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The application of optical coherence tomography angiography in retinal diseases.
Surv Ophthalmol. 2017 Nov - Dec; 62(6):838-866.SO

Abstract

Optical coherence tomography angiography (OCTA) is a new, noninvasive imaging technique that generates real-time volumetric data on chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established enface chorioretinal segmentation, and efficient algorithms, OCTA generates images that resemble an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels. OCTA has shown promise in the evaluation of common ophthalmologic diseases such as diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusions. It quantifies vascular compromise reflecting the severity of diabetic retinopathy. OCTA detects the presence of choroidal neovascularization in exudative age-related macular degeneration and maps loss of choriocapillaris in nonexudative age-related macular degeneration. We describe principles of OCTA and findings in common and some uncommon retinal pathologies. Finally, we summarize its potential future applications. Its current limitations include a relatively small field of view, inability to show leakage, and a tendency for image artifacts. Further larger studies will define OCTAs utility in clinical settings and establish if the technology may offer its utility in decreasing morbidity through early detection and guide therapeutic interventions in retinal diseases.

Authors+Show Affiliations

Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, Florida, USA.Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, Florida, USA.Department of Ophthalmology, University of Florida College of Medicine, Jacksonville, Florida, USA. Electronic address: kvchalam@aol.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28579550

Citation

Sambhav, Kumar, et al. "The Application of Optical Coherence Tomography Angiography in Retinal Diseases." Survey of Ophthalmology, vol. 62, no. 6, 2017, pp. 838-866.
Sambhav K, Grover S, Chalam KV. The application of optical coherence tomography angiography in retinal diseases. Surv Ophthalmol. 2017;62(6):838-866.
Sambhav, K., Grover, S., & Chalam, K. V. (2017). The application of optical coherence tomography angiography in retinal diseases. Survey of Ophthalmology, 62(6), 838-866. https://doi.org/10.1016/j.survophthal.2017.05.006
Sambhav K, Grover S, Chalam KV. The Application of Optical Coherence Tomography Angiography in Retinal Diseases. Surv Ophthalmol. 2017 Nov - Dec;62(6):838-866. PubMed PMID: 28579550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The application of optical coherence tomography angiography in retinal diseases. AU - Sambhav,Kumar, AU - Grover,Sandeep, AU - Chalam,Kakarla V, Y1 - 2017/06/01/ PY - 2016/06/30/received PY - 2017/05/18/revised PY - 2017/05/19/accepted PY - 2017/6/6/pubmed PY - 2017/12/6/medline PY - 2017/6/6/entrez KW - OCT angiography ratio analysis (OCTARA) KW - OCT-based optical microangiography (OMAG) KW - age-related macular degeneration KW - choroidal neovascularization KW - diabetic retinopathy KW - motion contrast KW - optical coherence tomography angiography (OCTA) KW - split-spectrum amplitude decorrelation angiography (SSADA) SP - 838 EP - 866 JF - Survey of ophthalmology JO - Surv Ophthalmol VL - 62 IS - 6 N2 - Optical coherence tomography angiography (OCTA) is a new, noninvasive imaging technique that generates real-time volumetric data on chorioretinal vasculature and its flow pattern. With the advent of high-speed optical coherence tomography, established enface chorioretinal segmentation, and efficient algorithms, OCTA generates images that resemble an angiogram. The principle of OCTA involves determining the change in backscattering between consecutive B-scans and then attributing the differences to the flow of erythrocytes through retinal blood vessels. OCTA has shown promise in the evaluation of common ophthalmologic diseases such as diabetic retinopathy, age-related macular degeneration, and retinal vascular occlusions. It quantifies vascular compromise reflecting the severity of diabetic retinopathy. OCTA detects the presence of choroidal neovascularization in exudative age-related macular degeneration and maps loss of choriocapillaris in nonexudative age-related macular degeneration. We describe principles of OCTA and findings in common and some uncommon retinal pathologies. Finally, we summarize its potential future applications. Its current limitations include a relatively small field of view, inability to show leakage, and a tendency for image artifacts. Further larger studies will define OCTAs utility in clinical settings and establish if the technology may offer its utility in decreasing morbidity through early detection and guide therapeutic interventions in retinal diseases. SN - 1879-3304 UR - https://www.unboundmedicine.com/medline/citation/28579550/The_application_of_optical_coherence_tomography_angiography_in_retinal_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6257(16)30110-2 DB - PRIME DP - Unbound Medicine ER -