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Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style.
McGill Sci Undergrad Res J. 2015 Mar; 10(1):31-36.MS

Abstract

BACKGROUND

The current paper aimed to explore the effects of birth weight and the 7-repeat allele in Exon III of the dopamine D4 receptor (DRD4) gene on the development of disorganized attachment, a potential endophenotype of depression. Infants born with low birth weight have been shown to be at higher risk for later neurological impairments, psychological disorders or behavioural problems. The DRD4 gene is critical for the cognitive and emotional processes that are sub-served by neural circuits in the prefrontal cortex. This paper examined the main effect of birth weight and DRD4 on the development of disorganized attachment.

METHODS

Data was used from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. The sample consisted of 251 mother-child dyads with complete data. Attachment style was assessed using the modified separation-reunion procedure.

RESULTS

There was no main effect for birth weight on disorganized attachment, (b = -0.001, p = 0.998). There was, however, a main effect for the DRD4 7-repeat polymorphism on disorganized attachment (b = -1.120, p = 0.004).

LIMITATIONS

Compared to studies of similar design, the sample size in this study was relatively small. Additionally, a significant number of subjects did not have complete data.

CONCLUSIONS

Children without the DRD4 7-repeat allele were more likely to have disorganized attachment than children with the DRD4 7-repeat allele. This indicates that the 7-repeate allele of the DRD4 gene may actually serve as a protective factor against disorganized attachment.

Authors+Show Affiliations

McGill University, Montreal. Centre for Child Development and Mental Health, Jewish General Hospital, Montreal.University de Quebec à Montréal, Montreal.McGill University, Montreal.Hebrew University, Jerusalem.University de Quebec à Montréal, Montreal.McGill University, Montreal.McGill University, Montreal.McGill University, Montreal.Leidon University, Netherlands.McGill University, Montreal.St-Joseph's Healthcare, Hamilton.Dalhousie University, Halifax.Centre for Addiction and Mental Health, Toronto.Ludmer Centre for Neuroinformatics and Mental Health and, Douglas Mental Health University Institute, Montreal.Centre for Addiction and Mental Health, Toronto.McGill University, Montreal. Ludmer Centre for Neuroinformatics and Mental Health and, Douglas Mental Health University Institute, Montreal.McGill University, Montreal. Centre for Child Development and Mental Health, Jewish General Hospital, Montreal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28574063

Citation

Graffi, Justin, et al. "Preschool Children Without 7-repeat DRD4 Gene More Likely to Develop Disorganized Attachment Style." McGill Science Undergraduate Research Journal : MSURJ, vol. 10, no. 1, 2015, pp. 31-36.
Graffi J, Moss E, Jolicoeur-Martineau A, et al. Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style. McGill Science undergraduate research journal : MSURJ. 2015;10(1):31-36.
Graffi, J., Moss, E., Jolicoeur-Martineau, A., Moss, G., Lecompte, V., Pascuzzo, K., Babineau, V., Gordon-Green, C., Mileva-Seitz, V. R., Minde, K., Sassi, R., Carrey, N., Kennedy, J. L., Gaudreau, H., Levitan, R., Meaney, M., & Wazana, A. (2015). Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style. McGill Science Undergraduate Research Journal : MSURJ, 10(1), 31-36.
Graffi J, et al. Preschool Children Without 7-repeat DRD4 Gene More Likely to Develop Disorganized Attachment Style. McGill Science undergraduate research journal : MSURJ. 2015;10(1):31-36. PubMed PMID: 28574063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preschool children without 7-repeat DRD4 gene more likely to develop disorganized attachment style. AU - Graffi,Justin, AU - Moss,Ellen, AU - Jolicoeur-Martineau,Alexia, AU - Moss,Gal, AU - Lecompte,Vanessa, AU - Pascuzzo,Katherine, AU - Babineau,Vanessa, AU - Gordon-Green,Cathryn, AU - Mileva-Seitz,Viara R, AU - Minde,Klaus, AU - Sassi,Roberto, AU - Carrey,Normand, AU - Kennedy,James L, AU - Gaudreau,Helene, AU - Levitan,Robert, AU - Meaney,Michael, AU - Wazana,Ashley, PY - 2017/6/3/entrez PY - 2015/3/1/pubmed PY - 2015/3/1/medline KW - DRD4 KW - depression KW - differential susceptibility KW - disorganized attachment KW - endophenotype KW - low birthweight SP - 31 EP - 36 JF - McGill Science undergraduate research journal : MSURJ VL - 10 IS - 1 N2 - BACKGROUND: The current paper aimed to explore the effects of birth weight and the 7-repeat allele in Exon III of the dopamine D4 receptor (DRD4) gene on the development of disorganized attachment, a potential endophenotype of depression. Infants born with low birth weight have been shown to be at higher risk for later neurological impairments, psychological disorders or behavioural problems. The DRD4 gene is critical for the cognitive and emotional processes that are sub-served by neural circuits in the prefrontal cortex. This paper examined the main effect of birth weight and DRD4 on the development of disorganized attachment. METHODS: Data was used from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. The sample consisted of 251 mother-child dyads with complete data. Attachment style was assessed using the modified separation-reunion procedure. RESULTS: There was no main effect for birth weight on disorganized attachment, (b = -0.001, p = 0.998). There was, however, a main effect for the DRD4 7-repeat polymorphism on disorganized attachment (b = -1.120, p = 0.004). LIMITATIONS: Compared to studies of similar design, the sample size in this study was relatively small. Additionally, a significant number of subjects did not have complete data. CONCLUSIONS: Children without the DRD4 7-repeat allele were more likely to have disorganized attachment than children with the DRD4 7-repeat allele. This indicates that the 7-repeate allele of the DRD4 gene may actually serve as a protective factor against disorganized attachment. SN - 1718-0775 UR - https://www.unboundmedicine.com/medline/citation/28574063/Preschool_children_without_7_repeat_DRD4_gene_more_likely_to_develop_disorganized_attachment_style_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28574063/ DB - PRIME DP - Unbound Medicine ER -