Tags

Type your tag names separated by a space and hit enter

Tardive dyskinesia in the aged. Duration of treatment relationships.
Arch Gen Psychiatry. 1985 Mar; 42(3):278-84.AG

Abstract

Although tardive dyskinesia (TD) is recognized to result from neuroleptic drug exposure, data conflict about the importance of the quantity of that exposure in producing TD. The relationship between duration of neuroleptic treatment (one to 301 months) and TD was studied in 57 elderly psychiatric inpatients. Examinations for TD and parkinsonism were quantified on the Abnormal Involuntary Movement Scale (AIMS) and on a parkinsonism severity scale. Prevalence of presumed TD was 49% and of parkinsonism 51%. Prevalence of TD increased with longer treatment, but parkinsonism was independent of treatment duration. Linear multiple regression analysis showed that the AIMS score was correlated positively with treatment duration and negatively with parkinsonism. Logistic multiple regression analysis verified these relationships and was more successful at predicting TD. The length of neuroleptic treatment necessary to produce TD was calculated from the logistic model at 10.8 months (95% confidence interval, zero to 25.6 months). These analyses showed the greatest rise in risk of TD occurred within the first two years of drug therapy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2858189

Citation

Toenniessen, L M., et al. "Tardive Dyskinesia in the Aged. Duration of Treatment Relationships." Archives of General Psychiatry, vol. 42, no. 3, 1985, pp. 278-84.
Toenniessen LM, Casey DE, McFarland BH. Tardive dyskinesia in the aged. Duration of treatment relationships. Arch Gen Psychiatry. 1985;42(3):278-84.
Toenniessen, L. M., Casey, D. E., & McFarland, B. H. (1985). Tardive dyskinesia in the aged. Duration of treatment relationships. Archives of General Psychiatry, 42(3), 278-84.
Toenniessen LM, Casey DE, McFarland BH. Tardive Dyskinesia in the Aged. Duration of Treatment Relationships. Arch Gen Psychiatry. 1985;42(3):278-84. PubMed PMID: 2858189.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tardive dyskinesia in the aged. Duration of treatment relationships. AU - Toenniessen,L M, AU - Casey,D E, AU - McFarland,B H, PY - 1985/3/1/pubmed PY - 1985/3/1/medline PY - 1985/3/1/entrez SP - 278 EP - 84 JF - Archives of general psychiatry JO - Arch Gen Psychiatry VL - 42 IS - 3 N2 - Although tardive dyskinesia (TD) is recognized to result from neuroleptic drug exposure, data conflict about the importance of the quantity of that exposure in producing TD. The relationship between duration of neuroleptic treatment (one to 301 months) and TD was studied in 57 elderly psychiatric inpatients. Examinations for TD and parkinsonism were quantified on the Abnormal Involuntary Movement Scale (AIMS) and on a parkinsonism severity scale. Prevalence of presumed TD was 49% and of parkinsonism 51%. Prevalence of TD increased with longer treatment, but parkinsonism was independent of treatment duration. Linear multiple regression analysis showed that the AIMS score was correlated positively with treatment duration and negatively with parkinsonism. Logistic multiple regression analysis verified these relationships and was more successful at predicting TD. The length of neuroleptic treatment necessary to produce TD was calculated from the logistic model at 10.8 months (95% confidence interval, zero to 25.6 months). These analyses showed the greatest rise in risk of TD occurred within the first two years of drug therapy. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/2858189/Tardive_dyskinesia_in_the_aged__Duration_of_treatment_relationships_ L2 - https://jamanetwork.com/journals/jamapsychiatry/fullarticle/vol/42/pg/278 DB - PRIME DP - Unbound Medicine ER -