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Age-related changes of white matter association tracts in normal children throughout adulthood: a diffusion tensor tractography study.
Neuroradiology. 2017 Jul; 59(7):715-724.N

Abstract

PURPOSE

The aim of this study is to study the age, gender and lateral asymmetry-related white matter changes of long association tracts throughout late childhood and adolescence into adulthood using diffusion tensor tractography (DTT).

METHODS

DTT was performed in 44 healthy subjects aged 7-45 years. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), Trace, density and volume were calculated for long association tracts, namely the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), uncinate fasciculus, superior longitudinal fasciculus (SLF) and its arcuate fibres. FA and diffusivity indices were correlated as function of age using Pearson correlation test. Comparison between males and females, and comparison between both hemispheres among all participants were also performed. A p value less than .01 was considered significant.

RESULTS

The majority of the examined tracts (SLF and IFOF of both hemispheres, and the arcuate fasciculus, uncinate fasciculus, and ILF of the left hemisphere) followed a common pattern of metric changes with age. This pattern was characterized by significant FA increase accompanied by reduction in RD, Trace without significant AD changes. The right arcuate fasciculus showed similar pattern but without significant FA changes. The right uncinate and right ILF fasciculus demonstrated significant reduction in RD, Trace and AD, with and without significant FA increase, respectively. Left hemispheric dominance regarding the FA and diffusivity indices was demonstrated in uncinate fasciculus with no significant gender-related differences.

CONCLUSION

Significant microstructural tract-specific maturation processes continue throughout late childhood into adulthood. These processes may represent stages in a cascade of age-related maturation in white matter microstructure.

Authors+Show Affiliations

Radiodiagnosis department, Faculty of medicine, Ain-Shams University, 9 Lotfi Elsayed St. Ain-Shams University Staff Buildings, Cairo, 11657, Egypt. Shaimaa96@hotmail.com.National Research Centre, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28580531

Citation

Mohammad, Shaimaa Abdelsattar, and Neveen Hassan Nashaat. "Age-related Changes of White Matter Association Tracts in Normal Children Throughout Adulthood: a Diffusion Tensor Tractography Study." Neuroradiology, vol. 59, no. 7, 2017, pp. 715-724.
Mohammad SA, Nashaat NH. Age-related changes of white matter association tracts in normal children throughout adulthood: a diffusion tensor tractography study. Neuroradiology. 2017;59(7):715-724.
Mohammad, S. A., & Nashaat, N. H. (2017). Age-related changes of white matter association tracts in normal children throughout adulthood: a diffusion tensor tractography study. Neuroradiology, 59(7), 715-724. https://doi.org/10.1007/s00234-017-1858-3
Mohammad SA, Nashaat NH. Age-related Changes of White Matter Association Tracts in Normal Children Throughout Adulthood: a Diffusion Tensor Tractography Study. Neuroradiology. 2017;59(7):715-724. PubMed PMID: 28580531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes of white matter association tracts in normal children throughout adulthood: a diffusion tensor tractography study. AU - Mohammad,Shaimaa Abdelsattar, AU - Nashaat,Neveen Hassan, Y1 - 2017/06/03/ PY - 2017/02/21/received PY - 2017/05/22/accepted PY - 2017/6/6/pubmed PY - 2017/11/29/medline PY - 2017/6/6/entrez KW - Axial diffusivity KW - Diffusion tensor imaging KW - Fractional anisotropy KW - Maturation patterns KW - Radial diffusivity SP - 715 EP - 724 JF - Neuroradiology JO - Neuroradiology VL - 59 IS - 7 N2 - PURPOSE: The aim of this study is to study the age, gender and lateral asymmetry-related white matter changes of long association tracts throughout late childhood and adolescence into adulthood using diffusion tensor tractography (DTT). METHODS: DTT was performed in 44 healthy subjects aged 7-45 years. Fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), Trace, density and volume were calculated for long association tracts, namely the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), uncinate fasciculus, superior longitudinal fasciculus (SLF) and its arcuate fibres. FA and diffusivity indices were correlated as function of age using Pearson correlation test. Comparison between males and females, and comparison between both hemispheres among all participants were also performed. A p value less than .01 was considered significant. RESULTS: The majority of the examined tracts (SLF and IFOF of both hemispheres, and the arcuate fasciculus, uncinate fasciculus, and ILF of the left hemisphere) followed a common pattern of metric changes with age. This pattern was characterized by significant FA increase accompanied by reduction in RD, Trace without significant AD changes. The right arcuate fasciculus showed similar pattern but without significant FA changes. The right uncinate and right ILF fasciculus demonstrated significant reduction in RD, Trace and AD, with and without significant FA increase, respectively. Left hemispheric dominance regarding the FA and diffusivity indices was demonstrated in uncinate fasciculus with no significant gender-related differences. CONCLUSION: Significant microstructural tract-specific maturation processes continue throughout late childhood into adulthood. These processes may represent stages in a cascade of age-related maturation in white matter microstructure. SN - 1432-1920 UR - https://www.unboundmedicine.com/medline/citation/28580531/Age_related_changes_of_white_matter_association_tracts_in_normal_children_throughout_adulthood:_a_diffusion_tensor_tractography_study_ L2 - https://dx.doi.org/10.1007/s00234-017-1858-3 DB - PRIME DP - Unbound Medicine ER -