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Serum fatty acid profile in psoriasis and its comorbidity.
Arch Dermatol Res 2017; 309(5):371-380AD

Abstract

Psoriasis is a chronic inflammatory skin disease that is accompanied by metabolic disturbances and cardio-metabolic disorders. Fatty acids (FAs) might be a link between psoriasis and its comorbidity. The aim of the study was to evaluate serum concentrations of FAs and to investigate their association with the disease activity, markers of inflammation and possible involvement in psoriatic comorbidity: obesity, type 2 diabetes and hypertension. We measured 14 total serum fatty acids content and composition by gas-liquid chromatography and flame-ionization detector after direct in situ transesterification in 85 patients with exacerbated plaque psoriasis and in 32 healthy controls. FAs were grouped according to their biologic properties to saturated FA (SFA), unsaturated FA (UFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA) and n-6 PUFA. Generally, patients characteristic included: Psoriasis Area and Severity Index (PASI), Body Mass Index, inflammatory and biochemical markers, lipid profile and presence of psoriatic comorbidity. We have observed highly abnormal FAs pattern in psoriatic patients both with and without obesity compared to the control group. We have demonstrated association of PASI with low levels of circulating DHA, n-3 PUFA (p = 0.044 and p = 0.048, respectively) and high percent of MUFA (p = 0.024) in the non-obese psoriatic group. The SFA/UFA ratio increased with the duration of the disease (p = 0.03) in all psoriatic patients. These findings indicate abnormal FAs profile in psoriasis which may reflect metabolic disturbances and might play a role in the psoriatic comorbidity.

Authors+Show Affiliations

Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia str. 14, 15-540, Białystok, Poland. hanna.mysliwiec@gmail.com.Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia str. 14, 15-540, Białystok, Poland.Department of Physiology, Medical University of Bialystok, Białystok, Poland.1st Department of General and Endocrinological Surgery, Medical University of Bialystok, Białystok, Poland.Department of Statistics and Medical Informatics, Medical University of Bialystok, Białystok, Poland.Department of Physiology, Medical University of Bialystok, Białystok, Poland.Department of Dermatology and Venereology, Medical University of Bialystok, Żurawia str. 14, 15-540, Białystok, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28585093

Citation

Myśliwiec, Hanna, et al. "Serum Fatty Acid Profile in Psoriasis and Its Comorbidity." Archives of Dermatological Research, vol. 309, no. 5, 2017, pp. 371-380.
Myśliwiec H, Baran A, Harasim-Symbor E, et al. Serum fatty acid profile in psoriasis and its comorbidity. Arch Dermatol Res. 2017;309(5):371-380.
Myśliwiec, H., Baran, A., Harasim-Symbor, E., Myśliwiec, P., Milewska, A. J., Chabowski, A., & Flisiak, I. (2017). Serum fatty acid profile in psoriasis and its comorbidity. Archives of Dermatological Research, 309(5), pp. 371-380. doi:10.1007/s00403-017-1748-x.
Myśliwiec H, et al. Serum Fatty Acid Profile in Psoriasis and Its Comorbidity. Arch Dermatol Res. 2017;309(5):371-380. PubMed PMID: 28585093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum fatty acid profile in psoriasis and its comorbidity. AU - Myśliwiec,Hanna, AU - Baran,Anna, AU - Harasim-Symbor,Ewa, AU - Myśliwiec,Piotr, AU - Milewska,Anna Justyna, AU - Chabowski,Adrian, AU - Flisiak,Iwona, Y1 - 2017/06/05/ PY - 2017/01/27/received PY - 2017/05/29/accepted PY - 2017/05/22/revised PY - 2017/6/7/pubmed PY - 2018/4/3/medline PY - 2017/6/7/entrez KW - Fatty acid KW - MUFA KW - Metabolic syndrome KW - PUFA KW - Psoriasis KW - SFA SP - 371 EP - 380 JF - Archives of dermatological research JO - Arch. Dermatol. Res. VL - 309 IS - 5 N2 - Psoriasis is a chronic inflammatory skin disease that is accompanied by metabolic disturbances and cardio-metabolic disorders. Fatty acids (FAs) might be a link between psoriasis and its comorbidity. The aim of the study was to evaluate serum concentrations of FAs and to investigate their association with the disease activity, markers of inflammation and possible involvement in psoriatic comorbidity: obesity, type 2 diabetes and hypertension. We measured 14 total serum fatty acids content and composition by gas-liquid chromatography and flame-ionization detector after direct in situ transesterification in 85 patients with exacerbated plaque psoriasis and in 32 healthy controls. FAs were grouped according to their biologic properties to saturated FA (SFA), unsaturated FA (UFA), monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA) and n-6 PUFA. Generally, patients characteristic included: Psoriasis Area and Severity Index (PASI), Body Mass Index, inflammatory and biochemical markers, lipid profile and presence of psoriatic comorbidity. We have observed highly abnormal FAs pattern in psoriatic patients both with and without obesity compared to the control group. We have demonstrated association of PASI with low levels of circulating DHA, n-3 PUFA (p = 0.044 and p = 0.048, respectively) and high percent of MUFA (p = 0.024) in the non-obese psoriatic group. The SFA/UFA ratio increased with the duration of the disease (p = 0.03) in all psoriatic patients. These findings indicate abnormal FAs profile in psoriasis which may reflect metabolic disturbances and might play a role in the psoriatic comorbidity. SN - 1432-069X UR - https://www.unboundmedicine.com/medline/citation/28585093/Serum_fatty_acid_profile_in_psoriasis_and_its_comorbidity_ L2 - https://link.springer.com/article/10.1007/s00403-017-1748-x DB - PRIME DP - Unbound Medicine ER -