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Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation.

Abstract

Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocyte culture, and chondrocyte implantation. The techniques and their outcomes are discussed in this article.

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  • Authors+Show Affiliations

    ,

    Missouri Orthopaedic Institute, University of Missouri, Virginia Avenue, Columbia, MO, USA.

    Cartilage Repair Center, Brigham and Women's Hospital, Chestnut Hill, MA, USA. Electronic address: AGOMOLL@BWH.HARVARD.EDU.

    Source

    Clinics in sports medicine 36:3 2017 Jul pg 525-548

    MeSH

    Cartilage Diseases
    Cartilage, Articular
    Chondrocytes
    Humans
    Knee Injuries
    Transplantation, Autologous

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28577711

    Citation

    Hinckel, Betina B., and Andreas H. Gomoll. "Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation." Clinics in Sports Medicine, vol. 36, no. 3, 2017, pp. 525-548.
    Hinckel BB, Gomoll AH. Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clin Sports Med. 2017;36(3):525-548.
    Hinckel, B. B., & Gomoll, A. H. (2017). Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clinics in Sports Medicine, 36(3), pp. 525-548. doi:10.1016/j.csm.2017.02.008.
    Hinckel BB, Gomoll AH. Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clin Sports Med. 2017;36(3):525-548. PubMed PMID: 28577711.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. AU - Hinckel,Betina B, AU - Gomoll,Andreas H, PY - 2017/6/5/entrez PY - 2017/6/5/pubmed PY - 2017/10/11/medline KW - Articular/*surgery KW - Autologous KW - Autologous chondrocyte implantation KW - Cartilage KW - Cartilage repair KW - Chondrocytes/*transplantation KW - Knee KW - Transplantation SP - 525 EP - 548 JF - Clinics in sports medicine JO - Clin Sports Med VL - 36 IS - 3 N2 - Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocyte culture, and chondrocyte implantation. The techniques and their outcomes are discussed in this article. SN - 1556-228X UR - https://www.unboundmedicine.com/medline/citation/28577711/Autologous_Chondrocytes_and_Next_Generation_Matrix_Based_Autologous_Chondrocyte_Implantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5919(17)30010-8 DB - PRIME DP - Unbound Medicine ER -