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Clinical grading of Reinke's edema.
Laryngoscope. 2017 10; 127(10):2310-2313.L

Abstract

OBJECTIVE

Reinke's edema (RE) is a pathologically benign structural change of the vocal folds with a wide spectrum of clinical severity. We aim to propose and validate a clinical grading system based on size of the lesion to facilitate effective universal communication of disease severity.

STUDY DESIGN

Retrospective review.

METHODS

Patients diagnosed with RE exclusive of other glottic pathology between December 2010 and December 2014 were included. Sixty laryngoscopy photographs were extracted from recorded archived laryngeal videostroboscopy exams, blinded and graded by four laryngologists with experience diagnosing RE.

RESULTS

A high degree of agreement among all four raters was demonstrated by high interclass correlation coefficients with a 95% confidence interval. Similarly, high intra-rater reliability was seen across all raters. Forty-nine (33%) lesions were grade 1. Thirty-five lesions (29.17%) were grade 2; 18 (15%) lesions were grade 3; and nine (7.5%) lesions were grade 4. Contralateral vocal fold was not graded in cases of grade 4.

CONCLUSION

This clinical grading for RE is a reliable tool for conveying severity of disease. High inter- and intra-rater reliability strongly suggest that RE similarly can be graded by different raters, and that a single rater is expected to grade RE similarly at different times.

LEVEL OF EVIDENCE

4. Laryngoscope, 127:2310-2313, 2017.

Authors+Show Affiliations

Montefiore Medical Center, Department of Otorhinolaryngology - Head and Neck Surgery.Cleveland Clinic Foundation, Department of Otolaryngology, Cleveland, Ohio, U.S.A.Albert Einstein College of Medicine, Bronx.Mount Sinai Medical Center, Department of Otolaryngology, New York, New York.Cleveland Clinic Foundation, Department of Otolaryngology, Cleveland, Ohio, U.S.A.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28581063

Citation

Tan, Melin, et al. "Clinical Grading of Reinke's Edema." The Laryngoscope, vol. 127, no. 10, 2017, pp. 2310-2313.
Tan M, Bryson PC, Pitts C, et al. Clinical grading of Reinke's edema. Laryngoscope. 2017;127(10):2310-2313.
Tan, M., Bryson, P. C., Pitts, C., Woo, P., & Benninger, M. S. (2017). Clinical grading of Reinke's edema. The Laryngoscope, 127(10), 2310-2313. https://doi.org/10.1002/lary.26647
Tan M, et al. Clinical Grading of Reinke's Edema. Laryngoscope. 2017;127(10):2310-2313. PubMed PMID: 28581063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical grading of Reinke's edema. AU - Tan,Melin, AU - Bryson,Paul C, AU - Pitts,Casey, AU - Woo,Peak, AU - Benninger,Michael S, Y1 - 2017/06/05/ PY - 2016/11/17/received PY - 2017/03/15/revised PY - 2017/03/20/accepted PY - 2017/6/6/pubmed PY - 2017/9/30/medline PY - 2017/6/6/entrez KW - Reinke's edema KW - grading KW - polypoid corditis KW - upper airway obstruction KW - vocal fold polyps SP - 2310 EP - 2313 JF - The Laryngoscope JO - Laryngoscope VL - 127 IS - 10 N2 - OBJECTIVE: Reinke's edema (RE) is a pathologically benign structural change of the vocal folds with a wide spectrum of clinical severity. We aim to propose and validate a clinical grading system based on size of the lesion to facilitate effective universal communication of disease severity. STUDY DESIGN: Retrospective review. METHODS: Patients diagnosed with RE exclusive of other glottic pathology between December 2010 and December 2014 were included. Sixty laryngoscopy photographs were extracted from recorded archived laryngeal videostroboscopy exams, blinded and graded by four laryngologists with experience diagnosing RE. RESULTS: A high degree of agreement among all four raters was demonstrated by high interclass correlation coefficients with a 95% confidence interval. Similarly, high intra-rater reliability was seen across all raters. Forty-nine (33%) lesions were grade 1. Thirty-five lesions (29.17%) were grade 2; 18 (15%) lesions were grade 3; and nine (7.5%) lesions were grade 4. Contralateral vocal fold was not graded in cases of grade 4. CONCLUSION: This clinical grading for RE is a reliable tool for conveying severity of disease. High inter- and intra-rater reliability strongly suggest that RE similarly can be graded by different raters, and that a single rater is expected to grade RE similarly at different times. LEVEL OF EVIDENCE: 4. Laryngoscope, 127:2310-2313, 2017. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/28581063/Clinical_grading_of_Reinke's_edema L2 - https://doi.org/10.1002/lary.26647 DB - PRIME DP - Unbound Medicine ER -