ContrHT (p < 0.05). The GFR was significantly lower in HE group vs. HU, ContrHT and NT (p < 0.001). In conclusion, individuals with HC show biochemical alterations when compared to ContrHT and NT. Acute BP elevations are associated with hyperglycemia, dyslipidemia, and higher potassium and creatinine levels and lower renal function. Abbreviations BMI = body mass index BP = blood pressure CH = hypertensive crisis ContrHT = controlled hypertensive DBP = diastolic blood pressure GFR = glomerular filtration rate HbA1c = glycated hemoglobin HDLc = high-density lipoprotein cholesterol HE = hypertensive emergency HPLC = high-performance liquid chromatography HR = heart rate HU = hypertensive urgency JNC 7 = VII Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure LDLc = low-density lipoprotein cholesterol MDRD = Modification of Diet in Renal Disease NT = normotensive RASB = renin-angiotensin system blockers SBP = systolic blood pressure TC = total cholesterol TG = triglycerides. SN - 1525-6006 UR - https://www.unboundmedicine.com/medline/citation/28569557/Effects_of_acute_blood_pressure_elevation_on_biochemical_metabolic_parameters_in_individuals_with_hypertensive_crisis_ L2 - https://www.tandfonline.com/doi/full/10.1080/10641963.2017.1291661 DB - PRIME DP - Unbound Medicine ER -