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Bone mineralization and densitometric evaluation of vertebral fractures in women 6-21 years after the onset of anorexia nervosa symptoms.
Psychiatr Pol 2017; 51(2):231-246PP

Abstract

OBJECTIVES

We attempted to assess bone mineralization and the frequency of fractures occurrence in women with a history of treatment of anorexia nervosa (AN) in adolescence.

METHODS

47 women (age 20-36.8 years) were re-examined 6.33-21,2 years after the onset of AN symptoms. Bone mineral density (BMD) of total body, lumbar spine, femoral neck, total hip (DXA) and densitometric Vertebral Fracture Assessment (VFA) were performed on 46 of women and BAP, P1NP, CTX, estradiol, testosterone, cortisol, IGF-1, leptin, DHEA-S on 45 of women entered for the current study. Current BMD results were compared with available baseline results from the time of hospitalization.

RESULTS

Currently BMD Z-score <-1 examined at any location occurred in 28 from 46 women (including Z-score <-2 in 5 women). In 11 from 12 women with reduced BMD at the time of hospitalization current total body BMD was within the normal range. Lumbar spine BMD was normalized or improved respectively in 5 and 6 from 15 women. Currently increased levels/activity of bone formation markers: P1NP in 27 (60%) and BAP in 28 women (62.2%) were observed. In 7 women (15.6%) increased values of bone formation markers with increased marker of bone resorption (CTX) occurred. Osteoporotic fractures and fractures in the spine in VFA were not observed during the observation period.

CONCLUSIONS

Despite early treatment of adolescent-onset AN and good outcomes of the treatment, decreased BMD was currently present in 60.9% of women. During follow-up normalization or significant improvement in BMD results (total body, lumbar spine) were observed in majority of cases.

Authors+Show Affiliations

Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych, Warszawski Uniwersytet Medyczny.Katedra i Klinika Chorób Wewnętrznych i Endokrynologii, Warszawski Uniwersytet Medyczny.Katedra i Klinika Chorób Wewnętrznych i Endokrynologii, Warszawski Uniwersytet Medyczny.Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.II Zakład Radiologii Klinicznej, Warszawski Uniwersytet Medyczny.Zakład Radiologii Pediatrycznej, Warszawski Uniwersytet Medyczny.Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.Klinika Psychiatrii Wieku Rozwojowego, Warszawski Uniwersytet Medyczny.

Pub Type(s)

Journal Article

Language

eng pol

PubMed ID

28581534

Citation

Jagielska, Gabriela, et al. "Bone Mineralization and Densitometric Evaluation of Vertebral Fractures in Women 6-21 Years After the Onset of Anorexia Nervosa Symptoms." Psychiatria Polska, vol. 51, no. 2, 2017, pp. 231-246.
Jagielska G, Przedlacki J, Bartoszewicz Z, et al. Bone mineralization and densitometric evaluation of vertebral fractures in women 6-21 years after the onset of anorexia nervosa symptoms. Psychiatr Pol. 2017;51(2):231-246.
Jagielska, G., Przedlacki, J., Bartoszewicz, Z., Kondracka, A., Butwicka, A., Racicka, E., ... Szymańska, U. (2017). Bone mineralization and densitometric evaluation of vertebral fractures in women 6-21 years after the onset of anorexia nervosa symptoms. Psychiatria Polska, 51(2), pp. 231-246. doi:10.12740/PP/63149.
Jagielska G, et al. Bone Mineralization and Densitometric Evaluation of Vertebral Fractures in Women 6-21 Years After the Onset of Anorexia Nervosa Symptoms. Psychiatr Pol. 2017 Apr 30;51(2):231-246. PubMed PMID: 28581534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineralization and densitometric evaluation of vertebral fractures in women 6-21 years after the onset of anorexia nervosa symptoms. AU - Jagielska,Gabriela, AU - Przedlacki,Jerzy, AU - Bartoszewicz,Zbigniew, AU - Kondracka,Agnieszka, AU - Butwicka,Agnieszka, AU - Racicka,Ewa, AU - Rowiński,Olgierd, AU - Brzewski,Rafał, AU - Wolańczyk,Tomasz, AU - Tomaszewicz-Libudzic,Celina, AU - Szymańska,Urszula, Y1 - 2017/04/30/ PY - 2017/6/6/entrez PY - 2017/6/6/pubmed PY - 2017/10/24/medline KW - anorexia nervosa KW - densitometric vertebral fracture assessment KW - osteoporosis SP - 231 EP - 246 JF - Psychiatria polska JO - Psychiatr. Pol. VL - 51 IS - 2 N2 - OBJECTIVES: We attempted to assess bone mineralization and the frequency of fractures occurrence in women with a history of treatment of anorexia nervosa (AN) in adolescence. METHODS: 47 women (age 20-36.8 years) were re-examined 6.33-21,2 years after the onset of AN symptoms. Bone mineral density (BMD) of total body, lumbar spine, femoral neck, total hip (DXA) and densitometric Vertebral Fracture Assessment (VFA) were performed on 46 of women and BAP, P1NP, CTX, estradiol, testosterone, cortisol, IGF-1, leptin, DHEA-S on 45 of women entered for the current study. Current BMD results were compared with available baseline results from the time of hospitalization. RESULTS: Currently BMD Z-score <-1 examined at any location occurred in 28 from 46 women (including Z-score <-2 in 5 women). In 11 from 12 women with reduced BMD at the time of hospitalization current total body BMD was within the normal range. Lumbar spine BMD was normalized or improved respectively in 5 and 6 from 15 women. Currently increased levels/activity of bone formation markers: P1NP in 27 (60%) and BAP in 28 women (62.2%) were observed. In 7 women (15.6%) increased values of bone formation markers with increased marker of bone resorption (CTX) occurred. Osteoporotic fractures and fractures in the spine in VFA were not observed during the observation period. CONCLUSIONS: Despite early treatment of adolescent-onset AN and good outcomes of the treatment, decreased BMD was currently present in 60.9% of women. During follow-up normalization or significant improvement in BMD results (total body, lumbar spine) were observed in majority of cases. SN - 2391-5854 UR - https://www.unboundmedicine.com/medline/citation/28581534/Bone_mineralization_and_densitometric_evaluation_of_vertebral_fractures_in_women_6_21_years_after_the_onset_of_anorexia_nervosa_symptoms_ L2 - https://doi.org/10.12740/PP/63149 DB - PRIME DP - Unbound Medicine ER -