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The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction.
Behav Brain Res. 2017 08 14; 332:200-203.BB

Abstract

Extinction of conditioned fear has been suggested to be a new form of learning instead of erasure of what was originally learned, and the process is NMDA (N-methyl d-aspartate) receptor (NMDAR) dependent. Most of studies have so far revealed the important roles of NMDARs in the amygdala and medial prefrontal cortex (mPFC) in cued fear extinction. Although the ventral hippocampus has intimately reciprocal connections with the amygdala and mPFC, the role of its NMDARs in cued fear extinction remains unclear. The present experiment explored the issue by bilateral pre-extinction microinjection of the noncompetitive NMDAR antagonist MK-801 into the ventral hippocampus. Four groups of rats were given habituation, tone cued fear conditioning, fear extinction training and extinction test. Prior to extinction training, rats received bilateral infusions of either MK-801 (1.5, 3, or 6μg/0.5μl) or saline. Our results showed that MK-801 reduced freezing on the first trial of extinction training with no impact on within-session acquisition of extinction, and that the lower doses of MK-801 resulted in increased freezing on the extinction retrieval test. These findings suggest that ventral hippocampal NMDARs are necessary for the consolidation of tone cued fear extinction.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhang B
Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address: bozhangpp@foxmail.com.
Li CY
Yunnan Key Laboratory of Primate Biomedicine Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
Wang XS
Key Laboratory of Animal Resistance Biology of Shandong Province, Department of Anatomy, Physiology and Development, College of Life Science, Shandong Normal University, Jinan 250000, China. Electronic address: wangxiusong@gmail.com.

MeSH

AnimalsAuditory PerceptionCuesDizocilpine MaleateDose-Response Relationship, DrugExcitatory Amino Acid AntagonistsExtinction, PsychologicalFearFreezing Reaction, CatalepticHippocampusMaleMicroinjectionsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28578988

Citation

Zhang, Bo, et al. "The Effect of Hippocampal NMDA Receptor Blockade By MK-801 On Cued Fear Extinction." Behavioural Brain Research, vol. 332, 2017, pp. 200-203.
Zhang B, Li CY, Wang XS. The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction. Behav Brain Res. 2017;332:200-203.
Zhang, B., Li, C. Y., & Wang, X. S. (2017). The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction. Behavioural Brain Research, 332, 200-203. https://doi.org/10.1016/j.bbr.2017.05.067
Zhang B, Li CY, Wang XS. The Effect of Hippocampal NMDA Receptor Blockade By MK-801 On Cued Fear Extinction. Behav Brain Res. 2017 08 14;332:200-203. PubMed PMID: 28578988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction. AU - Zhang,Bo, AU - Li,Chuan-Yu, AU - Wang,Xiu-Song, Y1 - 2017/06/01/ PY - 2016/10/28/received PY - 2017/05/24/revised PY - 2017/05/30/accepted PY - 2017/6/6/pubmed PY - 2017/12/13/medline PY - 2017/6/6/entrez KW - Consolidation KW - Cued fear extinction KW - NMDA receptors KW - Ventral hippocampus SP - 200 EP - 203 JF - Behavioural brain research JO - Behav Brain Res VL - 332 N2 - Extinction of conditioned fear has been suggested to be a new form of learning instead of erasure of what was originally learned, and the process is NMDA (N-methyl d-aspartate) receptor (NMDAR) dependent. Most of studies have so far revealed the important roles of NMDARs in the amygdala and medial prefrontal cortex (mPFC) in cued fear extinction. Although the ventral hippocampus has intimately reciprocal connections with the amygdala and mPFC, the role of its NMDARs in cued fear extinction remains unclear. The present experiment explored the issue by bilateral pre-extinction microinjection of the noncompetitive NMDAR antagonist MK-801 into the ventral hippocampus. Four groups of rats were given habituation, tone cued fear conditioning, fear extinction training and extinction test. Prior to extinction training, rats received bilateral infusions of either MK-801 (1.5, 3, or 6μg/0.5μl) or saline. Our results showed that MK-801 reduced freezing on the first trial of extinction training with no impact on within-session acquisition of extinction, and that the lower doses of MK-801 resulted in increased freezing on the extinction retrieval test. These findings suggest that ventral hippocampal NMDARs are necessary for the consolidation of tone cued fear extinction. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/28578988/The_effect_of_hippocampal_NMDA_receptor_blockade_by_MK_801_on_cued_fear_extinction_ DB - PRIME DP - Unbound Medicine ER -