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ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF ROSA CANINA L.

Abstract

BACKGROUND

Diabetes mellitus is one of the most common endocrinal disorders and medicinal plants continue to play an important role in the management of this disease. In this study, Rosa canina was investigated for the antioxidant and α-amylase inhibition activities.

MATERIALS AND METHODS

Methanolic extract of Rosa canina was investigated for its potential antioxidant activity. The extracts' total phenolic and flavonoid contents and scavenging capacity for free radicals were evaluated. The α-amylase inhibition assay was also carried.

RESULTS

Rosa canina extract exhibits a total Phenolic and flavonoid levels respectively (21.918 mg GAE/g and 2.647mg ER/g). The free radical scavenging activity was found to be prominent against DPPH with an IC50 of 0.668 mg/ml and against ABTS with an IC50 of 0.467 mg/ml. Extract showed a significant ferric ion reducing activities with an IC50 of4.962 mg/ml.

CONCLUSION

Rosa canina exerted a higher inhibitory activity against α-amylase. The obtained results support the antidiabetic use of rosa canina.

Authors+Show Affiliations

Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.Laboratory SURVEN, National Institute of Nutrition and Food Technology of Tunis, Tunisia.Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Sciences and Technology of Health of Tunis, 176 Bab Souika, BP1006, Tunis, Tunisia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28573216

Citation

Jemaa, Houda Ben, et al. "ANTIOXIDANT ACTIVITY and A-AMYLASE INHIBITORY POTENTIAL of ROSA CANINA L." African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, vol. 14, no. 2, 2017, pp. 1-8.
Jemaa HB, Jemia AB, Khlifi S, et al. ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF ROSA CANINA L. Afr J Tradit Complement Altern Med. 2017;14(2):1-8.
Jemaa, H. B., Jemia, A. B., Khlifi, S., Ahmed, H. B., Slama, F. B., Benzarti, A., Elati, J., & Aouidet, A. (2017). ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF ROSA CANINA L. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM, 14(2), 1-8. https://doi.org/10.21010/ajtcam.v14i2.1
Jemaa HB, et al. ANTIOXIDANT ACTIVITY and A-AMYLASE INHIBITORY POTENTIAL of ROSA CANINA L. Afr J Tradit Complement Altern Med. 2017;14(2):1-8. PubMed PMID: 28573216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ANTIOXIDANT ACTIVITY AND A-AMYLASE INHIBITORY POTENTIAL OF ROSA CANINA L. AU - Jemaa,Houda Ben, AU - Jemia,Amani Ben, AU - Khlifi,Sarra, AU - Ahmed,Halima Ben, AU - Slama,Fethi Ben, AU - Benzarti,Anis, AU - Elati,Jalila, AU - Aouidet,Abdallah, Y1 - 2017/01/13/ PY - 2017/6/3/entrez PY - 2017/6/3/pubmed PY - 2017/8/17/medline KW - Rosa canina KW - antioxidant activity KW - hyperglycemia KW - phytochemical profile KW - α-amylase SP - 1 EP - 8 JF - African journal of traditional, complementary, and alternative medicines : AJTCAM JO - Afr J Tradit Complement Altern Med VL - 14 IS - 2 N2 - BACKGROUND: Diabetes mellitus is one of the most common endocrinal disorders and medicinal plants continue to play an important role in the management of this disease. In this study, Rosa canina was investigated for the antioxidant and α-amylase inhibition activities. MATERIALS AND METHODS: Methanolic extract of Rosa canina was investigated for its potential antioxidant activity. The extracts' total phenolic and flavonoid contents and scavenging capacity for free radicals were evaluated. The α-amylase inhibition assay was also carried. RESULTS: Rosa canina extract exhibits a total Phenolic and flavonoid levels respectively (21.918 mg GAE/g and 2.647mg ER/g). The free radical scavenging activity was found to be prominent against DPPH with an IC50 of 0.668 mg/ml and against ABTS with an IC50 of 0.467 mg/ml. Extract showed a significant ferric ion reducing activities with an IC50 of4.962 mg/ml. CONCLUSION: Rosa canina exerted a higher inhibitory activity against α-amylase. The obtained results support the antidiabetic use of rosa canina. SN - 2505-0044 UR - https://www.unboundmedicine.com/medline/citation/28573216/ANTIOXIDANT_ACTIVITY_AND_A_AMYLASE_INHIBITORY_POTENTIAL_OF_ROSA_CANINA_L_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28573216/ DB - PRIME DP - Unbound Medicine ER -