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Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation.
Clin Sports Med 2017; 36(3):525-548CS

Abstract

Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocyte culture, and chondrocyte implantation. The techniques and their outcomes are discussed in this article.

Authors+Show Affiliations

Missouri Orthopaedic Institute, University of Missouri, Virginia Avenue, Columbia, MO, USA.Cartilage Repair Center, Brigham and Women's Hospital, Chestnut Hill, MA, USA. Electronic address: AGOMOLL@BWH.HARVARD.EDU.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28577711

Citation

Hinckel, Betina B., and Andreas H. Gomoll. "Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation." Clinics in Sports Medicine, vol. 36, no. 3, 2017, pp. 525-548.
Hinckel BB, Gomoll AH. Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clin Sports Med. 2017;36(3):525-548.
Hinckel, B. B., & Gomoll, A. H. (2017). Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clinics in Sports Medicine, 36(3), pp. 525-548. doi:10.1016/j.csm.2017.02.008.
Hinckel BB, Gomoll AH. Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. Clin Sports Med. 2017;36(3):525-548. PubMed PMID: 28577711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation. AU - Hinckel,Betina B, AU - Gomoll,Andreas H, PY - 2017/6/5/entrez PY - 2017/6/5/pubmed PY - 2017/10/11/medline KW - Articular/*surgery KW - Autologous KW - Autologous chondrocyte implantation KW - Cartilage KW - Cartilage repair KW - Chondrocytes/*transplantation KW - Knee KW - Transplantation SP - 525 EP - 548 JF - Clinics in sports medicine JO - Clin Sports Med VL - 36 IS - 3 N2 - Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocyte culture, and chondrocyte implantation. The techniques and their outcomes are discussed in this article. SN - 1556-228X UR - https://www.unboundmedicine.com/medline/citation/28577711/Autologous_Chondrocytes_and_Next_Generation_Matrix_Based_Autologous_Chondrocyte_Implantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5919(17)30010-8 DB - PRIME DP - Unbound Medicine ER -