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Prenylated flavonoids from Commiphora opobalsamum stem bark.
Phytochemistry. 2017 Sep; 141:80-85.P

Abstract

A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively.

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Authors+Show Affiliations

El-Gamal AA
Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmacognosy, Mansoura University, Faculty of Pharmacy, 35516, El-Mansoura, Egypt. Electronic address: aelgamal00@yahoo.com.
Al-Massarani SM
Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Abdel-Mageed WM
Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt. Electronic address: waelcognosy@yahoo.com.
El-Shaibany A
Department of Pharmacognosy, College of Pharmacy, P.O. Box 33039, Sana'a University, Sana'a, Yemen.
Al-Mahbashi HM
Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Sana'a University, Sana'a, Yemen.
Basudan OA
Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Badria FA
Department of Pharmacognosy, Mansoura University, Faculty of Pharmacy, 35516, El-Mansoura, Egypt.
Al-Said MS
Department of Pharmacognosy, King Saud University, College of Pharmacy, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Abdel-Kader MS
Department of Pharmacognosy, Sattam Bin Abdulaziz University, College of Pharmacy, 11942, Al-kharj, Saudi Arabia.

MeSH

Antineoplastic Agents, PhytogenicCommiphoraDrug Screening Assays, AntitumorFlavonoidsHep G2 CellsHumansMCF-7 CellsMolecular StructurePlant BarkPrenylation

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28582635

Citation

El-Gamal, Ali A., et al. "Prenylated Flavonoids From Commiphora Opobalsamum Stem Bark." Phytochemistry, vol. 141, 2017, pp. 80-85.
El-Gamal AA, Al-Massarani SM, Abdel-Mageed WM, et al. Prenylated flavonoids from Commiphora opobalsamum stem bark. Phytochemistry. 2017;141:80-85.
El-Gamal, A. A., Al-Massarani, S. M., Abdel-Mageed, W. M., El-Shaibany, A., Al-Mahbashi, H. M., Basudan, O. A., Badria, F. A., Al-Said, M. S., & Abdel-Kader, M. S. (2017). Prenylated flavonoids from Commiphora opobalsamum stem bark. Phytochemistry, 141, 80-85. https://doi.org/10.1016/j.phytochem.2017.05.014
El-Gamal AA, et al. Prenylated Flavonoids From Commiphora Opobalsamum Stem Bark. Phytochemistry. 2017;141:80-85. PubMed PMID: 28582635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenylated flavonoids from Commiphora opobalsamum stem bark. AU - El-Gamal,Ali A, AU - Al-Massarani,Shaza M, AU - Abdel-Mageed,Wael M, AU - El-Shaibany,Amina, AU - Al-Mahbashi,Hassan M, AU - Basudan,Omer A, AU - Badria,Farid A, AU - Al-Said,Mansour S, AU - Abdel-Kader,Maged S, Y1 - 2017/06/03/ PY - 2017/01/12/received PY - 2017/05/16/revised PY - 2017/05/27/accepted PY - 2017/6/6/pubmed PY - 2017/7/22/medline PY - 2017/6/6/entrez KW - Burseraceae KW - Commiphora opobalsamum KW - Cytotoxic activity KW - Flavonoids KW - Prenylated flavonoids SP - 80 EP - 85 JF - Phytochemistry JO - Phytochemistry VL - 141 N2 - A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7). Comophoroside A revealed to retain the strongest cytotoxic activity against MCF-7 and HepG-2 cell lines with IC50 values of 8 and 12 μg/mL, respectively. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/28582635/Prenylated_flavonoids_from_Commiphora_opobalsamum_stem_bark_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(17)30216-9 DB - PRIME DP - Unbound Medicine ER -