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Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome.

Abstract

76 selected overactive children were treated with an oligoantigenic diet, 62 improved, and a normal range of behaviour was achieved in 21 of these. Other symptoms, such as headaches, abdominal pain, and fits, also often improved. 28 of the children who improved completed a double-blind, crossover, placebo-controlled trial in which foods thought to provoke symptoms were reintroduced. Symptoms returned or were exacerbated much more often when patients were on active material than on placebo. 48 foods were incriminated. Artificial colorants and preservatives were the commonest provoking substances, but no child was sensitive to these alone.

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  • Authors

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    Source

    Lancet (London, England) 1:8428 1985 Mar 09 pg 540-5

    MeSH

    Adolescent
    Attention Deficit Disorder with Hyperactivity
    Child
    Child Behavior
    Child, Preschool
    Clinical Trials as Topic
    Double-Blind Method
    Female
    Food Coloring Agents
    Food Hypersensitivity
    Food Preservatives
    Humans
    Male
    Psychological Tests

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    2857900

    Citation

    Egger, J, et al. "Controlled Trial of Oligoantigenic Treatment in the Hyperkinetic Syndrome." Lancet (London, England), vol. 1, no. 8428, 1985, pp. 540-5.
    Egger J, Carter CM, Graham PJ, et al. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet. 1985;1(8428):540-5.
    Egger, J., Carter, C. M., Graham, P. J., Gumley, D., & Soothill, J. F. (1985). Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet (London, England), 1(8428), pp. 540-5.
    Egger J, et al. Controlled Trial of Oligoantigenic Treatment in the Hyperkinetic Syndrome. Lancet. 1985 Mar 9;1(8428):540-5. PubMed PMID: 2857900.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. AU - Egger,J, AU - Carter,C M, AU - Graham,P J, AU - Gumley,D, AU - Soothill,J F, PY - 1985/3/9/pubmed PY - 1985/3/9/medline PY - 1985/3/9/entrez SP - 540 EP - 5 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8428 N2 - 76 selected overactive children were treated with an oligoantigenic diet, 62 improved, and a normal range of behaviour was achieved in 21 of these. Other symptoms, such as headaches, abdominal pain, and fits, also often improved. 28 of the children who improved completed a double-blind, crossover, placebo-controlled trial in which foods thought to provoke symptoms were reintroduced. Symptoms returned or were exacerbated much more often when patients were on active material than on placebo. 48 foods were incriminated. Artificial colorants and preservatives were the commonest provoking substances, but no child was sensitive to these alone. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2857900/Controlled_trial_of_oligoantigenic_treatment_in_the_hyperkinetic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(85)91206-1 DB - PRIME DP - Unbound Medicine ER -